Yesterday we released “The Persistent Dozen.”
It includes 12 papers on SARS-CoV-2 persistence. There are 100s & we are currently sorting through them, but here are 12 interesting ones.
There is no doubt, SC2 & spike protein persist.
#LongCOVID
🧵
longcfoundation.org/post/persisten…
1. Blood Transcriptomic Analyses Reveal Persistent SARS-CoV-2 …
Keys:
- SARS-CoV-2 (SC2) Antisense Indicates Replicating Virus Is Found 65% Of Time In Those With Long COVID
- SC2 Antisense & FYN Together = 93.8% Sensitivity & 91.7% Specificity
thelancet.com/journals/lanmi…
2. Chronic Biopsy Proven Post-COVID Myoendcarditis …
Keys:
- SARS-CoV-2 (SC2) RNA Detected In 85.7% (Out Of 14 Patients)
- SC2 Found Up To 18 Months After Acute Infection
- SC2 RNA Found In Cardiomyocytes, Endothelium, & Macrophages
onlinelibrary.wiley.com/doi/10.1002/cl…
3. (Dogs Detecting Long COVID)
Keys:
- Dogs Were Able To Identify Long COVID Samples In 13 Of 14 (92.86%)
- When Dogs Were Confronted With LC & Negative Control Samples The Dogs Achieved A Mean Sensitivity (For LC) Of 94.4% & A Specificity Of 96.1%
frontiersin.org/journals/medic…
4. Gastrointestinal symptoms & fecal shedding …
Keys:
- SARS-CoV-2 (SC2) RNA Found Up To 10 Months After Acute Infection (Out Of 113 Patients)
- SC2 Fecal RNA Shedding Occurred In 12.7% At 4 Months After COVID Diagnosis & 3.8% At 7 Months
pmc.ncbi.nlm.nih.gov/articles/PMC90…
5. Lingering SARS-CoV-2 …
Keys:
- Median Time For + Group From Acute SC2 Until Surgery Was 274 Days
- Gastric Specimens From 26 (32.5%) Patients And 4 (100%) Cholecystectomy Specimens Showed Positive Cytoplasmic Staining For The Anti-SC2 N Protein
link.springer.com/article/10.100…
6. Measurement of circulating viral antigens …
Keys:
- SC2 P Detectable In 21% Of Samples 4-7 Months After Infection
- SC2 P Was Detectable in 43% Of 378 People With LC Symptoms
- SC2 Antigens In Blood Of Substantial Proportion Up To 14 Months
sciencedirect.com/science/articl…
7. Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation & Viral …
Keys:
- SARS-CoV-2 T Cell Activation Found In Up To 2.5 Years After Acute Infection
- T Cell Activation In Spinal Cord & Gut Wall Associated With Long COVID
Symptoms
pmc.ncbi.nlm.nih.gov/articles/PMC10…
8. Persistence of SARS-CoV-2 in platelets & megakaryocytes …
Keys:
- SARS-CoV-2 (SC2) Persists & Replicates In Megakaryocytes (MKs)
- MKs Then Produce Platlets That Contain SC2
- MK Frequency Is Increased In Long COVID, Suggesting Viral Persistence
croiconference.org/wp-content/upl…
9. Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection
Keys:
- SARS-CoV-2 S1 Protein Found In CD16+ Monocytes In Long COVID Up To 15 Months After Acute SARS-CoV-2 Infection
pmc.ncbi.nlm.nih.gov/articles/PMC87…
10. Post-COVID-19 syndrome. SARS-CoV-2 RNA detection in plasma, stool, and urine in patients with persistent symptoms after COVID-19
Keys:
- SARS-CoV-2 (SC2) Found 45% Of The Time In Plasma Of Those With Persistent Symptoms After Acute SC2
pmc.ncbi.nlm.nih.gov/articles/PMC88…
11. Persistence of spike protein at the skull-meninges-brain axis …
Keys:
- SC2 Spike P Persists In The Skull-Meninges-Brain Axis In COVID-19 Patients
- Spike Protein Is Sufficient To Induce Brain Pathological & Behavioral Changes In Mice
sciencedirect.com/science/articl…
12. SARS-CoV-2 viral persistence in lung alveolar macrophages …
Keys:
- SC2 RNA Persists In 17 Of 25 (68%) Macaques 6 Months After Acute In.
- SC2 Viral Antigens Persist in 20 Of 25 (80%) Macaques 6 Months
- SC2 Viral Replication Capable At 221 Days
nature.com/articles/s4159…
These are 12 of 100s of papers that show, or discuss, SARS-CoV-2 viral persistence, spike protein persistence, or SC2 particle persistence.
There is absolutely no doubt, SARS-CoV-2 persists & those with Long COVID face unique issues that can’t be dealt with via conflation.
3/16/25 is the last day of Long Covid Awareness week, so …
let’s never forget that SARS-CoV-2 persists when demanding better testing, trials, & treatments.
Cure Long COVID!
#CureLongCovidNOW #LongCovidMakesUsOne #LongCovidAwarenessDay #LongCovid #pwLC #ILCAD2025
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