A 10-year follow-up of the CENTRAL and DIRECT-PLUS lifestyle trials (n=366) in Circulation: despite participants regaining the weight, every 10% reduction in visceral fat during the original intervention was independently associated with a 28% lower long-term risk of type (1/7)
2 diabetes. (2/7)
Waist circumference and visceral and subcutaneous fat reductions were partially preserved at 10 years. Liver and pancreatic fat were not -- they snapped back. (3/7)
But the dividends from visceral fat loss persisted: better insulin resistance scores and lower metabolic syndrome severity. (4/7)
Honest caveat: this is observational follow-up of trial participants, not a fresh RCT. It shows association, not proof of cause -- residual confounding from diet, activity, and adherence is real. (5/7)
The lesson: scale weight is a noisy proxy. Visceral fat is the metabolic root cause -- losing it once may keep paying you back even when the scale climbs.
Full breakdown coming on the Health Longevity Secrets podcast (6/7)youtube.com/@RobertLufkinMD
Source:
#VisceralFat #MetabolicHealth #Type2Diabetes #Longevity #HealthLongevitySecrets (7/7)doi.org/10.1161/CIRCUL…
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