Never be afraid to raise your voice for honesty and truth and compassion against injustice and lying and greed. William Faulkner
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Jul 6 โข 6 tweets โข 3 min read
The HISTAMINE RECEPTOR H1 ACTS as an ALTERNATIVE RECEPTOR for SARS-CoV-2
Great thanks to @mryoung151
for this study ๐ journals.asm.org/doi/10.1128/mbโฆ 2) This study found that the histamine receptor H1 (HRH1) can act as an alternative entry point for the SARS-CoV-2 virus to infect cells, in addition to the main receptor ACE2.
The researchers screened approved drugs and discovered that antihistamine drugs ...
Jul 6 โข 4 tweets โข 2 min read
WHAT TREATMENTS WORK AGAINST COVID-19? ๐ฏ๐ฅ๐
Everything you want to know is here ๐
WHO ARE THEY?
They are a group of PhD researchers, scientists, and individuals dedicated to making a contribution, no matter how small. c19early.org 2) Their research can be found in reputable journals like Science and Nature.
WHAT TREATMENTS DO THEY RECOMMEND?
They cannot provide medical advice but recommend to consult a qualified physician who can give personalized recommendations based on your medical history and ...
Jul 6 โข 5 tweets โข 2 min read
23-YEAR ANALYSIS of the STATISTICAL CONTROL CHARTS in EPIDEMIOLOGICAL MONITORING, with a focus on the COVID-19 pandemic.
journals.lww.com/md-journal/fulโฆ 2) Key findings:
- Control chart usage in epidemiology increased significantly during the COVID-19 pandemic, peaking in 2021-2023 (18%, 36%, 41% of applications respectively).
- Commonly monitored variables include influenza, Salmonella, infection rates, as well as COVID-19 ...
Jul 6 โข 6 tweets โข 2 min read
WHY the SAME VACCINE DOSE for EVERYONE?
This small study shows that kidney transplant patients can have very different responses to the same vaccines. Some developed protective antibody levels, while others did not, even with the standard vaccine doses. journals.lww.com/md-journal/fulโฆ 2) The findings suggest we can't just give everyone the same vaccine schedule. Each person's immune system may respond differently. Some may need extra vaccine doses to build up enough antibodies for protection.
Personalized Vaccine Schedules Could Help
Jul 5 โข 4 tweets โข 2 min read
SEARCH TRAFFIC for INFLATABLE PENILE PROSTHESIS increased following the COVID-19 PANDEMIC in the US: a Google Trends analysis
nature.com/articles/s4144โฆ 2) This study analyzed Google Trends data to examine the impact of the COVID-19 pandemic on public interest in inflatable penile prosthesis (IPP) in the US. Prior to the pandemic, there was a consistent upward trend in IPP searches, concentrated in metropolitan areas with ...
Jul 5 โข 9 tweets โข 3 min read
SPIKE DEEP MUTATIONAL SCANNING HELPS PREDICT SUCCESS of SARS-CoV-2 CLADES ๐ฏ๐
A GROUNDBREAKING STUDY conducted by @jbloom_lab and his colleagues sheds light on crucial aspects of the pandemic. nature.com/articles/s4158โฆ 2) The study focuses on two key areas:
โถ๏ธ The impact of Spike mutations, both within and outside the RBD, on immune system evasion, and
โถ๏ธ How these mutations affect individuals with diverse immunological profiles.
This study is in our opinion, one of the most significant
Jul 4 โข 7 tweets โข 3 min read
What if PEPTIDES were KEY ELEMENTS ?
(2nd part) 2) In this study,
they investigated the potential neurotoxic effects of SARS-CoV-2 spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial models during brain development. sciencedirect.com/science/articlโฆ
Jul 4 โข 10 tweets โข 4 min read
What if PEPTIDES were KEY ELEMENTS during SARS-COV-2 INFECTION?
(1st part)
Peptides are short chains of amino acids and they play a crucial role in the interaction between SARS-CoV-2, the virus that causes COVID-19, and the human body. 2) Peptides are involved in several key processes:
- Viral Entry: SARS-CoV-2 enters human cells by binding to the ACE2 receptor on the surface of the host cells. Peptides derived from the ACE2 receptor can potentially block the interaction between the virus and the receptor,
Jul 4 โข 6 tweets โข 3 min read
TISSUE-BASED T CELL ACTIVATION and viral RNA PERSIST for up to 2 YEARS after SARS-CoV-2 INFECTION
(complete summary - Thanks to @DavidJoffe64)
SARS-CoV-2 spike identified in rectosigmoid tissue of individuals with LC months to years after acute infection science.org/doi/10.1126/scโฆ 2) The study used PET imaging with a radiotracer called [18F]F-AraG to detect activated T cells in a cohort of 24 participants at different time points after COVID-19 infection, including those with and without Long COVID symptoms.
Jul 4 โข 5 tweets โข 2 min read
DECAY RATES of INFECTIOUS SARS-CoV-2 virus and its RNA in different WATER TYPES (wastewater, lake water, marine water) and at VARYING TEMPERATURES (4ยฐC, 25ยฐC, 37ยฐC).
sciencedirect.com/science/articlโฆ 2) Key findings :
- Infectious SARS-CoV-2 decayed significantly faster than viral RNA across all conditions. At 37ยฐC, no infectious virus was detected after 24 hours.
- Temperature was the primary driver of decay, with higher temperatures accelerating the loss ...
Jul 3 โข 5 tweets โข 2 min read
IN-HOSPITAL DELIRIUM After COVID-19 HOSPITALIZATION ๐จ
jamanetwork.com/journals/jamanโฆ 2) This study examined the association between in-hospital delirium and functional disability as well as cognitive impairment in older adults hospitalized for COVID-19. The researchers followed a cohort of 311 patients aged > 60 for 6 months after their COVID-19 hospitalization.
Jul 2 โข 5 tweets โข 2 min read
A very strong increase of a neurodevelopmental DISORDER affecting CHILDREN: 2 times more ADHD during COVID-19 pandemic !
jamanetwork.com/journals/jamanโฆ 2) The study investigated trends in new ADHD diagnoses, prevalence, and medication use in Finland before and during the COVID-19 pandemic. Using nationwide health registers, the researchers found:
- New ADHD diagnoses doubled during the pandemic ...
Jul 2 โข 4 tweets โข 2 min read
I LOVE MY HONEY ! ๐
"Honey microbiota, methods for determining the microbiological composition and the antimicrobial effect of honey" sciencedirect.com/science/articlโฆ 2) Honey is a natural product with antimicrobial, antiviral, and antiparasitic properties. Its microbiota includes beneficial bacteria, yeasts, and molds, as well as potential pathogens.
Jul 2 โข 4 tweets โข 2 min read
IMPRINTING of IgA RESPONSES in PREVIOUSLY INFECTED individuals RECEIVING BIVALENT mRNA VACCINES
Not good news at all ! ijidonline.com/article/S1201-โฆ 2) Bivalent mRNA boosters induce lower IgA responses against Omicron variants compared to monovalent boosters, but only in previously infected individuals. The relative fold change in IgA is more skewed towards ancestral spike than variant spike in bivalent-boosted ...
Jul 2 โข 6 tweets โข 2 min read
IMPACT of SARS-COV-2 on the LIVER!
Cellular damage and long term complications
Direct COVID-19 liver injury is observed through various histopathological changes. After analyzing several cohorts of liver biopsies, the most common findings associated ... wjgnet.com/1007-9327/fullโฆ 2) ...with SARS-COV-2 hepatic infection were reported and described.
I: Centrilobular areas of confluent necrosis.
II: The inflammatory infiltrate surrounding necrosis showed lymphoplasmacytic infiltrate with histiocytes, few eosinophils, and neutrophils.
โถ๏ธ ๐พ๐๐๐-๐๐๐๐ ๐ฐ๐ณ
โถ๏ธ ๐พ๐๐๐-๐๐-๐พ๐๐๐ 2) SARS-CoV-2 can spread through both cell-free transmission and cell-to-cell transmission (direct contact between infected and uninfected cells)
Thanks to @jlerollblues academic.oup.com/jid/advance-arโฆ 2) Post-COVID conditions (PCC) are challenging to understand and manage due to overlapping symptoms and unclear pathology. This study analyzed 1,988 individuals with post-COVID symptoms and identified three distinct symptom clusters: sensory symptoms, fatigue/difficulty thinking
๐ ๐ฌ๐ฆ๐บ ๐ด๐ต๐ถ๐ฅ๐บ ๐ฃ๐บ ๐ฐ๐ฏ๐ฆ ๐ฐ๐ง ๐ฎ๐บ "๐ฎ๐ข๐ด๐ต๐ฆ๐ณ๐ด" ๐ฐ๐ฏ ๐ต๐ฉ๐ช๐ด ๐ด๐ถ๐ฃ๐ซ๐ฆ๐ค๐ต : ๐๐ข๐ง๐ข๐ฆ๐ญ ๐๐ข๐ฏ๐ซ๐ถ๐ข๐ฏ spj.science.org/doi/10.34133/2โฆ 2) Viruses can exhibit a range of cooperative and competitive interactions, which often occur in cells co-infected with multiple viral variants.
Some key points of this study :
- Cooperative interactions include genetic complementation, pseudotyping, and ...
"๐๐ค๐ข๐๐๐" ๐ซ๐๐ง๐ช๐จ ๐๐ง๐๐๐ข๐๐ฃ๐ฉ๐จ ๐ธ๐ฉ๐ช๐ค๐ฉ ๐ค๐ฐ๐ฏ๐ต๐ช๐ฏ๐ถ๐ฆ ๐ต๐ฐ ๐ค๐ข๐ถ๐ด๐ฆ ๐ช๐ฏ๐ง๐ญ๐ข๐ฎ๐ฎ๐ข๐ต๐ช๐ฐ๐ฏ ๐ข๐ง๐ต๐ฆ๐ณ ๐ต๐ฉ๐ฆ ๐ท๐ช๐ณ๐ถ๐ด ๐ช๐ด ๐ฅ๐ฆ๐ด๐ต๐ณ๐ฐ๐บ๐ฆ๐ฅ 2) According to our opinion, one of the most concerning subjects is the discovery of two possibilities regarding the fragments of the SARS-CoV-2 virus. Firstly, these fragments, generated after the virus is broken down, mimic a crucial component of the body's immune system ...
The "iceberg model" mdpi.com/1422-0067/25/1โฆ 2) Long COVID (LC) is a complex multisystem disease with diverse symptoms, characterized by low-grade inflammation as a core pathogenetic mechanism. LC lacks clear clinical boundaries and standardized management protocols, complicating its description.