Thread by @BadgleyLaurence

AN HOLISTIC THEORY OF FIBROMYALGIA - ESCALATING SYMPTOMS: Recent tweets re: #Fibromyalgia expressed ideas that each setback (symptom escalation, operation, injury etc) incited regression of baseline functioning & pain control.

Setbacks are directly related to etiology of #Fibromyalgia, & which I use as a model of chronic #HSD problems in this tweet thread. IMO, etiology is an unstable body tower, d/t loose joints, under repetitive assault by gravity; a soft tissue repetitive stress disorder.

In #Fibromyalgia sufferers, tissues supporting unstable upright body tower evolve chronic spasms experienced as chronic widespread pain (CWP). Loose joints, which incite tilted body tower, begin secondary to innate ligament laxity &/or injury.

As to joint instabilities: In women, genetic variations of ligament tissues are mostly, but not exclusively, etiologic. In men with #Fibromyalgia predominant, but not exclusive, factor is accidental mechanical ligament injury.

CWP leads to reclusiveness (less sun), sedentary habits, lying down, & perhaps non-optimum nutrition. Studies show that as little as 2 weeks of minimal physical efforts foster major loss of muscle mass/tone. Astronauts leave their landing craft unable to stand.

An observed injury preceding #Fibromyalgia (FM) onset is oft convalescence (bed bound) d/t acute illness. Chronic Lyme, Lupus, & Mono (EBV) have been incorrectly implicated as causes of Chronic Fatigue Syndrome (CFS) & FM.

Profound inactivity can lead to generalized profound reduced muscle mass & tone; leading to muscle spasms & CWP. This phenomenon explains onset as well as setbacks that #Fibromyalgia sufferers experience.

After hospitalization/operation/graded exercise uptick/mechanical injury/dislocation etc., natural response is reclined-rest; resulting in etiologic insult of reduced muscle mass. Over time, this dynamic begets increased #Fibromyalgia symptoms.

#Fibromyalgia begets itself.

Invisible & unrecognized forces initiating & perpetuating #Fibromyalgia are joint instabilities & gravity. Over time, lost soft tissue tethering strength intensifies the disorder; knowledge that suggests way to recovery (see below).

Other physiologic disorders contribute to #Fibromyalgia Syndrome: #MCAS & various #dysautonomias (easily explained via impingements of Autonomic Nervous System proximate to subluxing joints; discussed in other 2019 tweet threads).

#MCAS association w. #Fibromyalgia requires other insights. Body stress/assault, beset w. pain & marginal metabolic activity, arouses General Alarm Response (after Hans Selye & Walter Cannon) & hyper-dynamic hormonal/immunologic functions needed for organism survival.

The General Alarm Response (GAR) proceeds in escalating mode (upslope of bell-shaped curve). Over time, if stress/assault persists, hormone & immune systems fatigue (downslope of the GAR bell-shaped curve).

GAR physiologic responses include white blood cell actions (📶cytokines/interleukins) including mast cells (histamine) as inherent part of defense mechanism. Mast cell hyper-activity is a natural response for organism survival.

Take away message here is that chemical efforts (drugs) to abort #MCAS hyper-activity symptoms are worthy, but not curative. As with all disorders, profound healing follows upon correcting primary links in etiologic causal chain.

In cases of #Fibromyalgia, cure of the disorder seems to be natural therapies to reconstitute tissue health & strength. Efforts need to be made to reverse the primary causes within the causal chain:

Pain reduction, soft tissue tone, nutritional optimization, sunlight, restful sleep & mental equanimity must be addressed. Cannabinoids, Ribose, Niacin, Protein, Vit D, Omega oils, Aquatherapy, Walking & Mindfullness Therapies as first efforts.

Go to @cfsunravelled and model the survivors.

This Tweet Thread has been intended as AN HOLISTIC THEORY OF FIBROMYALGIA - ESCALATING SYMPTOMS: Recent tweets re: #Fibromyalgia expressed ideas that each setback (symptom escalation, operation, injury etc) incited regression of baseline functioning & pain control.