Thread by @BadgleyLaurence

#FIBROMYALGIA CAUSATION A LINEAR EQUATION? Theory might regard “fibromyalgia” to be a label for a variety of disorders that have simply devolved from patterns of chronic widespread pain. A Twitter Thread....

Do neural pain fiber activities initiate mast cell degranulation that then cause other populations of nerves to activate? Does degranulation occur regionally to generate a specific pattern of tissue disfunction? Does ligament pain arouse mast cell degranulation?

IMO, #MCAS association w. #Fibromyalgia requires other insights. Body stress/assault, beset w. pain & marginal metabolic activity, arouses General Alarm Response (after Hans Selye & Walter Cannon) & hyper-dynamic hormonal/immunologic functions needed for organism survival.

The General Alarm Response (GAR) proceeds in escalating mode (upslope of bell-shaped curve). Over time, if stress/assault persists, hormone & immune systems fatigue (on downslope of GAR bell-shaped curve).

Upslope of bell shaped curve initiates the General Alarm Response (GAR). If the stress (assault) proceeds in an unremitting fashion, then hormone & immune systems are caused to fatigue, which occurs on downslope of the bell-shaped curve.

Immunologic responses include white blood cell “hormones” (📶cytokines & interleukins) including histamine released from mast cell; inherent aspects of the defense mechanism. Hyperactivity of mast cells is one of the natural responses for organism survival.

It makes Darwinian sense to regard that neural pain responses & mast cell degranulation episodes both have survival qualities & potentials; excepting when they cross peak of the General Alarm Response bell shaped curve.

Once peak of bell shaped curve of General Alarm Response is crossed, continuation of injurious forces/stressors act to degrade organism systems beyond repair, into failure & toward death; why holistic methods of system healing are important.

Physiologic mechanisms are intricate, complex & wrought w. myriad neural & biochemical feedback loops; all making linear analyses difficult. Organism survival systems are replete w. redundancy; further complicating understanding & exogenous control.

Medical scientists are renown for developing synthetic chemicals, many with side effects, to control single symptoms resulting from system-wide dysfunctions. True cure of a system-wide dysfunction is another matter.

I have long regarded that cure of a system disorder (not an interloper microbe or toxin cause) is to approach organic systems with elements & energies known nourishing. If cure or system functional benefits occur, then “Cure Proves Cause”.

As to #Fibromyalgia, my model for #HSD system disorders, one must note significant participation of genetic matrix, which is a variant from “normal”. Compensatory environmental means can be used to discount genetic anomalies.

Ligaments tissue flexibility has survival benefit (ease of childbirth), but potentiates organism for mechanical injury. If joints are loose secondary to ligament laxity, certain exercise regimens can induce muscle compensation (see below).

Aboriginals who regularly travelled, hunted, & dragged their camp goods from place to place included women who were muscularly toned, which compensated for loss of connective tissue stability.

They consumed nutrient dense foods (mostly uncooked) absent concentrated glucose. They experienced generous sun. Myriads of ambient discombobulating synthetic chemicals were not ubiquitous & mucking their biochemical systems.

In the #Fibromyalgia arena is a body of evidence for healing. The efforts made by survivors show “Cure Proves Cause”. Those interested need to model the survivors @cfsunravelled.

Generally, #Fibromyalgia rehabilitation efforts should include musculoskeletal reconditioning (Aquatherapy➡️walking ➡️rucking). Nutritional reconstitution includes nutrient dense foods (Mediterranean diet & certain Nutraceuticals).

Other #Fibromyalgia healing efforts include sunlight and detoxification (saunas & sweat lodges ala American Indians). Mindfulness therapies can induce healing brain functions & hormone-friendly stress reduction.

Cannabis provides natural molecules identical to ones already in our bodies (AE-2 & amandamide + others) that balance immune system function via CB2 cellular receptors & regulate pain via CB1 cellular receptors.

Recent studies have shown: Cannabis outperformed Savella, Lyrica, & Cymbalta (FDA drugs for #fibromyalgia). I studied 20 young skateboarders w. #IBS; nearly all used ~1gm of Cannabis hashish concentrate/day to control symptoms.

CONCLUSION: IMO, from learning patients’ stories, healing from #fibromyalgia requires putting enough good things into organism’s systems & keeping enough bad things out. Then, via homeostasis, “Cure Will Prove Cause”.