James Throt MBBS, MD, PhD, FRCPath Profile picture
Consultant Neuropathologist, UK. I dissect brains for a living. Always backed by science. Using an alias.

Aug 22, 2025, 22 tweets

As a neurologist, I can’t ignore what I’ve been noticing, both professionally and socially.

People are not the same as they were before the pandemic.

The way they communicate, interact, and connect feels… different.

I want to know if you’re feeling this too?

🧵

@monaktrix Large cohort studies, cognitive testing, and neuroimaging show measurable deficits post-covid.

Population level patterns reveal widespread frontal lobe impacts, even if not every individual is formally tested.

@monaktrix The result? Subtle reductions in insight, moral reasoning, and empathy.

Severity & frequency of infection matter, but individual outcomes vary.

@Jo10030676 @artfulhome1 I did elaborate after that tweet you’ve replied to…

@suzy_dalli You truly believe that repeated neurological insult to the frontal executive region would remain asymptomatic forever?

@JulianRLewis To ignore COVID’s neurological impact is like trying to explain rising dementia rates purely as a cultural trend.

Biology and society are intertwined.

Pretending otherwise is denial.

@lcracraft If you believe you’re all infected at the same rate as the general population, then your Covid conscious lifestyle choices etc are a complete waste of time.

@FenixFella @faithfulpolaris But SARS-CoV-2 is different.

It directly infects vascular/neuronal tissue, breaches the blood–brain barrier, and leaves measurable grey matter loss.

Stress may exacerbate, but viral neuropathology is unique & documented.

@SarahIrvine_8 You have completely rewritten history. Egregiously so.

What a completely dishonest account of what actually happened.

Utter hyperbole.

@TeresaRatcliffe Oh, and a Christian. It just gets better and better.

@7ee6an @AspLovePolitics I’m not inventing anything new; I’m connecting dots that are already peer-reviewed. The fact that the public hasn’t internalised these findings is precisely why popularising science is necessary.

The comments here are a cesspit of denial, minimisation, antivax tropes, lockdown hyperbole, evidence dismissal & disinformation

Above all, they show an unwillingness to accept that a virus proven to damage the frontal lobe might explain symptoms of frontal lobe damage

No hope

For the fallacies being spouted about lockdowns, children & their recent developmental/behavioural issues, please read this thread.

It saves me having to address every nonsense reply.

My god, if ever there was proof of cognitive decline in 2025, the comments here provide it.

Actually, this entire thread is unequivocally wrong.

Proof of SARS-CoV-2 damaging the frontal lobe would not lead to presentations of frontal lobe dysfunction.

It’s far more likely to be attributed to smart phones (invented 2007)/social media (2006)/a few months of lockdown

/s

@influenya Also, the surge in aggression, poor impulse control & antisocial behaviour wasn’t apparent immediately post-lockdown in 2021, nor throughout 2022.

These trends have emerged more recently, consistent with the timeline of repeated SARS-CoV-2 infections rather than brief isolation.

@Ester__Island @AspLovePolitics My job isn’t to spoon feed intellectually challenged individuals on Twitter, by the way.

@henrybenedict_X One is reversible performance fluctuation, the other is measurable neurological insult.

Huge difference.

Important clarification: aggression, poor impulse control & antisocial behaviour trending today did not appear immediately post-lockdowns in 2021–22

These changes emerged more recently, consistent w/cumulative neurological impact from repeat infections, not short-term isolation.

@Mallory71148207 Probably appropriate to mention this whilst we’re at it…

@Elizabe49818821 @putxiwhipped4 @influenya Stress alone can’t explain measurable olfactory bulb atrophy, hippocampal shrinkage, or reduced frontal lobe activity.

Those show up consistently in peer-reviewed COVID neuroimaging and autopsy.

@Elizabe49818821 @characternugget Both show frontal-executive damage after COVID.

But of course, I know you’ll pretend you know better than the world’s top journals.

That’s just two major journals. The evidence is there, your ignorance of it doesn’t make it disappear.

@craigthomler @Artfulgiant256 Social bond decay ≠ neuronal injury.

Let’s not conflate feelings with proven neuropathology.

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