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Never be afraid to raise your voice for honesty and truth and compassion against injustice and lying and greed. William Faulkner
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Apr 1 10 tweets 4 min read
BRAIN'S BATTLE: 5 Ways COVID-19 Can Disrupt Cognition 😰
1. Persistent neuroinflammation
2. Cerebrovascular complications
3. Direct neuronal injury
4. Activation of the kynurenine pathway
5. Psychological distress

(Visual explanations 💥💯)
onlinelibrary.wiley.com/doi/10.1111/cn…Image 2) This first figure helps explain the first key mechanisms contributing to cognitive impairment in COVID-19 patients:

▶️ Direct viral entry and brain injury is shown in the first panel.
▶️ The role of hypoxia (lack of oxygen) in cognitive decline is depicted in the second panel Image
Mar 31 8 tweets 3 min read
For CHILDREN, the risk of LONG COVID after a SECOND INFECTION is 2.08 TIMES GREATER compared to the FIRST INFECTION.
medrxiv.org/content/10.110…Image 2) Let's summarize first this study :

The researchers used medical records from 40 children's hospitals in the US between January 2022 and October 2023. They compared the risk of long-term issues in those with a second COVID-19 infection versus their first infection. Image
Mar 29 6 tweets 3 min read
What a "CLEVER" SARS-COV-2 virus !
... which induced a P812S mutation in a chronically ill individual, that is somewhat less pathogenic but enables the virus to infect a larger population.
biorxiv.org/content/10.110…Image 2) This study looks at how a single mutation, called P812S, in the SARS-CoV-2 virus can have different effects. The P812S mutation was found in a person with a long-term COVID-19 infection. Image
Mar 29 9 tweets 3 min read
INSIDE a COVID-19 crashing WAVE (Nov. 2023 and Mar. 2024, coastal Kenya) 🌊

Fascinating information on variants, symptoms, reinfections, ...
Thanks @siamosolocani
for the study medrxiv.org/content/10.110… 2) The study examines the genomic and clinical epidemiology of a SARS-CoV-2 wave that occurred in coastal Kenya between November 2023 and March 2024. Key findings include:

- The wave was dominated by the XBB.2.3-like and JN.1-like Omicron subvariants ... Image
Mar 28 5 tweets 2 min read
SHOCKING DECLINES in Key IMMUNE CELLS Months AFTER COVID-19 INFECTION !

Let's aim to offer specific data rather than just stating that "COVID-19 weakens the immune system"
onlinelibrary.wiley.com/doi/10.1111/al…Image 2) Here are the significant reductions in multiple key immune cell populations at 10 months after initial COVID-19 infection :

▶️ Total leukocyte (white blood cell) counts were reduced by 12%
▶️ Neutrophil counts were reduced by 11%
▶️ Monocyte counts were reduced by 10% Image
Mar 28 6 tweets 3 min read
How SARS-CoV-2 virus changed over 14 months in a patient with a weak immune system ?

The patient was first infected with the B.1.160 variant, then later got infected with the B.1.1.7 variant. The virus kept changing and evolving inside this patient's body biorxiv.org/content/10.110…Image 2) The virus mutated and recombined, creating new versions of itself. This allowed the virus to adapt and become better suited to the patient's body.

The study found that the virus evolved faster inside this patient compared to how it usually evolves in the general population. Image
Mar 27 7 tweets 3 min read
But what is this ? 🥴
SARS-COV-2-host interactomes ? 🤔

Explainations of astonishing visualisation for laymen 😏
nature.com/articles/s4200…Image 2) This figure shows how the researchers built a 3D model of how SARS-CoV-2 virus proteins interact with human proteins inside cells.

The 3D model that we presented just before, predicts which viral and human proteins will physically bind. Image
Mar 27 6 tweets 3 min read
COVID-19 is anything but mild!

Consider a study involving 1,889 individuals from rural Honduras, examining the changes in their gut microbes over a two-year period due to COVID-19.

The findings are quite astonishing!
biorxiv.org/content/10.110…Image
Image
2) The researchers found that the gut microbes of these people changed a lot during this time.

Most of the changes were linked to COVID-19 infections. People who had COVID-19 had more of certain gut bacteria, like Coprococcus and Dorea. Image
Mar 26 9 tweets 4 min read
SARS-COV-2 INFECTION, LONG COVID and SYNAPSES 🧵

How SARS-CoV-2 Disrupts Brain Synapses Through Abnormal Microglial Response ?
(laymen terms explanations) Image 2) Synapses are the connections between neurons in our brain. They allow neurons to communicate and work together. This communication is crucial for normal brain function and activity. Image
Mar 26 7 tweets 3 min read
SARS-COV-2 3D INFECTION
... for laymen ! 🙋
(with amazing visualizations)

But what is it? What do these colors mean? 👇 biorxiv.org/content/10.110…Image 2) Let me try to explain the figure and the method used in simpler terms.
It shows a cross-section, or a slice, of the lung. In this image, the researchers used a special technique to map out different patterns of gene activity throughout the lung tissue. Image
Mar 25 6 tweets 2 min read
VARIANT LP.8.1
Key findings by Kei Sato @SystemsVirology

**Variant Overview**: LP.8.1 is a descendant of the JN.1 lineage, showcasing mutations in its spike protein which affect its transmission dynamics globally.
contagionlive.com/view/global-sp…Image 2) **Infectivity**:
- LP.8.1 has a slightly higher relative effective reproduction number (Re) than XEC, but lower infectivity in pseudovirus assays compared to JN.1 (67% lower).
- Mutations such as Ser31del and Phe186Leu may increase infectivity, while others ...
Mar 25 4 tweets 2 min read
Let's be cautious as COVID-19 cases drop.

The SARS-CoV-2 virus could exploit times of low case numbers to evolve new strains that might trigger future surges.
(A great study in Nature 💯💥)
nature.com/articles/s4159…Image 2) When the COVID-19 pandemic is in a low epidemic state with fewer reported cases, the virus appears to be using that time to prepare new variants. The study found that as the number of new confirmed cases decreased, the nb and diversity of SARS-CoV-2 variants increased steadily
Mar 25 6 tweets 2 min read
SARS-CoV-2 virus is HERE FOREVER !

The alarming finding of 100% SARS-CoV-2 infection rate in dogs, indicates that the virus has firmly entrenched itself within the canine population, with a zoonotic threat, as dogs could serve as reservoirs for the virus
bmcvetres.biomedcentral.com/articles/10.11…Image 2) The study found that the SARS-CoV-2 virus, which causes COVID-19, has become common and endemic within the dog population in the region studied. Over the 3-year period, the researchers repeatedly detected the virus in the same dogs, indicating it has become established and ... Image
Mar 24 8 tweets 3 min read
SARS-COV-2, the "evil" virus

How Does SARS-CoV-2 Exploit Interactions with T Cells and B Cells to Establish a Persistent Viral Reservoir and Induce an "Acquired Immune Deficiency Syndrome-like" Condition?
Thanks to @RealCheckMarker
for this top study 💥💯
sciencedirect.com/science/articl…Image 2) A key study to understand why SARS-CoV-2 may use T cells and B cells as a reservoir, instead of killing them off like SARS-CoV-1, and the importance of the N protein versus the spike protein in this process. Image
Mar 24 6 tweets 3 min read
WASTEWATER SARS-COV-2 RNA THAILAND

The estimated number of infected people based on the wastewater data was about 1,000 TIMES HIGHER THAN the OFFICIALLY REPORTED COVID-19 CASES for the same areas and time periods.
nature.com/articles/s4159…Image 2) The study analyzed wastewater from 10 Bangkok WWTPs to estimate COVID-19 infections. The estimated infected population was about 1,000 times higher than officially reported cases. Image
Mar 24 6 tweets 3 min read
Uncovering the Intricate Interplay:
How SARS-CoV-2 Infection May Modulate the Risk of Co-Occurrence with Rhinovirus and Seasonal Coronaviruses, Hinting at Underlying Viral Interference Mechanisms in Respiratory Virus Dynamics
journalofinfection.com/article/S0163-…Image 2) The study found that the odds of having a SARS-CoV-2 co-infection with either rhinovirus or seasonal coronavirus were lower compared to having a mono-infection with those other viruses.

This indicates that the presence of SARS-CoV-2 may somehow interfere with or ... Image
Mar 23 7 tweets 3 min read
The Virus That Learned a New Trick: How a Single Change Made It Prefer People

▶️ Virus mutations explained to kids - Example of H5N1 hemagglutinin Image 2) Imagine you have a bunch of dice, and each die represents a different type of flu virus. Some of the dice have pictures of birds on them, and some have pictures of people.

Now, let's say you have a virus that's really good at landing on the bird dice. Image
Mar 23 5 tweets 2 min read
SARS-CoV-2's ALARMING ALLERGEN -LIKE TACTICS :

Uncovering a Potential Immune Evasion Strategy that Could Impact Vaccine Effectiveness
(Preprint version)
preprints.org/manuscript/202…Image 2) The SARS-CoV-2 virus may have special features that allow it to trick the immune system. Some viruses, like HIV and RSV, can trigger an allergic-like response in the body. This causes the immune system to react in a way that helps the virus survive rather than fighting it off Image
Mar 13 10 tweets 4 min read
AVIAN FLU for KIDS
What Happens When Viruses Team Up?

Let’s talk about two interesting friends in the virus world: H5N1 and H3N8. They are both types of avian influenza viruses, which means they can make birds sick. Image 2) Now, what do those numbers mean?
The "H" and "N" in H5N1 and H3N8 are like special codes that tell us something important about each virus. The "H" stands for hemagglutinin, and the number after it (like 5 or 3) tells us which type it is. Image
Mar 6 10 tweets 4 min read
IMAGINE You're a SNEAKY SARS-CoV-2 VIRUS :
How You’d Use Blood Vessels to ATTACK the HUMAN BRAIN, Create Chaos, and Confuse the Brain’s Cleanup Crew!

An Informative EXPLANATION based on 3 recent studies, FOR KIDS and EVERYONE ! Image 2) Imagine Our Body as a Big City:

In this city, blood vessels act like roads, allowing cars (our blood cells) to travel everywhere. Sometimes, bad guys called viruses, like SARS-CoV-2, sneak into this city. Image
Mar 6 6 tweets 3 min read
H5N1 ALARMING ADAPTATIONS:
How Mutations in the Bird Flu Virus are Enabling Spread Between Animals and Posing Grave Pandemic Threat to Humans
(Thanks to @greg_folkers for this new study in Nature)
nature.com/articles/s4146…Image 2) The H5N1 bird flu virus spread quickly along the coast of Chile, infecting wild birds, farm chickens, and sea animals like seals and dolphins.

The virus came from Peru and then moved south through Chile. Importantly, the virus changed in a way that helps it infect and ... Image