#ChiefResident blog #NoonConference #meded ALS Presenting as Hypercarbic Respiratory Failure imrespdx.com/imrespdx-blog/…
#NoonConference #Meded
One way to think about the elimination of carbon dioxide is:
"won't breath" - CNS
"can't breath" - PNS, respiratory muscles, chest wall, pleura, upper airway
"can't breath enough" - lungs
One way to think about the elimination of carbon dioxide is:
"won't breath" - CNS
"can't breath" - PNS, respiratory muscles, chest wall, pleura, upper airway
"can't breath enough" - lungs
#NoonConference #meded A recent review article highlights that two large trials (EMPOWER, BENEFIT-ALS) and the ALS trial database (PRO-ACT) found that the rate of decline in FVC predicts the liklihood of death. tandfonline.com/doi/full/10.10…
Another recent study showed that twitch trans-diaphragmatic pressure is the most powerful biomarker for mortality; SNIP is an excellent correlate, and a VC within a normal range suggests a good prognosis. Ultimately, no one single test which predicts all ncbi.nlm.nih.gov/pmc/articles/P…
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