Discover and read the best of Twitter Threads about #sepsis

Most recents (8)

Pediatric Sepsis Research on LMIC countries: Overcoming challenges. Another oustanding conferences by Daniela @danicds72 #PedsICU #Sepsis@ILASepse⁩ ⁦@WFPICCS⁩ ⁦@LA_Rednetwork⁩ ⁦@slepe8
The Agenda #PedsICU
The 80/20 Rule. We know 80% from those places where the 20% happens #PedsICU @WFPICCS @SLACIP17 @slepe8 @LA_Rednetwork @atip_latam
Read 28 tweets
Thrilling to see so much focus on #sepsis endotyping and reducing heterogeneity at #ISICEM19 @ISICEM! For the non-expert, perhaps a brief review is helpful: /1
Lots of prognostic tools for #sepsis exist, and many are well-validated. Although endotypes often show outcomes differences at baseline, they are NOT for outcomes prediction! Purpose-built tools and biomarkers are better for this. /2
Instead, the goal of #sepsis endotyping is PREDICTIVE enrichment, by which we mean, predicting which patients will respond favorably to a given drug (classically an immunotherapy). Since no drug has ever been shown to work in the broad sepsis population, the idea is that /3
Read 10 tweets
#twitterjournalclub
The ANDROMEDA- SHOCK Randomised Clinical Trial
Thoughts by @z_cepillo
jamanetwork.com/journals/jama/…
Multicentre (28) open label RCT to determine if peripheral perfusion targeted resuscitation during early septic shock in adults is more effective than a lactate-targeted resuscitation for reducing mortality.
Inclusion criteria: adult patients with septic shock (infection, lactate >2, vasopressors to maintain MAP >65mmHg after IV fluid of 20ml/kg over 60 mins.
Read 26 tweets
This week's Tweetorial is by @doctorsinfuga & is on the #CENSER study published by @ATSBlueEditor last week showing early noradrenaline is associated with increased shock control by 6 hours:
atsjournals.org/doi/pdf/10.116…
#atsjournals #sepsis #vasopressors
CENSER was a phase II, randomized, double-blind, placebo-controlled clinical single center trial conducted in Bangkok during the October 2013 to March 2017
Adults aged ≥18 years who presented to the emergency room with MAP<65mmHg and suspected infection were eligible for inclusion
Read 18 tweets
🗣️Hilo

Los mejores artículos #PedsICU (UCIP) del 2018 📖
La suma de lo más relevante publicado y un #Tweetorial acompañante

Selección colaborativa con entre @PICJournalWatch & @sgdambrauskas
Publicado en simultáneo Inglés/Español

Favor comparte. ¡Nos vemos en 2019!
1/
Estudio PARIS en @nejm
Gran estudio que gatilló discusión en el ámbito del #CNAF. Incluso diferentes interpretaciones de resultados de sus coautores

¿Cambió mi práctica? NO
¿Mi investigación? SI

ncbi.nlm.nih.gov/pubmed/29562151

Lean correspondencia:
nejm.org/doi/full/10.10…
2/
ECA en @PedCritCareMed
@pus27 y cols encontraron que #CPAP precoz en niños inmunocomprometidos admitidos en #PedsICU no es mejor (incluso peor) que O2 estándar en 🇬🇧
¿Cambió mi práctica? Quizás
¿Mi investigación? NO

ncbi.nlm.nih.gov/pubmed/30095746
Read 21 tweets
1/ 🗣️
Aquí va un hilo en vivo sobre mis frases preferidas de las III Jornadas Internacionales de @LA_Rednetwork

Here a live-thread about 🔝phrases/ideas from today's III @LA_Rednetwork anual meeting

#sepsis #PICSyndrome
#PedsICU #MeetingLARed18 @juancajara78 @rjabornisky

👇
2/
Arriving at @PeluffoGiguens and we look at the board the invitation
Llegamos Fundación y vemos la cartelera

#MeetingLARed18
3/
With @Nmtvd preparing connections

#MeetingLARed18
Read 52 tweets
Starting "Voices without Frontiers" #VoicesIWS
A program by @IWS_Network to promote awareness about the challenges & lessons learned by #Immigrant and #International #WomenInScience

I was born & raised in Chicoral, Colombia. A tiny town in the middle of the Andes Cordillera.
I attended Nuestra Señora del Rosario school, located in Espinal, 15Km away from Chicoral. Due to the high heat by noon, all schools start really early back home. This meant, I had to wake up at 5am to attend school every morning since I was 4 years old. #VoicesIWS
I did well in math and science in elementary and high school, so I chose to study clinical microbiology. Although coming from a low-middle income family, I was able to attend university, thanks to my parents’ effort to prioritize education over other commodities. #VoicesIWS
Read 40 tweets
#BigData #ICU #sepsis research I wish some1 would do

Optimal Duration of Time-Limited Trials in Critically Ill Patients

"If they are going to respond to this, we should see a response by ..."

What are median + 95th percentile for responses to common life-saving therapies?
I feel like we "know" this for lots of small things
- Lasix should make 'em pee within 20 minutes
- PEEP improves oxygenation in 20 minutes
- uroseptic shock should break within 24 hour
There are some scattered superb research projects:
- optimal durations of SBTs
- optimal time to neuroprognostication s/p anoxic injury
- Blood cultures will turn positive for MRSA w/i 48 hours if they are going to
Read 6 tweets

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