Thread by @DrJackKruse

The Malate-Aspartate shuttle and its role in connecting cytoplasmic and mitochondrial NAD+/NADH pools are linked to sunrise effects on TCA cycle stoichiometry. This connection arises because circadian cues from sunlight can modulate TCA cycle intermediates (like malate), which the shuttle relies on to maintain NAD+/NADH balance across cellular compartments. NAD+ has a 258 nm absorption spectra and NADH is 340nm. LIGHT is a huge part missing in this story.

2. Ionized Hydrogen (H+) in Mitochondria

Proton Jump Conduction (Grotthuss Mechanism): Within mitochondria, H+ ions (protons) are abundant in the matrix. These protons can move rapidly through water via the Grotthuss mechanism, which involves quantum tunneling. This mechanism allows protons to hop through the hydrogen bonding network, effectively creating superconducting proton cables that facilitate rapid communication.

Ionic Plasma Formation: When hydrogen is ionized, it forms an ionic plasma that behaves like a liquid metal. This plasma, enhanced by iodine, enables efficient charge transport within mitochondria and other cellular fluids like cerebrospinal fluid (CSF). The presence of iodine in CSF, for instance, helps form these superconducting proton cables, linking mitochondrial function to environmental signals.

3. Light Excitation of Electrons:

Mitochondria release infrared light, which interacts with the surrounding water to charge separate it into H+ and OH⁻ ions. This light also excites electrons within the electron transport chain (ETC), influencing the redox state and energy transfer efficiency. The interaction of light with water and mitochondria is crucial for sensing environmental changes.

Magnetic and Electric Fields:

Mitochondria, due to their high density of H+ ions and the presence of transition metals in the ETC, generate strong electric and magnetic fields. These fields can interact with environmental electromagnetic forces, such as those from the ionosphere or solar radiation, to modulate mitochondrial function. The paramagnetic nature of oxygen further enhances this interaction, drawing it towards mitochondria.

4. Environmental Sensing Through Water and IodineIodine's Role:

Iodine, concentrated in the thyroid, brain, and gut, plays a critical role in altering the hydrogen bonding network in water. It forms ionic liquids that enhance charge transport, protecting sensitive molecules like DHA from oxidation and facilitating rapid electron and proton movement. This is particularly important in neural synapses and CSF, where environmental signals are processed.

Sensory Systems:

The human body uses water's hydrogen bonding network to sense environmental signals through all five senses. The interaction of light with water in the brain, for example, converts environmental signals into electrical and then light signals, which are transmitted via white matter tracts. This process recapitulates environmental information within mitochondria.

5. Epigenetic and Disease Implications

Epigenetic Switches: Environmental factors, including light and temperature, can alter the hydrogen bonding network, affecting protein folding and epigenetic switches. For instance, changes in iodine levels or light polarization can lead to misfolded proteins and diseases like Multiple Sclerosis or autism, by disrupting the communication between mitochondria and the environment.

Disease States: Excessive light release from mitochondria or improper hydrogen bonding can lead to altered proton signals, affecting cellular communication and leading to disease. Cold thermogenesis, by increasing the magnetic force and condensing water, can restore proper communication by enhancing the hydrogen bonding network.

6. Mitochondria communicate with the environment directly through the hydrogen bonding network in water, which acts as a medium for energy and information transfer. This network is influenced by light, temperature, and the presence of ionized hydrogen and iodine, creating an ionic plasma that facilitates rapid proton and electron movement. The interaction of mitochondria with environmental electromagnetic fields, mediated by water and light, allows for the sensing and processing of external signals, ensuring that cellular processes align with environmental conditions. This complex dance of hydrogen, water, and light is fundamental to life and health, explaining how mitochondria act as environmental sensors within cells.

The MITO is the edge.