Blown away by rising star @mwschoen's masterful storytelling of how he is trying to understand and eradicate racial disparities in myeloma treatment and outcomes...
file:///var/folders/mw/0w9f93f97wscrp764dmz0k900000gp/T/com.apple.iChat/Messages/Transfers/IMG_6462.jpeg #ASH19
@mwschoen Dr. Schoen walks us through a hypothesis that renal impairment and racial differences in estimating renal function may impact treatment and outcome: 1) Pts with renal dies less likely to receive lenalidomide.
@mwschoen 2) Black veterans have higher creatinine but better GFR... if clinician only looks at creatinine, may err in understanding pts renal function.
@mwschoen 3) Black patients more likely to be coded as having renal disease by ICD9 codes
@mwschoen 4) Black pts less likely to receive lenalidomide
@mwschoen 5) Summary - results lead to hypothesis that higher rates of diagnosis of renal disease based on erroneous interpretation of Creatinine in black patients may mediate racial disparities in treatment
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I am not burned out. I love what I do. I love my patients and I love my research. I am not quitting my calling. I am being brave enough to be CEO of my own life. @RUBraveEnough 2/
Why? “Alignment between your career & your core values produces satisfaction, a sense of happiness & fulfillment. A misalignment can cause can everything from minor problems to major disruptions.” 3a/
Abs 694: Dr Puiz presents GEM-Claridex trial of Rd vs Clarithromycin-RD. Got to witness Sweet moment at end when her mentor @mvmateos flashed her the “Great job, my protege!” smile we all need to see ❤️
GEM-Clarieex provides another cautionary tale about a myeloma regimen that is more effective but more toxic in older patients #geriheme....
Very inclusive with pts into their 90s. Significantly greater CR, >=VGPR rates. We should celebrate 🎉 right? But....
Abs 268: @HiraSMian presents data on >5700 pts with MM from Canadian registry with some good/some sobering news for #geriheme pts: 1. ASCT use rising 2. 60% of older pts get a novel drug 3. 20% 1-yr mortality 4. 30% of older patients received NO MYELOMA TREATMENT #ASH19
Even with universal coverage, older pts, lower SES or more comorbidities less likely to be treated for myeloma #mmsm#geriheme#ASH19
High 1-yr mortality for older pts with myeloma who don’t receive treatment. We saw similar rate untreated in SEER- Medicare database. #gerihemencbi.nlm.nih.gov/m/pubmed/29429…
Abstract 67: all new patients with blood cancer age >=75 screened for frailty; participants randomized to receive geriatric consultation. Outcomes: feasibility, 1-yr OS, acute care utilization, goals of care discussion. ash.confex.com/ash/2019/webpr…
86% participated in RCT, but some patients worried that geriatric consultation would make them ineligible for treatment. Just heard this same observation from another #geriheme MD on the opposite side of the country just last night! @ROlinMD
@ROlinMD Outcomes: OS not improved (Abel says geriatrics is not magic!) but geriatric consultation did increase documented goals-of-care conversations. #geriheme#gerionc#ASH19