Edgar V. Lerma 🇵🇭 Profile picture
Jan 12, 2020 6 tweets 9 min read Read on X
Not all elevations in serum creatinine portend bad outcomes‼️
#Nephpearls #NephSAP ImageImage
Permissive AKI in the treatment of heart failure ca. 2019 from @Kidney_Int @scoca1 @KidneydrChirag
#Nephpearls #Cardiorenal
👉🏼 kidney-international.org/article/S0085-… ImageImage
We do not yet know whether stopping RAAS blockade in stage 4 or 5 CKD improves outcomes ... await @STOPACEi_trial findings
📌 One of the controversies raised during #KDIGOBPinCKD 🇬🇧 meeting #Nephpearls
👉🏼 kdigo.org/wp-content/upl… Image
Currently, there is uncertainty as to whether the potential improvements in mortality & morbidity brought about by delaying ESKD and dialysis conferred by cessation of ACEi/ ARB off-set any increase in CVD by their omission #Nephpearls
👉🏼 karger.com/Article/Pdf/44… Image
Proposed approach to managing serum creatinine elevations during hypertension management ca. 2020 from @AmJNephrol @KidneydrChirag #Nephpearls
👉🏼 karger.com/Article/Pdf/50… ImageImage
Continuing ACE-I or ARB therapy in patients with declining kidney function may be associated with CV benefit without excessive harm of ESKD (ca. 2020) from @JAMAInternalMed @JAMA_current @meg21212 @alexchangmd @LesleyInker @JoeCoresh #Nephpearls

👉🏼 jamanetwork.com/journals/jamai… ImageImageImageImage

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More from @edgarvlermamd

Feb 26, 2022
Advancing Evidence-Based Care in Diabetes and CKD
#ISNWCN 🇲🇾 #Nephpearls

👉 kdigo.org/wp-content/upl…
Holistic approach for improving outcomes in patients with Diabetes and CKD
#ISNWCN 🇲🇾 #Nephpearls
Glucose-lowering agents in Type 2 Diabetes (T2D) and CKD: Indications and dose adjustments
#ISNWCN 🇲🇾 #Nephpearls
Read 9 tweets
Feb 26, 2022
.@goKDIGO Glomerular Diseases Guideline: Reflections on a Decade of Progress with @adrianliew8 @ReichHeather @Dr_KeishaGibson
#ISNWCN 🇲🇾 #Nephpearls

👉 kdigo.org/wp-content/upl…
IgA Nephropathy: A 1st step is in treating IgA Nephropathy is assessing "prognosis" based on data available at the time of biopsy

@goKDIGO suggest using the "prediction tool" that was derived from the largest & most geographically diverse cohort to date

#ISNWCN 🇲🇾 #Nephpearls
IgA Nephropathy: The @goKDIGO treatment algorithm recommends consideration of use of corticosteroids in patients with "persistent proteinuria >1g/day" if the risk/benefit profile is favorable

📌 A GFR of 30 is considered a threshold for treatment

#ISNWCN 🇲🇾 #Nephpearls
Read 13 tweets
Feb 23, 2022
First clinical-grade porcine 🐖 kidney xenotransplant using a human decedent model ca. 2022 from @amjtransplant #NephJC #Nephpearls

#VisualAbstract by @NamrataYParikh

👉🏼 pubmed.ncbi.nlm.nih.gov/35049121/ Image
Attitudes to Clinical Pig Kidney Xenotransplantation among Medical Providers and Patients ca. 2020 from @ASNKidney360 #Nephpearls

kidney360.asnjournals.org/content/1/7/657 ImageImage
Paving the Path toward Porcine Organs for Transplantation ca. 2017 from @NEJM #NephJC #Nephpearls

nejm.org/doi/full/10.10… ImageImage
Read 4 tweets
Jan 30, 2022
Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls

Multiple or metabolically active stones (stones that increase in size/ number w/in a year)

Children

Demographic groups not typically prone to stone formation

Stones other than those containing calcium ImageImage
Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja #Nephpearls

sciencedirect.com/science/articl… Image
Neglected analytes in the 24 hour urine: ammonium and sulfate ca. 2021 from @CO_Neph_Hype @ravineja #Nephpearls

👉 pubmed.ncbi.nlm.nih.gov/34798636/ ImageImageImageImage
Read 4 tweets
Jan 26, 2022
PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @drM_sudha

jamanetwork.com/journals/jamap…
Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @md_abdulqader83

link.springer.com/article/10.100…
PREDNOS: Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome ca. 2019 from @bmj_latest #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @jbda19

pubmed.ncbi.nlm.nih.gov/31156083/
Read 5 tweets
Nov 17, 2021
Clinical Practice Guideline for the Management of Glomerular Diseases ca. 2021 from @goKDIGO #NephJC #Nephpearls
#VisualGraphics by @michaelturk6

Executive Summary pubmed.ncbi.nlm.nih.gov/34556300/
Full Guideline pubmed.ncbi.nlm.nih.gov/34556256/
The spectrum of glomerular diseases from @neilturn #NephJC #Nephpearls

👉 global.oup.com/academic/produ…
Nephrotic range proteinuria does "not always" mean nephrotic syndrome #NephJC #Nephpearls

👉 pubmed.ncbi.nlm.nih.gov/34556256/
Read 4 tweets

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