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Never be afraid to raise your voice for honesty and truth and compassion against injustice and lying and greed. William Faulkner
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Nov 17 4 tweets 2 min read
H5N1 is currently a ZOONOTIC OUTBREAK, NOT A PANDEMIC !!!

For over two years, we have been raising concerns about the transmission of this virus from birds to mammals, and subsequently to humans.

At this time, H5N1 remains a zoonotic outbreak, which is characterized by ... Image 2) ...a sudden rise in disease cases from animals to humans within a specific area or population.
Even if we are at stage 3 in the virus's progression, (as I indicated in my last thread 👇), for H5N1 to be classified as a pandemic ...
Nov 16 5 tweets 2 min read
"BRAIN-WIDE ALTERATIONS revealed by spatial transcriptomics and proteomics in COVID-19 INFECTION"

A key study ! 💯👍Thanks to @DavidJoffe64
nature.com/articles/s4358…Image 2) The study examined brain tissue from COVID-19 patients and found:
- Low levels of the virus in the brain, suggesting the neurological effects are not mainly due to direct viral infection.
- Widespread problems with energy production and communication between brain cells ... Image
Nov 15 12 tweets 4 min read
VIRION MORPHOLOGY and ON-VIRUS SPIKE PROTEIN STRUCTURES of diverse SARS-CoV-2 VARIANTS

An amazing study of @PeacockFlu and colleagues 💯👍
embopress.org/doi/full/10.10…Image 2) Brief summary :
The evolution of SARS-CoV-2 variants has led to structural changes in Spike protein, key for immune response. High-resolution cryo-EM analysis of variants like Alpha and Delta showed no virion morphology changes, but amino acid shifts affected spike dynamics. Image
Nov 15 6 tweets 2 min read
SARS-CoV-2 INFECTION RATES in kids in northern Germany from December 2020 to August 2022.

They found that 25.1% had antibodies, with a 5.4% silent infection rate, mainly among adolescents, influenced by household infections.
buff.ly/3O9ec8jImage 2) Amazing figures in this study

Figure 2: Anti-SARS-CoV-2 IgG response and seropositivity Image
Nov 13 7 tweets 3 min read
AN ASTONISHING STUDY 💯👍

Pro-inflammatory CYTOKINE IL-1β can potently INHIBIT SARS-CoV-2-induced CELL-CELL FUSION and viral transmission, revealing a critical ANTIVIRAL FUNCTION of INNATE IMMUNE factors.
biorxiv.org/content/10.110…Image 2) The study found that immune cells release factors that can prevent the fusion of SARS-CoV-2-infected cells with neighboring cells, a process called syncytia formation. This is important because syncytia can help the virus spread more easily. Image
Nov 13 5 tweets 2 min read
How H5N1 virus IS EVOLVING to EVADE our MEDICAL DEFENSES ?

Soon, another pandemic ?
biorxiv.org/content/10.110…Image 2) This study used computer simulations to understand how the H5N1 influenza virus is changing over time. The researchers looked at how 1,804 different versions of the virus' key protein (hemagglutinin) interact with 11 antibodies that can neutralize the virus. Image
Nov 13 4 tweets 2 min read
How SEVERE a person's COVID-19 ILLNESS will be, based on the GENETICS of the SARS-CoV-2 VIRUS ?

The model was trained on a large dataset of over 158,000 virus genome sequences and patient details collected over 4 years !
nature.com/articles/s4159…Image 2) The key findings are:
- The model identified over 40 specific mutations in the SARS-CoV-2 genome that increase the risk of severe COVID-19 illness.
- Certain mutations in the virus's spike protein, nucleocapsid protein, and other genes were linked to more severe disease. Image
Nov 13 4 tweets 2 min read
The regulatory role of SARS-CoV-2 INFECTION in solid TUMOR PROGRESSION, including LUNG, COLON, KIDNEY, and LIVER CANCERS

An astonishing study ! 💯👍
molecular-cancer.biomedcentral.com/articles/10.11…Image 2) This study found that SARS-CoV-2 infection can inhibit the growth and spread of certain solid tumors, including colon and kidney cancers. The key mechanism involves the SARS-CoV-2 nucleocapsid (N) protein, which can interact with a protein called YBX1. Image
Nov 13 4 tweets 1 min read
Association between sore throat and early immune responses against COVID-19 before and after the emergence of the Omicron variant

atm.amegroups.org/article/view/1…Image 2) The study investigates the link between sore throat symptoms and immune responses in COVID-19 patients, particularly focusing on the Omicron variant. It involved 183 hospitalized patients between December 2020 and April 2022, covering both pre-Omicron and Omicron periods.
Nov 12 6 tweets 3 min read
How natural antibodies from B-1 cells, recognize a conserved viral glycan, to broadly neutralize endogenous retroviruses and enveloped viruses, providing innate antiviral immunity ?

A very interesting study of @VirusesImmunity and colleagues
science.org/doi/10.1126/sc…Image 2) This study found that the body's natural antibodies, produced by B-1 cells, help prevent the reactivation of endogenous retroviruses (ERVs) that are present in the genome. Image
Nov 12 6 tweets 1 min read
On the cusp of the silent wave of the long COVID pandemic: why, what and how should we tackle this emerging syndrome in the clinic and population?

Editorial
frontiersin.org/journals/publi… 2) The editorial discusses the growing public health issue of "long COVID" - the persistent health problems experienced by many people after a COVID-19 infection. Key points:

Long COVID is a new medical condition characterized by symptoms like extreme fatigue, difficulty with...
Nov 10 7 tweets 3 min read
Visual preferences for communicating modelling: a study of Covid-19 policy and decision makers

medrxiv.org/content/10.110…Image 2) This study looked at how scientists can better communicate COVID-19 modelling results to policymakers. Interviews with modellers and decision-makers across 13 countries found a few key principles. Image
Nov 10 6 tweets 3 min read
Why age-related gut imbalances contribute to the increased vulnerability and poor recovery from COVID-19 in the elderly ?

biorxiv.org/content/10.110…Image 2) This study found that older hamsters have an imbalanced gut microbiome even before getting infected with SARS-CoV-2. When infected, the older hamsters had much higher virus levels in their lungs and more severe lung damage compared to younger hamsters. Image
Nov 9 5 tweets 2 min read
Impact of SARS-CoV-2 Variants on COVID-19 Symptomatology and Severity during five waves.

H/t @atranscendedman
cell.com/heliyon/fullte…Image 2) This study examined how different COVID-19 variants affected symptoms, severity, and outcomes over time in Serrana, Brazil. Key findings:

- Patients infected during the Delta wave were the youngest, while the Gamma wave had the highest deaths. Image
Nov 9 5 tweets 2 min read
Fatigue >12 weeks after coronavirus disease (COVID) is associated with reduced reward sensitivity during effort-based decision making

biorxiv.org/content/10.110…Image 2) This study looked at how fatigue and depression affect decision-making in people who had COVID-19. It found that those who had COVID >12 weeks ago reported more fatigue and were less sensitive to rewards compared to others. Image
Nov 9 5 tweets 2 min read
LONG COVID up to FOUR YEARS POST-COVID-19 INFECTION in YOUNG STUDENTS !

medrxiv.org/content/10.110…Image 2) The study looked at how COVID-19 affects the long-term health and thinking abilities of young university students. It found that some problems, like fatigue in women and memory issues in men, can last for years after infection, especially with the Wuhan variant. Image
Nov 9 6 tweets 2 min read
SARS-CoV-2 JN.1 reveals attenuated pathogenicity and airborne transmission

biorxiv.org/content/10.110…Image 2) The SARS-CoV-2 variant JN.1 has become the dominant global strain, but animal studies indicate it has lower pathogenicity and transmission compared to earlier Omicron variants.

In cell cultures, JN.1 replicated more efficiently than the original Omicron BA.2 strain, and ... Image
Nov 9 13 tweets 3 min read
H5N1 AVIAN INFLUENZA

All the latest studies in 1 mega-thread🧵
11 studies from October to November 2024 Image 2)
Nov 9 7 tweets 2 min read
The PROLONGED JOURNEY of SARS-COV-2 in ESTABLISHING ITSELF as the LEADING HUMAN PATHOGEN !

Mega-thread🧵 6 key studies Image 2)
Nov 9 6 tweets 2 min read
IF WE COULD PREVENT the SARS-COV-2 virus from ENTERING OUR CELLS, we could effectively BLOCK the INFECTION

Mega-thread🧵 5 key studies Image 2)
Nov 8 5 tweets 3 min read
H5N1 versus SARS-COV-2
A "DOUBLE PANDEMIC" ?

Recent mutations in H5N1 and SARS-CoV-2 raise concerns for public health. H5N1 mutations can increase human infection risk, while SARS-CoV-2 variants show enhanced transmissibility and vaccine evasion.

H5N1 (left) SARS-COV-2 (right) Image
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2) H5N1 is a bird flu that mainly affects birds, but it can infect cattle. In the U.S., there have been more and more cases of this happening. Image
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