Andrew Althouse Profile picture
Aug 15, 2019 3 tweets 1 min read Read on X
Front Squat PR at 370 this evening. Little bit of grind...
I’m gonna need new shoes in the next few months, the EVA on my Powerlift 3’s feels like it’s compressing a little.
Been eyeballing the Velaasa Strakes with their solid wood heel. @KatherineNye6, is your discount code still active?

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More from @ADAlthousePhD

Sep 18, 2023
@yudapearl @robertwplatt Suppose we are studying patients with severe aortic stenosis that are planning to undergo transcatheter aortic valve replacement.
@yudapearl @robertwplatt Suppose there are two different "approaches" that may be used for TAVR. We wish to know if one of them is better than the other.
@yudapearl @robertwplatt But, for various reasons (vascular anatomy, frailty, local operational preferences patient preference) not all patients are really proper "candidates" for both approaches.
Read 20 tweets
Mar 31, 2023
@ztownsend @rabois @MaartenvSmeden OK, let me try to help you guys out here. Against my better judgement.

Suppose I want to know if a particular medication is effective in preventing hospitalization of newly diagnosed COVID patients.
@ztownsend @rabois @MaartenvSmeden Suppose that there are 100,000 new cases in a given week, and by some miracle I have a rich data source that includes a) their date of positive test, b) whether they were hospitalized in the next 30 days after the test, and c) whether they received the medication for all 100K.
@ztownsend @rabois @MaartenvSmeden If that’s all detected cases from the population of interest, I have “census” here so I don’t need “sampling” to know “what’s the probability of being hospitalized?” - but can I confidently answer the question “was the medication effective at reducing hospitalization?”
Read 15 tweets
Feb 10, 2023
Time for my annual love letter to @CritCareReviews and why you should consider going if combination of (location, dates, times, personal circumstances, and other considerations) permit
1. The format is like no other conference I've attended. Instead of 12 concurrent sessions , with a bunch of 10 minute talks that allow 1 question at the end, there's one main stage.
2. On that one main stage, we have the chance to go deep into each trial. Each gets a 90-minute block where the team gets 30-45 minutes to present a detailed history and motivation for the study, talk at length about their experience actually doing it, and of course the results.
Read 8 tweets
Jul 14, 2022
Tongue-in-cheek post from @mikejohansenmd, but this is a pedantic point that increasingly bothers me when I see it: researchers wrongly identifying studies as "case-control" studies that are nothing of the sort.
@mikejohansenmd (It doesn't invalidate the work, really, it's just odd to see how many researchers don't seem to understand what a "case-control study" actually is)
@mikejohansenmd A case-control study *starts* with a group of "cases" - people who have the outcome of interest - and then identifies some suitable "controls" - people who are somehow similar to the "cases" but do not have the outcome of interest.
Read 13 tweets
Jul 7, 2022
First, I think it’s important to understand what stratified randomization is meant to do in clinical trials.
What it is meant to do: ensure (roughly) balanced allocation of people with a certain characteristic to the treatment groups.
Read 37 tweets
Mar 3, 2022
@stephensenn @yudapearl @f2harrell @soboleffspaces @SMuellerLab …and a good first step in learning how they are run would be for @yudapearl understand that at no point are people "randomly selected" to participate in trials. So, to that end…
@stephensenn @yudapearl @f2harrell @soboleffspaces @SMuellerLab Hopefully this will serve as a realistic, easy-to-grasp example of how a trial might be done in practice.
@stephensenn @yudapearl @f2harrell @soboleffspaces @SMuellerLab A patient presents to a particular setting (suppose their primary care physician’s office) seeking treatment for their recurrent migraine headaches.
Read 51 tweets

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