10 Potent Tools to 10x Your Mitochondria
THREAD 🧵
Mitochondrial dysfunction is at the core of EVERY disease
After all, your mitochondria produce 90% of your body's energy
Why would you not want them firing on all cylinders?
So without further adu, let's jump in
As always, consult a doctor before using anything...
1) UROLITHIN A
Urolithin A is the next big thing in the biohacking & longevity space
It's one of the few potent inducers of MITOPHAGY
It supercharges natural energy production by cleaning up and recycling damaged mitochondria
Only 40% of people can produce it naturally
Urolithin A isn't just marketing hype
It actually has a ton of evidence suggesting it can improve:
- Alzheimer's & Parkinson's
- Muscle Endurance/Strength
- Cardiovascular Health
The therapeutic applications of Urolithin A are endless
Great addition if you can afford it
2) SHILAJIT
I've been using Shilajit extensively over the past 9 months
It's been a game-changer for natural energy & willpower
It's one of the few supplements you can really "feel"
But these benefits aren't solely because of its fulvic acid & mineral content...
Shilajit contains mitochondrial stimulants called dibenzo-a-pyrones (DBPs)
These miracle molecules work in tandem with CoQ10 to enhance ATP energy output
While simultaneously reducing oxidative damage to your mitochondria
Shilajit is great for:
- Vitality/libido/willpower/testosterone
- Anti-fatigue
- Physical training
But you need to buy Shilajit w/o mycotoxins & heavy metals
I recommend & personally use @BasedSupps by @erikjasperkier
Third-party tested & verified
basedsupplements.co/products/shila…
@BasedSupps @erikjasperkier 3) METHYLENE BLUE
MB is the #1 anti-aging drug
At low doses, MB turbocharges your mitochondria
It acts as an electron donor, which enhances energy output & reduces oxidative damage
I wouldn't use much more than 5mg orally
@BasedSupps @erikjasperkier MB is especially useful for cognitive health
Besides acting as an electron donor, it also increases acetylcholine & monoamines
Thanks to these 3 mechanisms, it holds promise in preventing neurodegeneration
And even improves memory even in healthy adults
@BasedSupps @erikjasperkier Ensuring purity is crucial when using MB
Even pharmaceutical-grade MB often contains heavy metals
That's why I use Meraki Blu from @VanceE which is USP-grade MB and lab tested for impurities
Don't use MB with serotonergic antidepressants
merakimedicinal.com/NOOTROPICGUY
@BasedSupps @erikjasperkier @VanceE 4) MITOQ
MitoQ = CoQ10 on steroids
MitoQ is simply a smaller version of CoQ10 with a positive charge
And thus it can easily cross the mitochondrial membrane and work its magic
(unlike CoQ10)
Once inside replenishes CoQ10 & enhances ATP production as its an electron donor
@BasedSupps @erikjasperkier @VanceE If you can afford it, I'd use MitoQ over CoQ10 or Ubiquinol
- 19 human clinical trials
- 750+ peer-reviewed scientific papers
- $60mm+ of independent studies
& has been shown in humans to improve:
- Cardiovascular function
- Kidney health
- Athletic performance
- & more
@BasedSupps @erikjasperkier @VanceE 5) PQQ
PQQ = CoQ10's cousin
PQQ works a bit differently though
Rather than protecting & enhancing existing mitochondria...
PQQ actually increases the formation of NEW mitochondria
(aka mitochondrial biogenesis)
@BasedSupps @erikjasperkier @VanceE As seen below, PQQ is proven to increase mitochondrial biogenesis in humans
(via the PGC-1a & CREB pathways)
PQQ also:
- 100x more antioxidant than Vit C
- Lowers CRP by 45% in 3 weeks
- May improve sleep/cognition
PQQ is decent, but I much prefer the next one
@BasedSupps @erikjasperkier @VanceE 6) SALIDROSIDE
Salidroside = Rhodiola's key bioactive
It's like miracle grow for your dopaminergic system
(via enhancing GDNF, CDNF, & tyrosine hydroxylase)
And like PQQ, it also increases the formation of new mitochondria
@BasedSupps @erikjasperkier @VanceE Because of its mitochondrial-enhancing & neurogenic properties, salidroside (LK-01) has been shown to:
- Improve mood
- Reduce mental fatigue
- Enhance athletic performance
- Enhance physical endurance
Salidroside works best when held under the tongue & consumed sublingually
@BasedSupps @erikjasperkier @VanceE 7) RESVERATROL
PQQ/Salidroside = mitochondrial biogenesis
Resveratrol = mitochondrial fission/fusion
Mitochondrial fusion is when mitochondria merge to form larger, more efficient mitochondria
Fission = 1 mitochondrion splitting into multiple (usually for quality control)
@BasedSupps @erikjasperkier @VanceE Fission/Fusion can dilute out damaged components, improving overall function and reducing the need for mitophagy
Larger mitochondria are also more efficient in energy production
If you have cardiovascular issues, I would absolutely consider Resveratrol
@BasedSupps @erikjasperkier @VanceE 8) MOTS-c
Now onto the fun stuff
MOTS-c is my favorite compound in this thread
And belongs to the mitochondrial-derived peptide (MDP) class
You can think of MDPs as mitochondrial hormones
MDPs are encoded by mitochondrial DNA
Normal peptides are encoded by nuclear DNA
@BasedSupps @erikjasperkier @VanceE This means MDPs are especially good at regulating mitochondrial processes
But not all MDPs do the same thing
MOTS-c in particular is akin to "exercise in a bottle"
- Fat loss
- Physical performance/endurance
- Anti-fatigue
- Longevity
In fact, MOTS-c levels are low in CFS
@BasedSupps @erikjasperkier @VanceE 9) HUMANIN
Humanin is an MDP like MOTS-c
But whereas MOTS-c = metabolic MDP...
Humanin = neurological MDP
If you want to prevent & even reverse dementia, Humanin is your guy
In fact, it was named Humanin because it restored the “humanity” of patients with Alzheimer’s
@BasedSupps @erikjasperkier @VanceE Humanin enhances mitochondria by:
- Reducing mitochondrial ROS
- Inhibiting cytochrome C release
- Enhancing ATP output
- Inducing mitochondrial biogenesis
- Preventing cell death
It's like growth hormone for your mitochondria
But interestingly, actual GH use lowers Humanin
@BasedSupps @erikjasperkier @VanceE As mentioned, Humanin is especially useful for brain health
It even binds directly to the Ciliary Neurotrophic Factor (CNTF) receptor
(CNTF is like BDNF on steroids)
Also:
- Inhibits brain insulin resistance (T3D)
- Reverses memory loss
- Reduces neuroinflammation
@BasedSupps @erikjasperkier @VanceE 10) SS-31
Last but not least is SS-31
This is the MDP for mitochondrial integrity
SS-31 binds to something called cardiolipin in the inner mitochondrial membrane
This essentially optimizes the electron transport chain
And increases ATP energy output & protects mitochondria
@BasedSupps @erikjasperkier @VanceE SS-31 has been studied extensively with about 140 studies published since 2005
According to this research, SS-31 may be able to
- Reverse/halt neurodegeneration
- Improve physical performance
- Reduce fatigue
- Reduce Type 2 Diabetes
Useful in severe mitochondrial dysfunction
@BasedSupps @erikjasperkier @VanceE Recap:
Urolithin A = mitophagy
Shilajit = enhances CoQ10
Methylene Blue = electron donor
MitoQ = electron donor
PQQ = mitochondrial biogenesis
Salidroside = also biogenesis
Resveratrol = mito fusion
MOTS-c = metabolic MDP
Humanin = neurological MDP
SS-31 = mito integrity MDP
@BasedSupps @erikjasperkier @VanceE If you found this helpful, toss me a RT & like on the original tweet for the algo
Will also be answering any questions related to this thread in the comments
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