Starting MICU with @HeavnerPharmD this month🥳! Month long series of #OLWLT (1 thing WE learned today😊)
Posterior Reversible Encephalopathy Syndrome(PRES)➡️serious🧠condition characterized by
🩺Hypertension 🤯headache ⚡️seizures & 👀 loss
TACROLIMOUS▶️immunosuppressant
1/
Posterior Reversible Encephalopathy Syndrome(PRES)➡️serious🧠condition characterized by
🩺Hypertension 🤯headache ⚡️seizures & 👀 loss
TACROLIMOUS▶️immunosuppressant
1/
used for GVHD prophylaxis in HSCT⤴️neurotoxicity&⤴️HTN perpetuating the risk of PRES🤯
During an episode of GVHD➡️ tac levels are often ⤴️ to prevent worsening GVHD BUT➡️⤴️inflammation⤴️tac🧠 penetration & risk of PRES😟
🛑Tac can lead to PRES even if levels are THERAPEUTIC🛑
During an episode of GVHD➡️ tac levels are often ⤴️ to prevent worsening GVHD BUT➡️⤴️inflammation⤴️tac🧠 penetration & risk of PRES😟
🛑Tac can lead to PRES even if levels are THERAPEUTIC🛑
Management is complex⚠️
🎯 is to balance risk of GVHD Vd worsening PRES
✅seizures➡️benzos
✅HTN▶️rapidly titratable anti-hypertensives
May PRES-ur luck by🔄 to cyclosporine➡️but risk for PRES still exists😬
Sirolimous/MMF➡️↘️risk of PRES, but efficacy 4️⃣ GVHD is questionable🧐
🎯 is to balance risk of GVHD Vd worsening PRES
✅seizures➡️benzos
✅HTN▶️rapidly titratable anti-hypertensives
May PRES-ur luck by🔄 to cyclosporine➡️but risk for PRES still exists😬
Sirolimous/MMF➡️↘️risk of PRES, but efficacy 4️⃣ GVHD is questionable🧐
Have you ever seen PRES in your practice? How long does it take to resolve? What management strategies have you used? #oncopharm #icu #neurology #pharmicu
@MikeA_42 @Prof_J_NYC @accpimtrprn @HemOnc_ACCP @PharmacyCCEd @TxPharmD @ABC_PharmD @Berninini
@MikeA_42 @Prof_J_NYC @accpimtrprn @HemOnc_ACCP @PharmacyCCEd @TxPharmD @ABC_PharmD @Berninini
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