I've seen someone authoritatively claim ONLY the SV40 polyA signal is present in the vaccine.
This person never looked at the sequence.
Here is the region with the SV40 promoter, The 72bp bidirectional SV40 Enhancer, and the SV40 Ori.
nature.com/articles/s4141…
SV40 origin is only active in people who have SV40 T-Antigen expressed. Many people (100M) are SV40 infected suggesting they may be present in these individuals
ncbi.nlm.nih.gov/pmc/articles/P…
There is an SV40 poly A signal downstream of the F1 origin but this is omits many of the other SV40 components in expression plasmid.
What is the F1 origin?
This can be used to make single stranded copies of the plasmid DNA for viral packaging in mammalian cells or bacterial strains.
The direction of the yellow arrow directs the + strand of synthesis.
nature.com/articles/s4141…
The above paper is where much of the cancer risk of SV40 comes from. This relates to people infected with the full 5,234 viral genome, not just the components in the expression plasmid. What happens with SV40 infected people are vaccinated?
Seroprevalence is significant.
ncbi.nlm.nih.gov/pmc/articles/P….
I don't profess to know what all this means. I know enough to know it should be disclosed given the guidelines that are in place.
This is the opposite of disclosure. No DNA sequence provided to the EMA. Just a vector map with this stuff missing.
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