Dapagliflozin And Prevention of Adverse outcomes in Chronic Kidney Disease (DAPA-CKD) Phase III trial in patients with CKD stopped early based on overwhelming efficacyβΌοΈ #Nephmadness 2οΈβ£π2οΈβ£π #Nephpearls
ππΌ Rationale and protocol academic.oup.com/ndt/article/35β¦
Dapagliflozin was effective at reducing cardiovascular morbidity and mortality in patients with heart failure and reduced ejection fraction independent of diabetes status ca. 2020 from @JAMA_current #Nephmadness 2οΈβ£π2οΈβ£π #Nephpearls
ππΌ jamanetwork.com/journals/jama/β¦
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IgA Nephropathy: The @goKDIGO treatment algorithm recommends consideration of use of corticosteroids in patients with "persistent proteinuria >1g/day" if the risk/benefit profile is favorable
π A GFR of 30 is considered a threshold for treatment
Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls
Multiple or metabolically active stones (stones that increase in size/ number w/in a year)
Children
Demographic groups not typically prone to stone formation
Stones other than those containing calcium
Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja#Nephpearls
PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics#NephJC#IPNAJC#Nephpearls
Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph#NephJC#IPNAJC#Nephpearls
PREDNOS: Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome ca. 2019 from @bmj_latest#NephJC#IPNAJC#Nephpearls