Thread by @DrJackKruse

1. NATURE'S MAGNETS ARE IONS EJECTED FROM THE CORE OF STARS that control the biology of your microbiome. This is something you'll never hear from microbiome "experts."

​These atoms are heavier than iron. Cells use those atoms to create other unique magnetic signals, which are helpful in the clock genes in cells as accurate flow meters of entropy.

2. This implies that all biological magnets used in mitochondria and cells come from things that make light. This is axiomatic and critical in showing how physics trumps biochemistry in controlling how life unfolds below the cell level.

Since manganese has a nuclear spin of 5/2 and a nuclear magnetic moment of 3.4687, spectral lines of Mn II show it has a hyperfine structure (HFS). Manganese has one stable isotope with a mass number of 55. The ground electronic configuration of Mn II is 3d5(6S)4s (Sansonetti & Martin 2005). This specific electronic configuration allows cells to create SOD2 (superoxide dismutase 2) from excess oxygen from mtDNA metabolism.

3. It has long been known that phosgene, a deadly war gas and industrial reagent, causes intense oxidative stress, but how it does so remains unclear. Here, we report an accidental discovery: electron spin resonance spectroscopy (ESR) of live fruit flies revealed to researchers in the Turin lab that phosgene exposure results in a distinctive manganese (II) hyperfine spectrum.

The Mn(II) signal correlates with mitochondrial SOD2 expression. Turin's data suggested that phosgene acylates a highly conserved SOD2 active site tyrosine. This prevents the Mn redox cycling between ESR-silent Mn(III) and ESR-active Mn(II) that is required for superoxide dismutation. Turin proposed that mitochondrial SOD2 inactivation is responsible for phosgene toxicity. ESR is a machine that measures magnetochemical species in physical chemistry.

4. It reveals the queerest aspects of Nature that remain hidden from the biologists and biochemists.  Manganese is not a particularly common element on Earth.  It is the 12th most common element in the rocks of Earth.  However, where it is concentrated reveals the quantum biological story of the evolution of prokaryotes and their lives before oxygen filled the ionosphere. Remember, prokaryotes fill your microbiome. It explains why animals encase them in their guts and on their skin just above the circulatory system.

5. The most incredible abundance of manganese is ferromanganese nodules and crusts along the ocean floor. Marine chemical processes and microorganisms (prokaryotes) capture dissolved manganese in seawater, which is precipitated on the ocean floor.  Once captured, the prokaryotes could use the element to create spectra and a bunch of chemical magnets (ROS/RNS) to drive biology using light DIRECTLY from matter.  It should immediately stimulate your neurons to recall that Prokaryotes emit 5000 times more light than eukaryotes.  It would help if you remembered that prokaryotes populated our ocean long before eukaryotes appeared on Earth.  This mechanism is ancient, photonic, and electronic.  It is not holistic! It is not alternative medicine.  

It is native biology, and it reveals that centralized science and medicine are the real alternative versions of events created by the minds of man in his labs.  It is directly related to the organizational plans buried in Nature.

6. Shannon's theory of Information has told us that unusual things make excellent information carriers in computing machines. ROS and RNS production and light spectra are examples of such signals.  The ground electronic configuration of Mn II is 3d5(6S)4s, a superb information carrier with evolutionary severe weight.  Phosgene is a chemical that puts an acetyl group on the aromatic amino acid tyrosine, and this small biochemical change blocks the electronic transition and the flow of information in mitochondria.  It blocks the Mn redox cycling between ESR-silent Mn(III) and ESR-active Mn(II) required for superoxide dismutation.  Many people do not know that ESR silent Mn(lll) is the source of many of the critical evolutionary porphyrins of life.  High spin Mn(lll) has an electronic configuration 3d4(6S)4s.  Nature used the D shell electronic configuration of Mn as her signal for SOD2 production in living creatures.  Let that level of complexity sink in while you still think biochemistry is "the main controller" in your cells.

7. The physical chemistry of the atom of Mn contains the answer.

High spin Mn(III) is the archetypal of such non-Kramers ions.  Mono and polynuclear Mn(all) are of central importance in biological systems that use heme-based proteins like cytochrome c oxidase, catalase, and photosystem II. In contrast, Mn(III) porphyrins phthalocyanines have been used as building blocks in the construction of molecule-based magnets.  This has vast implications for how life operates below the cell level.  Soon you'll learn about that level because it is not in your biology books and not in any medical textbooks.  That is how vital Turin's serendipitous finding was for the Ivory Tower. The Ivory Tower of Science still has no idea what he uncovered.  Some of us already knew biology was driven by changing the electronic configuration of ions using light spectra.

pubs.acs.org/doi/10.1021/ja…

8. Dr. Goobie needs to use his skills to help me. He now needs to understand how nature's decentralized programs operate inside his patients and why he is unable to help them.

9. Nature sells us SANCTUARY from bad ideas and thinking. Growth only happens when you stretch and make yourself uncomfortable. Embrace the suck. I did in neurosurgery.

10. Melanin pigments in mammals are important regulators for color and photochemistry of the evolution of essential functions of human skin, gut, and brain. Melanin is the main 'quencher' of superoxide created in and by the cytochromes of the mitochondria to limit non-visual photoreceptor damage in cytochromes and the rest of the body.  I believe this effect is critical in protection from diseases like Alzheimer's & Parkinson's disease.  See where melanin comes from aromatic amino acids with action spectra in the UV range. POMC and photon traps build it.

The concentration of melanin and its depth distribution is strongly affected by ultraviolet radiation and its absorption.  You must have your skin and eye in the game to activate melanin, and if you are in blue light, you must realize this destroys melanin.  Hence, I say diabetes and PD are both blue-light diseases.

In un-tanned skin/gut/brain, melanin pigments are found only in the basal layer of the epidermis, while in tanned skin, it is distributed throughout the epidermis. In the eye, it is found in the RPE.   So far, mainly the amount of melanin, and not its distribution, has been considered in view of skin photobiology. With an advanced radiative transfer model, investigations have shown how the depth distribution of melanin influences the amount of ultraviolet radiation that reaches living cells in the epidermis and thus can affect folate and B12 levels positively or negatively and affect repair or damage the DNA in the cells. B12 is a photoreceptor in the gut and brain of humans. Few see these connections.