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Edgar V. Lerma 🇵🇭

@edgarvlermamd

May 21, 2019 • 10 tweets • 12 min read • Read on X

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Looking forward to #Nephpearls from #37VicenzaCourse 🇮🇹

Renal Functional Reserve
📌 The difference between the stress (peak) GFR achieved by stimulation & baseline GFR
📌 Identifies the capacity of the kidney to compensate/ increase its function in states of demand/ disease
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 karger.com/Article/Pdf/36…

AKI or kidney attack may damage a variable number of nephrons.
In a subject w/ intact RFR, up to 50% of the nephrons can be damaged without any clinical evidence of baseline GFR reduction or increase in creatinine.
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 karger.com/Article/Pdf/36…

Complete or partial recovery (from AKI) of renal function can be determined by the assessment of the RFR
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 karger.com/Article/Pdf/36…

Renal functional reserve testing can identify at-risk individuals for postoperative AKI ca. 2018
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 annalsthoracicsurgery.org/article/S0003-…

@croncoIRRIV

Continuous renal replacement therapy (CRRT): 40 year Anniversary ca. 2017 from @croncoIRRIV
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 ncbi.nlm.nih.gov/pmc/articles/P…

@Kidney_Int

The first international consensus conference on CRRT ca. 2002 from @Kidney_Int
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 kidney-international.org/article/S0085-…

The spectrum of inflammatory molecules
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 cytosorbents.com/products/cyto-…

Adsorption spectrum: in vitro/ in vivo data
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 link.springer.com/article/10.100…

When the gods of AKI meet ...

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More from @edgarvlermamd

Edgar V. Lerma 🇵🇭

@edgarvlermamd

Feb 26, 2022

Advancing Evidence-Based Care in Diabetes and CKD
#ISNWCN 🇲🇾 #Nephpearls

👉 kdigo.org/wp-content/upl…

Holistic approach for improving outcomes in patients with Diabetes and CKD
#ISNWCN 🇲🇾 #Nephpearls

Glucose-lowering agents in Type 2 Diabetes (T2D) and CKD: Indications and dose adjustments
#ISNWCN 🇲🇾 #Nephpearls

Read 9 tweets

Edgar V. Lerma 🇵🇭

@edgarvlermamd

Feb 26, 2022

@goKDIGO

.@goKDIGO Glomerular Diseases Guideline: Reflections on a Decade of Progress with @adrianliew8 @ReichHeather @Dr_KeishaGibson
#ISNWCN 🇲🇾 #Nephpearls

👉 kdigo.org/wp-content/upl…

@goKDIGO

IgA Nephropathy: A 1st step is in treating IgA Nephropathy is assessing "prognosis" based on data available at the time of biopsy

@goKDIGO suggest using the "prediction tool" that was derived from the largest & most geographically diverse cohort to date

#ISNWCN 🇲🇾 #Nephpearls

@goKDIGO

IgA Nephropathy: The @goKDIGO treatment algorithm recommends consideration of use of corticosteroids in patients with "persistent proteinuria >1g/day" if the risk/benefit profile is favorable

📌 A GFR of 30 is considered a threshold for treatment

#ISNWCN 🇲🇾 #Nephpearls

Read 13 tweets

Edgar V. Lerma 🇵🇭

@edgarvlermamd

Feb 23, 2022

@amjtransplant

First clinical-grade porcine 🐖 kidney xenotransplant using a human decedent model ca. 2022 from @amjtransplant #NephJC #Nephpearls

#VisualAbstract by @NamrataYParikh

👉🏼 pubmed.ncbi.nlm.nih.gov/35049121/

@ASNKidney360

Attitudes to Clinical Pig Kidney Xenotransplantation among Medical Providers and Patients ca. 2020 from @ASNKidney360 #Nephpearls

kidney360.asnjournals.org/content/1/7/657

@NEJM

Paving the Path toward Porcine Organs for Transplantation ca. 2017 from @NEJM #NephJC #Nephpearls

nejm.org/doi/full/10.10…

Read 4 tweets

Edgar V. Lerma 🇵🇭

@edgarvlermamd

Jan 30, 2022

Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls

Multiple or metabolically active stones (stones that increase in size/ number w/in a year)

Children

Demographic groups not typically prone to stone formation

Stones other than those containing calcium

@ravineja

Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja #Nephpearls

sciencedirect.com/science/articl…

@CO_Neph_Hype

Neglected analytes in the 24 hour urine: ammonium and sulfate ca. 2021 from @CO_Neph_Hype @ravineja #Nephpearls

👉 pubmed.ncbi.nlm.nih.gov/34798636/

Read 4 tweets

Edgar V. Lerma 🇵🇭

@edgarvlermamd

Jan 26, 2022

@JAMAPediatrics

PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @drM_sudha

jamanetwork.com/journals/jamap…

@Ped_Neph

Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @md_abdulqader83

link.springer.com/article/10.100…

@bmj_latest

PREDNOS: Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome ca. 2019 from @bmj_latest #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @jbda19

pubmed.ncbi.nlm.nih.gov/31156083/

Read 5 tweets

Edgar V. Lerma 🇵🇭

@edgarvlermamd

Nov 17, 2021

@goKDIGO

Clinical Practice Guideline for the Management of Glomerular Diseases ca. 2021 from @goKDIGO #NephJC #Nephpearls
#VisualGraphics by @michaelturk6

Executive Summary pubmed.ncbi.nlm.nih.gov/34556300/
Full Guideline pubmed.ncbi.nlm.nih.gov/34556256/

@neilturn

The spectrum of glomerular diseases from @neilturn #NephJC #Nephpearls

👉 global.oup.com/academic/produ…

Nephrotic range proteinuria does "not always" mean nephrotic syndrome #NephJC #Nephpearls

👉 pubmed.ncbi.nlm.nih.gov/34556256/

Read 4 tweets

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