SARS-COV-2 hijacks cells, forces them to grow TENTACLES, then INVADE others ! 😨
2) Filopodia : High-resolution imaging of the infected cells showed that the cells had grown tentacle-like protrusions called "filopodia," which contained viral proteins.
One of the first study on this topic was from the famous Krogan lab.
cell.com/cell/fulltext/…
3) Then there was this incredible study with three dimensional pictures of filopedia
link.springer.com/article/10.100…
4) ... or this three-dimensional reconstruction from 14 serial electron micrographs with an overview of cell–cell interaction in viral propagation.
5) There was also this study with amazing pictures, as if they had been taken from another planet
"An intra-cytoplasmic route for SARS-CoV-2 transmission unveiled by Helium-ion microscopy"
nature.com/articles/s4159…
6) It is a key topic to understand the access of SARS-COV-2 in the brain.
"Tunneling nanotubes provide a route for SARS-CoV-2 spreading"
Fig. SARS-CoV-2 can reach SH-SY5Y neuronal cells from Vero E6 permissive cells science.org/doi/10.1126/sc…
7) To end on a slightly less dramatic or serious note, I even discovered that the virus WAS "SURFING" 😊
Thanks for reading 🙏
Fig. Conceptual scheme of a viral surfing and the intracellular pathway in TNT. b Viral surfing along filopodial bridges
8) Others references:
SARS-CoV-2 infected cells sprout actin-rich filopodia that facilitate viral invasion
FYI
@DavidJoffe64 @UseBy2022
@shay_fleishon @siamosolocani @LongDesertTrain
@SystemsVirology
@mrmickme
@outbreakupdates
@RadCentrism
@MeetJess biorxiv.org/content/10.110…
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