Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Mar 13, 2020 β€’ 16 tweets β€’ 22 min read β€’ Read on X
Looking forward to #Nephpearls via
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€
πŸ‘‰πŸΌ ajkdblog.org/category/nephm… ImageImage
#NephMadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€
SGLT2i Region
#Nephpearls
ajkdblog.org/2020/03/13/nep… via @AJKDonline
#NephMadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€
Vaccines Region
#Nephpearls
ajkdblog.org/2020/03/13/nep… via @AJKDonline
CREDENCE: Canagliflozin reduces the risk of kidney failure or death due to CV or kidney disease by 30% compared to current standard of care ca. 2019 from @NEJM
#VisualAbstract by @brendonneuen
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€ #Nephpearls
πŸ‘‰πŸΌ nejm.org/doi/pdf/10.105… ImageImage
EMPA-REG: Empagliflozin, CV outcomes and mortality in Type 2 Diabetes ca. 2015 from @NEJM
#VisualAbstract by @kidney_boy
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€ #Nephpearls
πŸ‘‰πŸΌ nejm.org/doi/pdf/10.105… ImageImage
CANVAS: Canagliflozin and CV & Renal events in Type 2 Diabetes ca. 2017 from @NEJM
#VisualAbstract by @kidney_boy
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€ #Nephpearls
πŸ‘‰πŸΌ nejm.org/doi/pdf/10.105… ImageImage
CV and Renal Outcomes With Canagliflozin According to Baseline Kidney Function ca. 2018 from @CircAHA
#VisualAbstract by @brendonneuen
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€ #Nephpearls
πŸ‘‰πŸΌ ahajournals.org/doi/pdf/10.116… ImageImage
Canagliflozin and renal outcomes in type 2 diabetes: results from the CANVAS Program randomised clinical trials ca. 2018 from @TheLancet
#VisualAbstract by @divyaa24
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€ #Nephpearls
πŸ‘‰πŸΌ ncbi.nlm.nih.gov/m/pubmed/29937… Image
Kidney Physiology 101: Tubuloglomerular Feedback ca. 2008 from @JASN_News
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€ #Nephpearls
πŸ‘‰πŸΌ jasn.asnjournals.org/content/jnephr… ImageImage
Indications for and pharmacologic properties of the aporoved (as of May 2019) SGLT2 inhibitors (SGLT2i) from the August 2019 issue of @KidneyNews
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€ #Nephpearls
πŸ‘‰πŸΌ asn-online.org/publications/k… ImageImage
Ongoing Renal and CV Outcome Trials in Type 2 Diabetes from the August 2019 issue of @KidneyNews
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€ #Nephpearls
πŸ‘‰πŸΌ asn-online.org/publications/k… ImageImageImage
Efficacy and Safety of Empagliflozin in Kidney Transplant Recipients With Posttransplant Diabetes Mellitus ca. 2018
#VisualAbstract by @Vernisartan
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€ #Nephpearls
πŸ‘‰πŸΌ care.diabetesjournals.org/content/early/… ImageImage
#NephMadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€
HD Access Region
#Nephpearls
ajkdblog.org/2020/03/13/nep… via @AJKDonline
Patient selection, education and cannulation of percutaneous arteriovenous fistulae (pAVF) being presented by @wasse_m
#VascularAccessPearls #Nephpearls
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€
πŸ‘‰πŸΌ cdn.ymaws.com/www.asdin.org/… ImageImageImageImage
Dapagliflozin And Prevention of Adverse outcomes in Chronic Kidney Disease (DAPA-CKD) Phase III trial in patients with CKD stopped early based on overwhelming efficacy‼️
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€ #Nephpearls
πŸ‘‰πŸΌ Rationale and protocol academic.oup.com/ndt/article/35… ImageImage
Dapagliflozin was effective at reducing cardiovascular morbidity and mortality in patients with heart failure and reduced ejection fraction independent of diabetes status ca. 2020 from @JAMA_current
#Nephmadness 2οΈβƒ£πŸ€2οΈβƒ£πŸ€ #Nephpearls
πŸ‘‰πŸΌ jamanetwork.com/journals/jama/… ImageImageImage

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More from @edgarvlermamd

Feb 26, 2022
Advancing Evidence-Based Care in Diabetes and CKD
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls

πŸ‘‰ kdigo.org/wp-content/upl…
Holistic approach for improving outcomes in patients with Diabetes and CKD
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
Glucose-lowering agents in Type 2 Diabetes (T2D) and CKD: Indications and dose adjustments
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
Read 9 tweets
Feb 26, 2022
.@goKDIGO Glomerular Diseases Guideline: Reflections on a Decade of Progress with @adrianliew8 @ReichHeather @Dr_KeishaGibson
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls

πŸ‘‰ kdigo.org/wp-content/upl…
IgA Nephropathy: A 1st step is in treating IgA Nephropathy is assessing "prognosis" based on data available at the time of biopsy

@goKDIGO suggest using the "prediction tool" that was derived from the largest & most geographically diverse cohort to date

#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
IgA Nephropathy: The @goKDIGO treatment algorithm recommends consideration of use of corticosteroids in patients with "persistent proteinuria >1g/day" if the risk/benefit profile is favorable

πŸ“Œ A GFR of 30 is considered a threshold for treatment

#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
Read 13 tweets
Feb 23, 2022
First clinical-grade porcine πŸ– kidney xenotransplant using a human decedent model ca. 2022 from @amjtransplant #NephJC #Nephpearls

#VisualAbstract by @NamrataYParikh

πŸ‘‰πŸΌ pubmed.ncbi.nlm.nih.gov/35049121/ Image
Attitudes to Clinical Pig Kidney Xenotransplantation among Medical Providers and Patients ca. 2020 from @ASNKidney360 #Nephpearls

kidney360.asnjournals.org/content/1/7/657 ImageImage
Paving the Path toward Porcine Organs for Transplantation ca. 2017 from @NEJM #NephJC #Nephpearls

nejm.org/doi/full/10.10… ImageImage
Read 4 tweets
Jan 30, 2022
Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls

Multiple or metabolically active stones (stones that increase in size/ number w/in a year)

Children

Demographic groups not typically prone to stone formation

Stones other than those containing calcium ImageImage
Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja #Nephpearls

sciencedirect.com/science/articl… Image
Neglected analytes in the 24 hour urine: ammonium and sulfate ca. 2021 from @CO_Neph_Hype @ravineja #Nephpearls

πŸ‘‰ pubmed.ncbi.nlm.nih.gov/34798636/ ImageImageImageImage
Read 4 tweets
Jan 26, 2022
PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @drM_sudha

jamanetwork.com/journals/jamap…
Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @md_abdulqader83

link.springer.com/article/10.100…
PREDNOS: Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome ca. 2019 from @bmj_latest #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @jbda19

pubmed.ncbi.nlm.nih.gov/31156083/
Read 5 tweets
Nov 17, 2021
Clinical Practice Guideline for the Management of Glomerular Diseases ca. 2021 from @goKDIGO #NephJC #Nephpearls
#VisualGraphics by @michaelturk6

Executive Summary pubmed.ncbi.nlm.nih.gov/34556300/
Full Guideline pubmed.ncbi.nlm.nih.gov/34556256/
The spectrum of glomerular diseases from @neilturn #NephJC #Nephpearls

πŸ‘‰ global.oup.com/academic/produ…
Nephrotic range proteinuria does "not always" mean nephrotic syndrome #NephJC #Nephpearls

πŸ‘‰ pubmed.ncbi.nlm.nih.gov/34556256/
Read 4 tweets

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