Thread by @DrJackKruse

1. Question asked about deuterium exhaust on Chromosome #2

2. ANSWER: Via the blood.  The fact that deuterium is three times high concentration of glucose proves my point that mammals are costly in time and not energy.  Glucose is the energy intermediate for glycolysis.  Deuterium destroys TCA and urea cycling in the matrix when deuterium is in the INJs ruining cristae alignment via the KIE.  Adult RBC's have no mitochondrial because of this relationship.  Child with fetal Hb cannot handle high deuterium states and this is why they can die of SIDS when they are fed or given too much deuterium from any route.

3. Here is the breakdown of those two specific mechanisms:

1. Transport from Mitochondria to Pancreas
Deuterium isn't transported as a free ion (D+) through the blood; that would be inefficient and potentially toxic. Instead, it moves via metabolic water and substrate cycling:

TCA Cycle Clearance: Mitochondria in cells throughout the body produce "metabolic water" as a byproduct of ATP production. If the mitochondria are struggling, they produce water with a higher deuterium-to-protium ratio.

The Glucose/Bicarbonate Shunt: Excess deuterium is often incorporated into organic molecules (like glucose or amino acids) or stays in the plasma as part of the bicarbonate buffer system (HCO−3).

The Pancreatic Pull: The pancreas has an incredibly high metabolic rate and blood flow. It "collects" these deuterated compounds from the circulation to synthesize digestive enzymes and bicarbonate. When the pancreas is functioning optimally, it shunts these deuterium-heavy molecules into the duodenum (the gut) via pancreatic juice, effectively dumping them out of the systemic circulation. The Beta cells should produces close to 2L of bicarbonate a day to clear deuterium assuming the beta cell pancreatic circadian clocks are operational

4. Answer continued

2. The Bicarbonate Paradox
It seems counterintuitive that adding bicarbonate would make the body produce more, but it works through secretin signaling and alkalization:

Raising the "Floor": Exogenous bicarbonate (like baking soda) slightly raises systemic pH and assists the blood’s buffering capacity. This reduces the "acid stress" on the pancreas.

The Secretin Trigger: Pancreatic bicarbonate secretion is primarily controlled by the hormone secretin, which is released when stomach acid enters the duodenum. Exogenous bicarbonate doesn't necessarily suppress this trigger; instead, it provides the "raw materials" (2 and hydration) more easily.

The "Pump" Efficiency:  Moving bicarbonate into the gut is an active, energy-intensive process (using the ductal cells). By providing exogenous bicarbonate, you reduce the metabolic "uphill" climb the pancreas faces to maintain alkalinity, allowing the endogenous "pumps" to work more vigorously rather than burning out trying to maintain a baseline.

5. @threadreaderapp make me a roll.