1. Nitric Oxide (NO) pathway rise in interest in the health and performance fields. Diverse supplementation approaches ignite NO production, yielding multiple benefits, including adaptations from cell metabolism to whole-body physiology.
2. As physiologists, we have been always interested in the topic and some years ago we started a series of humble studies led by @MielgoAyuso, researching an emerging area: combined supplementation protocols to optimise NO pathway performance.
Let me introduce you:
3. We started publishing a systematic review and meta analysis in 2 main amino-acids participating in the NO pathway (Arginine and Citrulline).
Arginine:
Citrulline:
That was already interesting to see isolated effects. pubmed.ncbi.nlm.nih.gov/32370176/
ncbi.nlm.nih.gov/pmc/articles/P…
4. What about nitrate? We continue with some experiments, and J.Burgos took the lead in interesting studies researching the impact of a combined supplementation of Citrulline and Nitrate, in different performance outcomes in highly trained athletes.
Those studies were published.
5. In the first one performance outcomes were studied after a chronic (9 weeks) of combined supplementation (citrulline + nitrates) in comparison with a placebo, a nitrate and citrulline supplementation groups.
Check it here:
pubmed.ncbi.nlm.nih.gov/35010917/
6. Second study showed humble benefits in recovery status in same population (trained triathletes) using same protocol.
You can check it here:
pubmed.ncbi.nlm.nih.gov/35053073/
7. Now, what are we exploring at the moment to continue this line?
- Is combined supplementation a better protocol than isolated supplementation?
- How long does it takes to get benefits?
- Are 9 weeks necessary?
- What about metabolic outcomes? How can this impact on them?
8. We took a whole professional rowing team and we started to investigate all that.
First paper has been submitted. The results are intriguing in a field where many questions remain unanswered.
Answers? Soon (if we are able to publish).
Thanks!!! NO pathway is cool!
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