AN HOLISTIC THEORY OF FIBROMYALGIA - ESCALATING SYMPTOMS: Recent tweets re: #Fibromyalgia expressed ideas that each setback (symptom escalation, operation, injury etc) incited regression of baseline functioning & pain control.
Setbacks are directly related to etiology of #Fibromyalgia, & which I use as a model of chronic #HSD problems in this tweet thread. IMO, etiology is an unstable body tower, d/t loose joints, under repetitive assault by gravity; a soft tissue repetitive stress disorder.
In #Fibromyalgia sufferers, tissues supporting unstable upright body tower evolve chronic spasms experienced as chronic widespread pain (CWP). Loose joints, which incite tilted body tower, begin secondary to innate ligament laxity &/or injury.
As to joint instabilities: In women, genetic variations of ligament tissues are mostly, but not exclusively, etiologic. In men with #Fibromyalgia predominant, but not exclusive, factor is accidental mechanical ligament injury.
CWP leads to reclusiveness (less sun), sedentary habits, lying down, & perhaps non-optimum nutrition. Studies show that as little as 2 weeks of minimal physical efforts foster major loss of muscle mass/tone. Astronauts leave their landing craft unable to stand.
An observed injury preceding #Fibromyalgia (FM) onset is oft convalescence (bed bound) d/t acute illness. Chronic Lyme, Lupus, & Mono (EBV) have been incorrectly implicated as causes of Chronic Fatigue Syndrome (CFS) & FM.
Profound inactivity can lead to generalized profound reduced muscle mass & tone; leading to muscle spasms & CWP. This phenomenon explains onset as well as setbacks that #Fibromyalgia sufferers experience.
After hospitalization/operation/graded exercise uptick/mechanical injury/dislocation etc., natural response is reclined-rest; resulting in etiologic insult of reduced muscle mass. Over time, this dynamic begets increased #Fibromyalgia symptoms.
Invisible & unrecognized forces initiating & perpetuating #Fibromyalgia are joint instabilities & gravity. Over time, lost soft tissue tethering strength intensifies the disorder; knowledge that suggests way to recovery (see below).
Other physiologic disorders contribute to #Fibromyalgia Syndrome: #MCAS & various #dysautonomias (easily explained via impingements of Autonomic Nervous System proximate to subluxing joints; discussed in other 2019 tweet threads).
#MCAS association w. #Fibromyalgia requires other insights. Body stress/assault, beset w. pain & marginal metabolic activity, arouses General Alarm Response (after Hans Selye & Walter Cannon) & hyper-dynamic hormonal/immunologic functions needed for organism survival.
The General Alarm Response (GAR) proceeds in escalating mode (upslope of bell-shaped curve). Over time, if stress/assault persists, hormone & immune systems fatigue (downslope of the GAR bell-shaped curve).
GAR physiologic responses include white blood cell actions (📶cytokines/interleukins) including mast cells (histamine) as inherent part of defense mechanism. Mast cell hyper-activity is a natural response for organism survival.
Take away message here is that chemical efforts (drugs) to abort #MCAS hyper-activity symptoms are worthy, but not curative. As with all disorders, profound healing follows upon correcting primary links in etiologic causal chain.
In cases of #Fibromyalgia, cure of the disorder seems to be natural therapies to reconstitute tissue health & strength. Efforts need to be made to reverse the primary causes within the causal chain:
Pain reduction, soft tissue tone, nutritional optimization, sunlight, restful sleep & mental equanimity must be addressed. Cannabinoids, Ribose, Niacin, Protein, Vit D, Omega oils, Aquatherapy, Walking & Mindfullness Therapies as first efforts.
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LOOSE JOINTS, HYPERMOBITY? Gravity is at play in these women with tissue variations. When joint are unstable the obvious compensation is “gorilla” muscles to take over lax ligament efforts. A wise Physical Therapist is key. Lots of dedicated exercise also.
LOOSE JOINTS INHERITED (-15% women) is normal. These woman’s have easier births & indigo-smart children. These women are often quite attractive and smart.
ABORIGINAL SOCIETIES
CHERISHED HYPERMOBILE
WOMEN BECAUSE THEY WERE SMART & PROLIFIC BIRTHERS. INTELLIGENCE GENES LIKELY GROUP WITH HYPERMOBILITY GENES & GENES FOR BEAUTY. MEN WANTED FECUND ATTRACTIVE WOMEN SO THEY SELECTED THEM OUT.
COVID-CAUSED decreased blood volume of blood that is too thick might explain orthodtstic hypotension, POTS. Might also explain the wormy blood clots.
COVID-CAUSED diminished total blood volume might evoke sympathetic nervous system activation to prevent hypotension and prevent syncope. Diminished blood volume would be expected to deliver less oxygen to tissues ⏩️ fatigue & exercise intolerance.
TO BE GAY ON NOT, THE QUESTION? In ancient days of the mid last century, the proper medical terminology was “homosexual”. Homo is a Greek prefix for “man” such as used in our species name, homosapiens, I think. Along the way a new adjective/noun, a euphemism, was created, “gay”.
“GAYNESS” might be adverb. I don’t know, grammar not my long suit. In any case, Anthropologist of last century seemed to be of consensus that a fixed ~15% of the population was homosexual as a transcultural genetic characteristic of homosapiens. Indeed, genes direct hormones.
TO BE GAY OR NOT: THE “GREAT H & E DEBATE” (heredity vs. environment) is a dynamic that has ever lent unending entertainment and fascination to the study of the human condition & especially to the world of medical studies.
MCAS IN LONG COVID: is possibly etiologic via biomechanisms known about MCAS, HYPERMOBILITY (HS) & FIBROMYALGIA (FM). Persons with HS & FM commonly suffer MCAS. Reason has been theorized that mast cells reside proximate connective tissue.
MCAS, HS, & FM: hyperflexible connective tissue evokes mast cell degranulation. Reactive substances provoke proximate neural tissues. Some experimental data for this dynamic. It might be that those with long COVID & MCAS expression might have hypermobility (about 15% women).
IC CAUSE DISCOVERED: for years clinicians have been mystified by etiology of IC. Genes, microbes, toxins, & biochemistry have failed to provide insights. IC oft occurs in women who have Hypermobility Syndrome and/or IBS. These circumstances suggest that IC is a dysautonomia.
IC A DYSAUTONOMIA? parasympathetic part of autonomic system stimulates smooth tissues of bladder & bowel to contract/evacuate those organs. Over activity of this neural network is unmeasurable, as yet, in current medical sciences. Absence of evidence is not evidence of absence.
IC CLINICAL DATA: hypermobile women are potentiated for developing pelvic girdle instability from loose sacroiliac joint (SIJ) ligaments & are prone to Mast Cell Activation Syndrome (MCAS). Dr. Afrin’s book explains MCAS. I published case studies of IC remission via SIJ fusion.
IRRITABLE BOWEL SYNDROME: doctors will tell you the cause is “unknown”. This is not true. IBS is commonly found in women either Hypermobility Syndrome. Reason is that these women are prone to pelvic girdle injuries and ligament laxity of one of the sacroiliac joints.
IBS & HYPERMOBILITY SYNDROME: This association well known in medical circles. Some of these women have regular daily frequent loose stools. Some have intermittent episodes of several days of constipation. Another set of these women have alternating constipation and loose stools.
IBS EXPLAINED: reason cause is “unknown” is that anatomical, tissue, and biochemical explanations are unknown and wanting. However, the dysfunction of the bowel suggests the cause is dysfunction of the autonomic nervous system, the parasympathetic and sympathetic.