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Jul 6 โ€ข 6 tweets โ€ข 3 min read
The HISTAMINE RECEPTOR H1 ACTS as an ALTERNATIVE RECEPTOR for SARS-CoV-2

Great thanks to @mryoung151
for this study ๐Ÿ™
journals.asm.org/doi/10.1128/mbโ€ฆ
Image 2) This study found that the histamine receptor H1 (HRH1) can act as an alternative entry point for the SARS-CoV-2 virus to infect cells, in addition to the main receptor ACE2.

The researchers screened approved drugs and discovered that antihistamine drugs ... Image
Jul 6 โ€ข 4 tweets โ€ข 2 min read
WHAT TREATMENTS WORK AGAINST COVID-19? ๐Ÿ’ฏ๐Ÿ’ฅ๐Ÿ‘

Everything you want to know is here ๐Ÿ‘‡


WHO ARE THEY?
They are a group of PhD researchers, scientists, and individuals dedicated to making a contribution, no matter how small. c19early.org
Image 2) Their research can be found in reputable journals like Science and Nature.
WHAT TREATMENTS DO THEY RECOMMEND?
They cannot provide medical advice but recommend to consult a qualified physician who can give personalized recommendations based on your medical history and ... Image
Jul 6 โ€ข 5 tweets โ€ข 2 min read
23-YEAR ANALYSIS of the STATISTICAL CONTROL CHARTS in EPIDEMIOLOGICAL MONITORING, with a focus on the COVID-19 pandemic.

journals.lww.com/md-journal/fulโ€ฆ
Image 2) Key findings:
- Control chart usage in epidemiology increased significantly during the COVID-19 pandemic, peaking in 2021-2023 (18%, 36%, 41% of applications respectively).
- Commonly monitored variables include influenza, Salmonella, infection rates, as well as COVID-19 ... Image
Jul 6 โ€ข 6 tweets โ€ข 2 min read
WHY the SAME VACCINE DOSE for EVERYONE?

This small study shows that kidney transplant patients can have very different responses to the same vaccines. Some developed protective antibody levels, while others did not, even with the standard vaccine doses.
journals.lww.com/md-journal/fulโ€ฆ
Image 2) The findings suggest we can't just give everyone the same vaccine schedule. Each person's immune system may respond differently. Some may need extra vaccine doses to build up enough antibodies for protection.
Personalized Vaccine Schedules Could Help
Jul 5 โ€ข 4 tweets โ€ข 2 min read
SEARCH TRAFFIC for INFLATABLE PENILE PROSTHESIS increased following the COVID-19 PANDEMIC in the US: a Google Trends analysis

nature.com/articles/s4144โ€ฆ
Image 2) This study analyzed Google Trends data to examine the impact of the COVID-19 pandemic on public interest in inflatable penile prosthesis (IPP) in the US. Prior to the pandemic, there was a consistent upward trend in IPP searches, concentrated in metropolitan areas with ... Image
Jul 5 โ€ข 9 tweets โ€ข 3 min read
SPIKE DEEP MUTATIONAL SCANNING HELPS PREDICT SUCCESS of SARS-CoV-2 CLADES ๐Ÿ’ฏ๐Ÿ‘


A GROUNDBREAKING STUDY conducted by @jbloom_lab and his colleagues sheds light on crucial aspects of the pandemic. nature.com/articles/s4158โ€ฆ
Image 2) The study focuses on two key areas:
โ–ถ๏ธ The impact of Spike mutations, both within and outside the RBD, on immune system evasion, and
โ–ถ๏ธ How these mutations affect individuals with diverse immunological profiles.

This study is in our opinion, one of the most significant
Jul 4 โ€ข 7 tweets โ€ข 3 min read
What if PEPTIDES were KEY ELEMENTS ?
(2nd part) Image 2) In this study,

they investigated the potential neurotoxic effects of SARS-CoV-2 spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial models during brain development. sciencedirect.com/science/articlโ€ฆ
Image
Jul 4 โ€ข 10 tweets โ€ข 4 min read
What if PEPTIDES were KEY ELEMENTS during SARS-COV-2 INFECTION?
(1st part)

Peptides are short chains of amino acids and they play a crucial role in the interaction between SARS-CoV-2, the virus that causes COVID-19, and the human body. Image 2) Peptides are involved in several key processes:
- Viral Entry: SARS-CoV-2 enters human cells by binding to the ACE2 receptor on the surface of the host cells. Peptides derived from the ACE2 receptor can potentially block the interaction between the virus and the receptor, Image
Jul 4 โ€ข 6 tweets โ€ข 3 min read
TISSUE-BASED T CELL ACTIVATION and viral RNA PERSIST for up to 2 YEARS after SARS-CoV-2 INFECTION

(complete summary - Thanks to @DavidJoffe64)

SARS-CoV-2 spike identified in rectosigmoid tissue of individuals with LC months to years after acute infection science.org/doi/10.1126/scโ€ฆ
Image 2) The study used PET imaging with a radiotracer called [18F]F-AraG to detect activated T cells in a cohort of 24 participants at different time points after COVID-19 infection, including those with and without Long COVID symptoms. Image
Jul 4 โ€ข 5 tweets โ€ข 2 min read
DECAY RATES of INFECTIOUS SARS-CoV-2 virus and its RNA in different WATER TYPES (wastewater, lake water, marine water) and at VARYING TEMPERATURES (4ยฐC, 25ยฐC, 37ยฐC).

sciencedirect.com/science/articlโ€ฆ
Image 2) Key findings :
- Infectious SARS-CoV-2 decayed significantly faster than viral RNA across all conditions. At 37ยฐC, no infectious virus was detected after 24 hours.
- Temperature was the primary driver of decay, with higher temperatures accelerating the loss ... Image
Jul 3 โ€ข 5 tweets โ€ข 2 min read
IN-HOSPITAL DELIRIUM After COVID-19 HOSPITALIZATION ๐Ÿ˜จ

jamanetwork.com/journals/jamanโ€ฆ
Image 2) This study examined the association between in-hospital delirium and functional disability as well as cognitive impairment in older adults hospitalized for COVID-19. The researchers followed a cohort of 311 patients aged > 60 for 6 months after their COVID-19 hospitalization. Image
Jul 2 โ€ข 5 tweets โ€ข 2 min read
A very strong increase of a neurodevelopmental DISORDER affecting CHILDREN: 2 times more ADHD during COVID-19 pandemic !

jamanetwork.com/journals/jamanโ€ฆ
Image 2) The study investigated trends in new ADHD diagnoses, prevalence, and medication use in Finland before and during the COVID-19 pandemic. Using nationwide health registers, the researchers found:
- New ADHD diagnoses doubled during the pandemic ... Image
Jul 2 โ€ข 4 tweets โ€ข 2 min read
I LOVE MY HONEY ! ๐Ÿ˜Š

"Honey microbiota, methods for determining the microbiological composition and the antimicrobial effect of honey"
sciencedirect.com/science/articlโ€ฆ
Image 2) Honey is a natural product with antimicrobial, antiviral, and antiparasitic properties. Its microbiota includes beneficial bacteria, yeasts, and molds, as well as potential pathogens. Image
Jul 2 โ€ข 4 tweets โ€ข 2 min read
IMPRINTING of IgA RESPONSES in PREVIOUSLY INFECTED individuals RECEIVING BIVALENT mRNA VACCINES

Not good news at all !
ijidonline.com/article/S1201-โ€ฆ
Image 2) Bivalent mRNA boosters induce lower IgA responses against Omicron variants compared to monovalent boosters, but only in previously infected individuals. The relative fold change in IgA is more skewed towards ancestral spike than variant spike in bivalent-boosted ... Image
Jul 2 โ€ข 6 tweets โ€ข 2 min read
IMPACT of SARS-COV-2 on the LIVER!

Cellular damage and long term complications

Direct COVID-19 liver injury is observed through various histopathological changes. After analyzing several cohorts of liver biopsies, the most common findings associated ... wjgnet.com/1007-9327/fullโ€ฆ
Image 2) ...with SARS-COV-2 hepatic infection were reported and described.
I: Centrilobular areas of confluent necrosis.
II: The inflammatory infiltrate surrounding necrosis showed lymphoplasmacytic infiltrate with histiocytes, few eosinophils, and neutrophils.
Jul 1 โ€ข 4 tweets โ€ข 2 min read
๐™๐™ฌ๐™ค ๐™’๐˜ผ๐™”๐™Ž ๐™Ž๐˜ผ๐™๐™Ž-๐˜พ๐™Š๐™‘-2 ๐™˜๐™–๐™ฃ ๐™ž๐™ฃ๐™›๐™š๐™˜๐™ฉ ๐™˜๐™š๐™ก๐™ก๐™จ :

โ–ถ๏ธ ๐˜พ๐™€๐™‡๐™‡-๐™๐™๐™€๐™€ ๐˜ฐ๐˜ณ
โ–ถ๏ธ ๐˜พ๐™€๐™‡๐™‡-๐™๐™Š-๐˜พ๐™€๐™‡๐™‡ Image 2) SARS-CoV-2 can spread through both cell-free transmission and cell-to-cell transmission (direct contact between infected and uninfected cells) Image
Jun 30 โ€ข 6 tweets โ€ข 2 min read
๐™‡๐™Š๐™‰๐™‚ ๐˜พ๐™Š๐™‘๐™„๐˜ฟ ๐™๐™„๐™Ž๐™†๐™Ž, ๐™๐™€๐™„๐™‰๐™๐™€๐˜พ๐™๐™„๐™Š๐™‰๐™Ž, ๐™‘๐™„๐™๐˜ผ๐™‡ ๐™‹๐™€๐™๐™Ž๐™„๐™Ž๐™๐™€๐™‰๐˜พ๐™€, ๐™Ž๐˜ผ๐™๐™Ž-๐˜พ๐™Š๐™‘-2 ๐™๐™๐˜ผ๐™‚๐™ˆ๐™€๐™‰๐™๐™Ž
(๐˜ˆ ๐˜ฎ๐˜ฆ๐˜จ๐˜ข-๐˜ต๐˜ฉ๐˜ณ๐˜ฆ๐˜ข๐˜ฅ- 20 ๐˜ด๐˜ต๐˜ถ๐˜ฅ๐˜ช๐˜ฆ๐˜ด)


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Jun 30 โ€ข 4 tweets โ€ข 2 min read
๐™‹๐™ง๐™š๐™˜๐™ž๐™จ๐™ž๐™ค๐™ฃ ๐™จ๐™ฎ๐™ข๐™ฅ๐™ฉ๐™ค๐™ข ๐™ฅ๐™๐™š๐™ฃ๐™ค๐™ฉ๐™ฎ๐™ฅ๐™ž๐™ฃ๐™œ ๐™ž๐™™๐™š๐™ฃ๐™ฉ๐™ž๐™›๐™ž๐™š๐™จ ๐™ฅ๐™ง๐™š๐™™๐™ž๐™˜๐™ฉ๐™ค๐™ง๐™จ ๐™ค๐™› ๐™™๐™ž๐™จ๐™ฉ๐™ž๐™ฃ๐™˜๐™ฉ ๐˜พ๐™Š๐™‘๐™„๐˜ฟ-19 ๐™จ๐™š๐™ฆ๐™ช๐™š๐™ก๐™–๐™š

Thanks to @jlerollblues
academic.oup.com/jid/advance-arโ€ฆ
Image 2) Post-COVID conditions (PCC) are challenging to understand and manage due to overlapping symptoms and unclear pathology. This study analyzed 1,988 individuals with post-COVID symptoms and identified three distinct symptom clusters: sensory symptoms, fatigue/difficulty thinking Image
Jun 30 โ€ข 6 tweets โ€ข 3 min read
๐˜ฟ๐™ค๐™ฃ'๐™ฉ ๐™ช๐™ฃ๐™™๐™š๐™ง๐™š๐™จ๐™ฉ๐™ž๐™ข๐™–๐™ฉ๐™š ๐™ซ๐™ž๐™ง๐™ช๐™จ๐™š๐™จ! ๐™๐™๐™š๐™ฎ ๐™˜๐™ค๐™ค๐™ฅ๐™š๐™ง๐™–๐™ฉ๐™š ๐™ฌ๐™ž๐™ฉ๐™ ๐™š๐™–๐™˜๐™ ๐™ค๐™ฉ๐™๐™š๐™ง ๐™ฉ๐™ค ๐™ž๐™ฃ๐™›๐™š๐™˜๐™ฉ ๐™ช๐™จ

๐˜ˆ ๐˜ฌ๐˜ฆ๐˜บ ๐˜ด๐˜ต๐˜ถ๐˜ฅ๐˜บ ๐˜ฃ๐˜บ ๐˜ฐ๐˜ฏ๐˜ฆ ๐˜ฐ๐˜ง ๐˜ฎ๐˜บ "๐˜ฎ๐˜ข๐˜ด๐˜ต๐˜ฆ๐˜ณ๐˜ด" ๐˜ฐ๐˜ฏ ๐˜ต๐˜ฉ๐˜ช๐˜ด ๐˜ด๐˜ถ๐˜ฃ๐˜ซ๐˜ฆ๐˜ค๐˜ต : ๐˜™๐˜ข๐˜ง๐˜ข๐˜ฆ๐˜ญ ๐˜š๐˜ข๐˜ฏ๐˜ซ๐˜ถ๐˜ข๐˜ฏ
spj.science.org/doi/10.34133/2โ€ฆ
Image 2) Viruses can exhibit a range of cooperative and competitive interactions, which often occur in cells co-infected with multiple viral variants.
Some key points of this study :
- Cooperative interactions include genetic complementation, pseudotyping, and ... Image
Jun 30 โ€ข 8 tweets โ€ข 3 min read
๐™‡๐™Š๐™‰๐™‚ ๐˜พ๐™Š๐™‘๐™„๐˜ฟ ๐™๐™„๐™Ž๐™†๐™Ž ๐™–๐™ฃ๐™™ ๐™‘๐™„๐™๐˜ผ๐™‡ ๐™‹๐™€๐™๐™Ž๐™„๐™Ž๐™๐™€๐™‰๐˜พ๐™€
(5๐˜ต๐˜ฉ ๐˜ข๐˜ฏ๐˜ฅ ๐˜ญ๐˜ข๐˜ด๐˜ต ๐˜ฑ๐˜ข๐˜ณ๐˜ต)

"๐™•๐™ค๐™ข๐™—๐™ž๐™š" ๐™ซ๐™ž๐™ง๐™ช๐™จ ๐™›๐™ง๐™–๐™œ๐™ข๐™š๐™ฃ๐™ฉ๐™จ ๐˜ธ๐˜ฉ๐˜ช๐˜ค๐˜ฉ ๐˜ค๐˜ฐ๐˜ฏ๐˜ต๐˜ช๐˜ฏ๐˜ถ๐˜ฆ ๐˜ต๐˜ฐ ๐˜ค๐˜ข๐˜ถ๐˜ด๐˜ฆ ๐˜ช๐˜ฏ๐˜ง๐˜ญ๐˜ข๐˜ฎ๐˜ฎ๐˜ข๐˜ต๐˜ช๐˜ฐ๐˜ฏ ๐˜ข๐˜ง๐˜ต๐˜ฆ๐˜ณ ๐˜ต๐˜ฉ๐˜ฆ ๐˜ท๐˜ช๐˜ณ๐˜ถ๐˜ด ๐˜ช๐˜ด ๐˜ฅ๐˜ฆ๐˜ด๐˜ต๐˜ณ๐˜ฐ๐˜บ๐˜ฆ๐˜ฅ Image 2) According to our opinion, one of the most concerning subjects is the discovery of two possibilities regarding the fragments of the SARS-CoV-2 virus. Firstly, these fragments, generated after the virus is broken down, mimic a crucial component of the body's immune system ... Image
Jun 28 โ€ข 5 tweets โ€ข 2 min read
๐—ฃ๐—ฎ๐˜๐—ต๐—ผ๐—ฝ๐—ต๐˜†๐˜€๐—ถ๐—ผ๐—น๐—ผ๐—ด๐˜† ๐—ผ๐—ณ ๐—Ÿ๐—ผ๐—ป๐—ด ๐—–๐—ข๐—ฉ๐—œ๐——: ๐—ง๐—ต๐—ฒ ๐—–๐—ฒ๐—ป๐˜๐—ฟ๐—ฎ๐—น ๐—ฅ๐—ผ๐—น๐—ฒ ๐—ผ๐—ณ ๐—Ÿ๐—ผ๐˜„-๐—š๐—ฟ๐—ฎ๐—ฑ๐—ฒ ๐—œ๐—ป๐—ณ๐—น๐—ฎ๐—บ๐—บ๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐—ฎ๐—ป๐—ฑ ๐— ๐˜‚๐—น๐˜๐—ถ๐˜€๐˜†๐˜€๐˜๐—ฒ๐—บ ๐—œ๐—ป๐˜ƒ๐—ผ๐—น๐˜ƒ๐—ฒ๐—บ๐—ฒ๐—ป๐˜


The "iceberg model" mdpi.com/1422-0067/25/1โ€ฆ
Image 2) Long COVID (LC) is a complex multisystem disease with diverse symptoms, characterized by low-grade inflammation as a core pathogenetic mechanism. LC lacks clear clinical boundaries and standardized management protocols, complicating its description. Image