1/ Jeez is there any drug worth taking ? WARFARIN: A long-term adverse effect of warfarin therapy is vascular calcification. The proven mechanism is warfarin’s near-shutdown of the body’s vitamin K recycling capacity.
(contd)
(contd)
2/ As the availability of functional (that is, electronically reduced) vitamin K via the K cycle becomes limited, whether from warfarin therapy, from dietary inadequacies, or from other factors, the body progressively is deprived of vitamin K’s carboxylation capacity. (contd)
3/ The VKD proteins OC and MGP are abundant in bone and vessel wall connective tissues, respectively, and are central to calcium homeostasis in these tissues. Vitamin K depletion impairs their physiological carboxylation, which translates into derangement (contd)
4/ of calcium homeostasis (among other adverse effects); hence, the pathological calcification of the blood vessels, is a severe complication of warfarin therapy. (If you're taking statins alongside Warfarin it's a double whammy as Statins inhibit the synthesis of K2, (contd)
5/ the cofactor for matrix Gla-protein activation, which in turn protects arteries from calcification.
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