New information. >8000 close contacts of reported cases tested for #COVIDｰ19. Most interesting/concerning/comforting result is 34% of close contacts were + for COVID. This is very large fraction of contacts infected- suggests much wider spread. But 1/n.
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…
There is a silver lining. The large numbers of contacts found to be positive were largely without symptoms, or at least not requiring medical attention themselves at enrollment.... 2/3
So, despite a potentially larger fraction of close contacts than we might have currently known of (though the rate is not too surprising), the data reinforces that most will NOT have severe diseases and many will be very mild. Very nice work by the authors! 3/3
In addition - they looked at coinfections. The Most Important part for me in this regard was the lack of any evidence for crossprotective immunity between #COVID19 and other coronaviruses. 3% COVID+ had other Coronas vs only 1% of COVID negs had other Coronas....
The data here points towards trend of excess coinfections with other Coronas among COVID (no causal argument being made here).
Alternatively, this could point to a methodological issue- false pos for seasonal Coronas because of presence of #COVID19 ? Cannot rule out here.
Alternatively, this could point to a methodological issue- false pos for seasonal Coronas because of presence of #COVID19 ? Cannot rule out here.
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