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Never be afraid to raise your voice for honesty and truth and compassion against injustice and lying and greed. William Faulkner
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Dec 18 5 tweets 2 min read
POTENTIAL PANDEMIC THREAT:
Single Mutation Switches Bovine Influenza H5N1 to Human Receptors !

science.org/doi/10.1126/sc…Image 2) The bovine influenza H5N1 virus has recently infected some people in the United States. Genetic analysis showed this virus belongs to the H5 clade 2.3.4.4b.
Experiments showed that the original version of this virus binds better to bird-type receptors than human-type receptors Image
Dec 17 5 tweets 2 min read
LARGEST STUDY to date investigating SARS-CoV-2 ANTIBODIES in the CEREBROSPINAL FLUID (CSF) of COVID-19 patients and vaccinated controls.

Thanks to @DavidJoffe64
link.springer.com/article/10.100…Image 2) The main findings are:

▶️ SARS-CoV-2 antibodies can be detected in the CSF after both COVID-19 infection and vaccination, without evidence of intrathecal antibody production. Image
Dec 17 6 tweets 3 min read
A SNEAKY VIRAL PROTEASE:
How SARS-CoV-2 Escapes Cells and Disables Immune Defenses

SARS-CoV-2 has a protease, which is a type of enzyme that can cut and break down other proteins.
H/t @atranscendedman
cell.com/cell-reports/f…Image 2) Normally, this protease would stay inside the infected cells and help the virus replicate.

However, the study found that the SARS-CoV-2 protease, called 3CL, is able to escape the infected cells through special openings called gasdermin pores. Image
Dec 16 4 tweets 2 min read
Researchers studied the STRUCTURE of the H5N1 virus from a human case to UNDERSTAND HOW it CAN INFECT DIFFERENT SPECIES.

biorxiv.org/content/10.110…Image 2) Influenza virus H5N1 has spread from birds to many mammals, including cows in the US. This is concerning because the virus could potentially spread to humans.

They found that the virus's receptor-binding site, which allows it to attach to cells, is already occupied ... Image
Dec 14 4 tweets 2 min read
The DIFFICULTY to PREDICT LONG COVID

Predicting the future prevalence of long COVID (PASC) is challenging due to uncertainty in how COVID-19 spreads. Key factors like the duration and level of active infections and the proportion of people ...
royalsocietypublishing.org/doi/10.1098/rs…Image 2)... who develop PASC after infection, are more important than factors like immunity duration. Even if new variants don't increase PASC risk, their ability to spread and replace older variants can still raise PASC levels over time by changing population immunity. Image
Dec 13 4 tweets 2 min read
SARS-CoV-2 can SPREAD to and REPLICATE in VARIOUS ORGANS, MUTATING DIFFERENTLY in each.

"Multi-Organ Spread and Intra-Host Diversity of SARS-CoV-2 Support Viral Persistence, Adaptation, and a Mechanism That Increases Evolvability"
Thanks to @DavidJoffe64
onlinelibrary.wiley.com/doi/10.1002/jm…Image 2) This study found SARS-CoV-2 virus in most organs of people who died with COVID-19, suggesting it can spread and replicate beyond the lungs. Interestingly, the virus was evolving and mutating differently in various organs within the same person. Image
Dec 13 5 tweets 3 min read
An UNDIAGNOSED and MYSTERIOUS DISEASE is spreading in a remote area of the Democratic Republic of Congo.

Why are we still in the dark about its nature? What exactly is the Kwango province?

Kwango Province is largely defined by its forests. It is regarded as underdeveloped .. Image 2) ...with limited electricity and significant challenges in infrastructure, healthcare, and education. Additionally, the Mobondo militia has engaged in conflicts in the region, contributing to instability and complicating access to certain areas. Image
Dec 13 5 tweets 2 min read
Challenges for developing broad-based mucosal vaccines for respiratory viruses

Developing effective mucosal vaccines for respiratory viruses faces significant hurdles. The respiratory tract's unique features, like mucus and tight junctions, make it difficult to deliver vaccines Image 2) ...and induce long-lasting immunity at the site of viral entry. Safe mucosal adjuvants that can stimulate the right T cell responses are also lacking.
Dec 13 4 tweets 2 min read
NATURAL KILLER (NK) cell research lagging behind T cell research, with 3.57x fewer publications on NK cells than T cells.

This may explain the focus on T cell-based COVID-19 therapies, as NK cell biology was less well-understood, limiting their initial consideration for ... Image 2) ...COVID-19 treatment compared to the more extensively studied T cell responses.

However, in patients with severe COVID-19, the number of NK cells was dramatically reduced, and their activation by target cells was impaired compared to healthy controls. Image
Dec 11 4 tweets 2 min read
POLYGENIC DETERMINANTS OF H5N1 ADAPTATION TO BOVINE CELLS

H5N1 avian influenza virus (lineage 2.3.4.4b, B3.13 genotype) has unexpectedly caused a large outbreak in dairy cattle in North America.

biorxiv.org/content/10.110…Image 2) The study focused on understanding how the internal genomic segments of this virus have adapted to bovine cells. The researchers generated 45 reassortant viruses and found that multiple segments of the B3.13 viruses contribute to their faster replicative fitness ... Image
Dec 11 4 tweets 2 min read
The SARS-COV-2 "HIJACKOME"
explained in a few figures
(Part 1)

The "hijackome" refers to the set of host cell components and processes that the SARS-CoV-2 virus exploits or "hijacks" to enable its own replication and spread within the infected cells. Image 2) The figure 1c shows the levels of key SARS-CoV-2 viral proteins (e.g. nucleocapsid, spike) over the course of infection in the host cells. The Omicron BA.1 and BA.5 variants had slower initial increases in viral protein levels compared to other variants, but ... Image
Dec 5 5 tweets 2 min read
GENETIC FACTORS play a MAJOR ROLE in how the IMMUNE SYSTEM RESPONDS to COVID-19.
biorxiv.org/content/10.110…Image 2) The researchers found thousands of genetic variants that influence gene expression in immune cells, and many of these were specific to COVID-19 patients. They also discovered that the effects of these genetic variants depend on the functional state of the immune cells. Image
Dec 2 4 tweets 2 min read
How LONG can H5N1 REMAIN STABLE in RAW MILK?
Why does the widespread DETECTION of H5N1 in WASTEWATER NOT LEAD to a HIGH NUMBER of HUMAN CASES?

biorxiv.org/content/10.110…Image 2) The study found that H5N1 is remarkably stable in raw milk, with a half-life of 2.1 days at 4°C. This means infectious virus could persist for over a month in refrigerated raw milk from infected cows. Even at room temperature (22°C), the half-life was 0.74 days ... Image
Dec 1 6 tweets 2 min read
UNDERSTANDING the EMERGENCE and SPREAD of NEW VARIANTS

Example of Dispersal history of SARS-CoV-2 variants Alpha, Delta, and Omicron (BA.1) in Spain
pmc.ncbi.nlm.nih.gov/articles/PMC11…Image 2) The dominant factors that contributed to the emergence and spread of new SARS-CoV-2 variants in Spain appear to be:

▶️ Relaxation of control measures: The study links the increased introductions and spread of Delta and Omicron-BA.1 to the "lifting of certain control measures" Image
Nov 27 5 tweets 2 min read
The DANGER THEORY of IMMUNITY revisited
(A fascinating study 💯👍)

This theory proposed by Polly Matzinger in 1994, suggests that the immune system responds primarily to signs of tissue stress or damage rather than just recognizing foreign invaders.
nature.com/articles/s4157…Image 2) This means that for the immune system to react effectively, it needs two things: the ability to recognize harmful substances (antigenicity) and signals that indicate tissue damage (adjuvanticity). Image
Nov 20 5 tweets 2 min read
Recombination among coronaviruses is limited by genetic distance, with SARS-CoV-2 likely acquiring unique traits from closely related sarbecoviruses.

A very interesting study 💯👍
journals.asm.org/doi/10.1128/jv…Image 2) Coronaviruses can exchange genetic material through recombination, but this mainly happens between closely related viruses within the same species. Recombination between distantly related coronaviruses is rare. Image
Nov 20 6 tweets 3 min read
COVID-19 patients show altered immune responses and neuropsychiatric symptoms. SEVERITY CORRELATES with GUT MICROBIOME changes, systemic inflammation, and mental health issues.

medrxiv.org/content/10.110…Image 2) The study examined the connections between gut bacteria, immune responses, and physical/mental health symptoms in hospitalized COVID-19 patients. It found that many patients experienced significant physical problems, as well as high levels of anxiety, depression, and stress. Image
Nov 19 5 tweets 2 min read
Impacts of host factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression

H/t @atranscendedman Thanks to @DavidJoffe64 for the full study
tandfonline.com/doi/full/10.10…Image 2) This review discusses how various factors in the human body can affect a person's risk and severity of COVID-19.
Key points:
- Receptors like ACE2 and neuropilin-1 allow the virus to enter cells. Differences in these receptors due to genetics, age... can impact infection risk Image
Nov 19 7 tweets 2 min read
Why Post-COVID recovery seems faster after an infection with the SARS-CoV-2 Omicron variant ?

This study looked at factors affecting recovery from long-term COVID-19 symptoms, called post-COVID-19 condition (PCC).
link.springer.com/article/10.100…Image 2) In this study, they used data from a large German study.

Key findings:
- Recovery was faster for people infected with Omicron or Delta variants compared to earlier strains. Image
Nov 19 5 tweets 2 min read
SARS-COV-2 POPULATION IMMUNITY: EPITOPES, EPITOPES and EPITOPES !

An epitope is a small part of a molecule (like a protein) that the immune system recognizes and binds to, triggering a response.
journals.plos.org/plospathogens/…Image 2) This study examined how the antibody response targets different parts of the SARS-CoV-2 spike protein, depending on a person's prior infection and vaccination history. The researchers created a panel of mutant spike proteins to map the key epitopes ... Image
Nov 19 4 tweets 2 min read
Time is of the essence: effectiveness of dairy farm control of H5N1 is limited by fast spread

Weekly bulk milk testing for H5N1 is often too late; better surveillance and focus on biosecurity are needed for effective intervention.
buff.ly/3YWGRCyImage 2) Very interesting data/figures

Fig. 1 Epidemic curve of H5N1 at the farm levels Image