Never be afraid to raise your voice for honesty and truth and compassion against injustice and lying and greed. William Faulkner
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Apr 26 • 7 tweets • 3 min read
No, Omicron is not the "humanized" SARS-COV-2 !
(Explanation in simple terms) biorxiv.org/content/10.110…2) Viruses are not living things. They are tiny particles that can only make copies of themselves inside the cells of living things, like humans. When a virus makes copies of itself, it doesn't always make perfect copies.
Apr 26 • 6 tweets • 2 min read
"What if humans had sent SARS-COV-2 into space, or even brought COVID-19 along for astronauts?"
Space travel is becoming more common, with over 600 people having gone to space. But COVID-19 could be a big problem for astronauts in the unique environment of space.
Apr 24 • 5 tweets • 2 min read
From Lung Damage to Gut Dysbiosis:
The Lasting Implications of SARS-CoV-2 Variant-Specific Microbiome Changes (From Wuhan strain to Omicron) labanimres.biomedcentral.com/articles/10.11…2) The Wuhan strain of SARS-CoV-2 caused serious damage to the lungs of infected mice. The mice had a very high chance of dying from this strain. The researchers also looked at the bacteria in the lungs and guts of the infected mice.
Apr 23 • 10 tweets • 4 min read
What are GAMMA CORONAVIRUSES ?
And why did we decide to talk about it? 2) A brief reminder :
▶️ SARS-CoV-2 belongs to the family Coronaviridae, is classified as a coronavirus and is responsible for COVID-19
▶️ Bird Flu refers to various strains of the influenza virus, particularly those in the Orthomyxoviridae family including H5N1 and H7N9.
Apr 21 • 4 tweets • 2 min read
A TREATMENT that Could Finally END Long COVID Suffering ?
This isn't the first time a treatment has been announced, and as millions continue to struggle with long Covid, we need to remain both cautious and hopeful 🤗 2) Researchers at WEHI announced that they discovered a new drug that can stop long COVID symptoms in mice. This drug is more effective than the current top treatment, Paxlovid, for both long COVID and acute COVID cases.
Apr 21 • 8 tweets • 2 min read
Experts Provide (finally !) Roadmap to Address the Complexities of Long COVID
... with top experts👍as @AndrewEwing11 @DavidJoffe64 and the Long COVID consensus expert panel 💥💯 ann-clinmicrob.biomedcentral.com/articles/10.11…2) Long COVID is a complex condition that affects many people after they have had COVID-19. It can cause a wide range of symptoms that last for a long time. There are not many clear guidelines on how to diagnose and treat Long COVID.
Apr 20 • 6 tweets • 3 min read
We're not about to feel bad for SARS-CoV-2 infecting us humans. But let's be real - the life of a virus isn't exactly a walk in the park 🥴
These little buggers are constantly trying to "have their cake and eat it too."
(An astonishing study 👇💥💯) virologyj.biomedcentral.com/articles/10.11…2) On one hand, they need to spread like wildfire from person to person. But on the other hand, they also have to make tons of copies of themselves inside each infected host.
Not an easy balance to strike, is it?
Apr 20 • 10 tweets • 4 min read
WHY is it IMPOSSIBLE to COMPLETELY ELIMINATE the SARS-CoV-2 virus? (Final part)
What if my question concerning viral persistence was not asked properly? 2) Let me try to explain in simple words.
Viral persistence refers to the ability of some viruses to stay in the body for a long time, often even after the initial infection has cleared. This means that the virus can remain in certain tissues or cells and ...
Apr 20 • 5 tweets • 2 min read
WHY is it IMPOSSIBLE to COMPLETELY ELIMINATE the SARS-CoV-2 virus? (3rd part)
Simply because SARS-CoV-2 is a very sneaky and persistent virus. It has evolved ways to hide from and even manipulate our immune system to its advantage.
Just an example ... nature.com/articles/s4159…2) Imagine that SARS-COV-2 succeed to hide inside certain immune cells called macrophages in the lungs, and then spreads from one macrophage to another, allowing it to persist for a very long time.
But it also disrupts the normal functioning of immune cells like NK cells and ...
Apr 19 • 7 tweets • 3 min read
WHY is it IMPOSSIBLE to COMPLETELY ELIMINATE the SARS-CoV-2 virus?
(2nd part for Kids)
Since this study is highly significant in its field, we try to summarize it in a way that is accessible to everyone, including children
From @sigallab @richardneher nature.com/articles/s4157…2) Our body is able to fight off viruses that's making you sick.
But sometimes, a virus like SARS-CoV-2, can stay in a person's body for a really long time, even after they've gotten over the worst of their illness. This is called "viral persistence."
Apr 19 • 14 tweets • 5 min read
WHY is it IMPOSSIBLE to COMPLETELY ELIMINATE the SARS-CoV-2 virus?
What causes the virus or its remnants to linger in our bodies even after a mild or asymptomatic infection?
(1st part : "The persistence")
This discussion will address these questions through multiple threads... 2) ...drawing from a wealth of published research due to the intricacy of the topic.
To start, we’ll present a concise overview of five key studies that demonstrate the virus's persistence for weeks or even months following infection.
Apr 18 • 7 tweets • 2 min read
"Now this is not the end. It is not even the beginning of the end" (Winston Churchill)
This study shows that the Sarbecoviruses have the capacity to generate new variants rapidly, with RBD of two novel viral groups exhibiting high similarity to SARS-CoV-2 biorxiv.org/content/10.110…2) Over 3 years, researchers sampled 1,462 bats in Cambodia Steung Treng province, identifying extensive and diverse coronaviruses co-circulation. Using metatranscriptomic and amplicon sequencing, they generated 33 complete sarbecovirus genomes.
Apr 18 • 8 tweets • 2 min read
Doctor, I'm confused 🤔
I have a high level of antibodies, yet I'm still experiencing long COVID. Why is that?
"The ANTIBODIES PARADOX in LONG COVID Condition: Unraveling the Disconnect Between Humoral Immunity and Chronic Illness" nature.com/articles/s4146…2) The finding in this study of persistently higher anti-N antibody levels in people with Post-Covid Condition (PCC) compared to those with acute infection only, does seem paradoxical at first glance.
Apr 17 • 11 tweets • 4 min read
The incredible world of T-CELLS and why are they exhausted fighting the SARS-COV-2 virus ?
(An explanation🧵 for kids based on an astonish study Thanks to @DavidJoffe64) sciencedirect.com/science/articl…2) T-cells are like the superheroes of our immune system - they work hard to protect us from germs and viruses.
When a virus like SARS-COV-2 gets into our body, the T cells spring into action. There are different types of T cells, each with a special job to do.
Apr 16 • 6 tweets • 3 min read
"COVID-19 CRUSADERS:
The TRIO of NASAL IMMUNE CELLS That BATTLE the VIRUS"
A masterpiece study in Nature 💯💥 nature.com/articles/s4159…2) The most important immune components in the nasal tissue for fighting COVID-19 are:
▶️ Monocytes and neutrophils
- These immune cells moved into the area under the nose lining during active COVID-19 infection and helped protect the underlying lymphoid tissue.
Apr 16 • 7 tweets • 3 min read
How SARS-COV-2 spreads (Re) and why there are differences between countries ?
An explanation for kids based on the astonishing new study of @firefoxx66 @richardneher and colleagues pubmed.ncbi.nlm.nih.gov/40233303/2) With a really fast-spreading virus going around, like the one that causes COVID-19, when someone gets sick, they can pass the virus to other people. But some sick people end up spreading it to a lot more people than others.
Apr 12 • 4 tweets • 2 min read
STRUCTURAL BRAIN CHANGE with LONG COVID 😰
Brain scans of Long COVID patients showed reduced volumes in critical brainstem regions like superior and middle cerebellar peduncles, along with decreased connectivity.
These structural and functional changes were linked to motor ... 2) ... sensory, and autonomic dysfunction in patients. Researchers propose a "Broken Bridge Syndrome" where COVID-19 disrupts the vital connection between the brainstem and cerebellum, contributing to the diverse neurological symptoms of Long COVID.
Apr 12 • 7 tweets • 3 min read
SURPRISING T CELLS !
This study looked at the immune response to COVID-19 vaccines and natural infection. It found that both vaccines and prior infection can generate strong T cell responses that recognize different parts of the virus. biorxiv.org/content/10.110…2) These T cell responses are important for fighting off the virus, even as it mutates.
The study first looked at people who got the mRNA COVID-19 vaccines. It found that the vaccines quickly induced T cells that could produce multiple immune molecules like interferon-gamma ...
Apr 11 • 5 tweets • 2 min read
CANCER+ COVID-19 !
The Increased Risk of Viral Co-Infections (Herpesviruses (HHV) and Measles Virus (MeV)) in Cancer Patients with COVID-19 jenci.springeropen.com/articles/10.11…2) Herpes viruses, like the one that causes cold sores, were 3 times more common in cancer patients with COVID-19 compared to others. Nearly 30% of cancer patients with COVID-19 had the herpes virus reactivate, while it didn't reactivate at all in non-cancer patients with COVID
Apr 9 • 6 tweets • 2 min read
When the virus SARS-COV-2 uses the main cities as hubs !
(This study analyzed over 130,000 COVID-19 virus samples collected in Massachusetts from November 2021 to January 2023) medrxiv.org/content/10.110…2) SARS-CoV-2 leverages major cities as hubs to spread across regions. New variants are often first introduced into populous urban areas, which then act as central points for rapid dissemination to surrounding suburbs and other regional cities.
Apr 8 • 5 tweets • 2 min read
They believed that these children were free of the SARS-COV-2 virus.
Unfortunately, it was lurking in the gut, leading to liver inflammation ! 😞 gut.bmj.com/content/early/…2) The researchers found that the children with severe liver inflammation had very high levels of a type of immune cell called CD8 T-cells in their livers.
CD8 T-cells are important for fighting viral infections. When the body detects a virus, it activates these CD8 cells ...