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Never be afraid to raise your voice for honesty and truth and compassion against injustice and lying and greed. William Faulkner
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Mar 2 6 tweets 3 min read
Catching COVID-19 in Buildings: Combining Wastewater, Air, and Surface Monitoring !

An amazing study in Nature.
H/t @mryoung151
nature.com/articles/s4137…Image 2) This study looked at different ways to detect COVID-19 in a building. The researchers tested air, surfaces, and wastewater to see which methods could best detect the virus.

They placed air samplers in the lobby of a dorm where students with COVID-19 were isolating. Image
Feb 27 5 tweets 2 min read
Alarming Shift in H5N1 Bird Flu: Longer Neuraminidase Stalks May Boost Transmission Risk

H/t @florian_krammer Thanks @DavidJoffe64
journals.asm.org/doi/10.1128/mb…Image 2) The H5N1 bird flu virus has been spreading rapidly since 2020. An important change is that the neuraminidase (NA) protein on this virus now has a longer "stalk" region.

In the past, most H5N1 viruses had a shorter NA stalk. Image
Feb 24 5 tweets 2 min read
What an UNFORTUNATE CHOICE of WORD it is to REFER to the term “VARIANT” in relation to SARS-CoV-2.

No one would think to call Prince William a "variant" or a mere variation of Queen Elizabeth; he shares the same family and lineage. That's all. Image 2) I wanted to use this analogy to highlight the significant differences in pathogenicity and transmission among the Alpha, Delta, and Omicron variants, as demonstrated by a recent study published in Nature.
nature.com/articles/s4429…Image
Feb 24 6 tweets 3 min read
Can a SYNTHETIC RECEPTOR that BINDS to the SUGAR (Glycans) on the SARS-CoV-2 Spike Protein, PREVENT the VIRUS from INFECTING Human CELLS?

Amazing study 🙏 @DavidJoffe64
…mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…Image 2) Viruses like SARS-CoV-2 have proteins on their surface called spike proteins. These spike proteins help the virus attach to and enter human cells. The spike proteins are heavily coated with sugar molecules called glycans. Image
Feb 23 4 tweets 2 min read
WHEN and WHERE was the H5N1 influenza A virus (genotype D1.1) DISCOVERED ?

A very interesting article from
@LouiseHMoncla @angie_rasmussen @MichaelWorobey @PeacockFlu and colleagues
virological.org/t/timing-and-m…Image 2) The H5N1 influenza A virus (genotype D1.1) was discovered in dairy cattle in Churchill County, Nevada, on January 31, 2025. The detection followed a routine surveillance program, where bulk milk samples were collected from dairy processing plant silos on January 6 and 7, 2025. Image
Feb 23 6 tweets 2 min read
What makes VIRUSES like Herpes, Epstein-Barr, Flu, H1N1, H5N1 and HIV so EFFECTIVE at INFECTING the BRAIN ?

Viruses can infect and damage the brain, leading to conditions like Alzheimer's, Parkinson's, schizophrenia, and depression
link.springer.com/article/10.100… 2) Some Viruses are able to successfully infect the brain for a few key reasons:

▶️ Direct Brain Entry: Some viruses can directly enter the brain through the nose or other pathways, allowing them to directly infect brain cells. Image
Feb 21 5 tweets 2 min read
"N'oubliez jamais"
Never forget ...

The H5N1 is NEUTROPIC and can also READILY REASSORT, or mix its genetic segments, with other influenza viruses
tandfonline.com/doi/full/10.10…Image 2) The H5N1 virus is neurotropic, meaning it can infect the nervous system, causing neurological symptoms like seizures in the infected wild animals. This neurotropism likely contributes to the rapid spread and high mortality observed.
Feb 20 5 tweets 2 min read
Oral Cavity Serves as Long-Term COVID-19 Reservoir with Increased Periodontal and Viral Disease Risk

biorxiv.org/content/10.110…Image 2) The oral cavity serves as a reservoir for viruses like SARS-CoV-2 due to several factors. Firstly, the presence of saliva can harbor viral particles, which may persist even after the acute phase of infection. Image
Feb 20 4 tweets 2 min read
False positive in SARS-COV-2 tests in Roe Deers ? 🤔

The Presence of SARS-CoV-2 in European Roe Deer Populations and the Complex Role of Cross-Reactivity with Bovine Coronaviruses in Serological Testing
biorxiv.org/content/10.110…Image 2) Researchers found a seroprevalence of 2.20% in antibody tests, suggesting some exposure to the virus. However, they noted that cross-reactivity occurs when antibodies made against one virus, like bovine coronavirus, also react to another, such as SARS-CoV-2. Image
Feb 20 6 tweets 3 min read
Bat-Derived Merbecovirus, a "cousin of SARS-CoV-2," Efficiently Binds Human ACE2 Receptor, Raising Alarm About Potential Pandemic Threat

This virus isolated from a bat in China is related to the pathogen that causes Middle east respiratory syndrome
nature.com/articles/d4158…Image 2) Reference :
"Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptor"
Thanks @DavidJoffe64
for the study
cell.com/cell/abstract/…Image
Feb 19 4 tweets 1 min read
Four lessons COVID taught us about the immune system
(A great article in Nature. Thanks @DavidJoffe64)

COVID-19 revealed:

1) T cells, not just antibodies, are crucial for immunity, providing protection even against variants that evade antibodies;
nature.com/articles/d4158…Image 2) The innate immune system's warning signals can spread systemically, activating defenses throughout the body, potentially limiting severity of later SARS-CoV-2 variants;
Feb 18 7 tweets 2 min read
Why do COVID minimizers favor the study conducted by John Ionnadis and colleagues, which reports a COVID-19 case fatality rate (CFR) of 0.31% over a three-year period in Austria? What limitations should we consider when evaluating this study?
sciencedirect.com/science/articl…Image 2) To begin with, here is a concise overview of the study.

This study looked at COVID-19 deaths and infections in Austria from 2020-2023. It found the death rate varied a lot, being highest early on and dropping later. Image
Feb 18 16 tweets 4 min read
Primary CONCERN for the FUTURE : CO-INFECTION
(Mega-thread🧵 with more than 20 studies)

SARS-COV-2 and Staphylococcus aureus, Influenza, Chlamydia pstittaci, Mycobacterium tuberculosis, HIV, Kaposi's Sarcoma Virus, Tocoplasma Gondi, Adenovirus, Valley fever, Dengue, Measles ... Image 2) February 2024
Feb 17 5 tweets 2 min read
AUTOIMMUNITY in Long-COVID

Viruses can sometimes trigger autoimmune reactions, where the body attacks its own tissues. This can happen through molecular mimicry, where viral proteins are similar to the body's own proteins.
sciencedirect.com/science/articl…Image 2) Viruses can also disrupt the normal regulation of the immune system, leading to autoantibodies that attack the body.

Studies show that some COVID-19 patients develop autoantibodies, even before getting sick. Image
Feb 16 4 tweets 1 min read
▶️ Increased DNA damage is observed in COVID-19 patients.
▶️ The extent of DNA lesions correlates with disease severity.
▶️ DNA breaks are induced by SARS-CoV-2 spike proteins.
▶️ Co-morbidities and antiviral drugs also contribute to DNA damage.
sciencedirect.com/science/articl…Image 2) Studies from different countries have found increased DNA damage in the blood cells of COVID-19 patients, especially those with severe illness. The level of DNA damage can predict the outcome of the disease.
Feb 16 5 tweets 2 min read
The Biological Secrets of LONG COVID-19 RECOVERY :
Identifying Key Proteins, Genes, and Hormones that Distinguish Patients Bouncing Back from Long-Lasting Symptoms 💯💥

biorxiv.org/content/10.110…Image 2) Patients recovering from long COVID had higher levels of certain proteins, genes, and hormones compared to those with long COVID. Specifically, they had:

- Lower levels of inflammatory proteins like CXCL9, CSF1, and FGF21 in the blood Image
Feb 15 7 tweets 2 min read
BEYOND ANTIBODIES:
An Approach to Understanding Immune Escape in Evolving Viruses
(Opinion)

In the majority of research, the immune evasion of new variants or strains of SARS-CoV-2, H1N1 or H5N1 is just evaluated by examining the activity of antibodies generated by B cells. Image 2) Testing for immune escape in viruses like SARS-CoV-2, H1N1, and H5N1 is essential for public health, as it reveals how these viruses evade immune responses from prior infections or vaccinations.
Feb 14 5 tweets 2 min read
A brief history of HUMAN INFECTIONS with H5Ny AVIAN INFLUENZA VIRUSES

Avian influenza, or "bird flu," viruses have posed a threat to both poultry and humans for years.
🙏 @DavidJoffe64 for the study
sciencedirect.com/science/articl…Image 2) The H5 subtype, which can have different "N" types, has caused the most human infections.

The first known human case was in 1997 in Hong Kong. Since then, sporadic cases have occurred, mainly in Asia. Image
Feb 14 14 tweets 5 min read
UNDERSTANDING the SPREAD of SARS-COV-2 VARIANTS
🧵mega-thread of 3 studies

"Real-time estimation of immunological responses against emerging SARS-CoV-2 variants"
"Population immunity predicts evolutionary trajectories of SARS-CoV-2"
"Predicting the spread of SARS-CoV-2 variants" Image 2) To summarize these 3 studies, we will focus on the 3 key figures from each study, ensuring a visual component in this overview.
This will be followed by a brief summary of the shared themes across the studies.

Thanks 🙏
Feb 14 4 tweets 2 min read
H5N1. WINDS of CHANGE :

When the wind disperses the H5N1 high-pathogenicity avian influenza airborne virus over distances exceeding 8 kilometers between farms !!!
biorxiv.org/content/10.110…Image
Image
2) This study investigated an H5N1 bird flu outbreak that spread from a duck farm to two nearby chicken farms in the Czech Republic, despite high biosecurity. Genetic analysis showed identical virus strains, suggesting airborne transmission. Image
Feb 13 7 tweets 2 min read
▶️ What is driving the STRONG RESURGENCE of the FLU?
▶️ When can we EXPECT to RETURN to NORMAL patterns of respiratory virus circulation?

A recent key study in Nature sheds light on these two important questions.
nature.com/articles/s4146…Image 2) The researchers found that influenza viruses, especially influenza A strains, were among the last respiratory viruses to reappear after COVID-19 restrictions were lifted. This delay was likely due to differences in factors like immunity duration and virus-virus interactions. Image