Ashley & Brooke Barlow PharmD Profile picture
Mar 16, 2020 13 tweets 7 min read Read on X
Tis the season to shape those research projects into a publication 📖

Stuck in writing 🤷🏻‍♀️ and not sure where to go? 🤔

See the Top 8 Tips for Success in Creating Your Manuscript 📝 below!

Who else to teach us residents in need than the one and only @brentnreed 👏🏻
#twitterx
Tip #1 ☝️ things ☝️ just like sports, the first thing to success is building a strong team 💪

Determing authorship is one of the most important to ensure expectations from each player are clear from the start. 🎖

Authorship Guidance by ICMJE icmje.org/recommendation…
Tip #2️⃣ Set a REALISTIC timeline ⏰

Defining a timeline with 🏔milestones, and scheduling 📝 in ⏰ for revisions and time for editor feedback is essential to stay on track 🏃🏼‍♀️

🔑 tip by @brentnreed don’t forget to schedule in time to encorporate editor feedback!
Tip#3️⃣ Determine a list of potential journals

Things to 🤔 about 📖
1. ✅ JANE criteria to see if similar 📓 was published recently?
2. Target 🎯 audience
3. Scope of the 📓
4. Impact factor
@brentnreed suggests shooting one step higher than your intended journal 1/2
& do NOT be discouraged if you get rejected! 🙅

Shooting for the 🌟 with the journal (or one step higher than anticipated) can allow you to get high quality insightful feedback from the reviewers 👩🏻‍💻

Ensuring you encorporate that feedback and perseverance is 🔑
Tip#4️⃣ Develop a concept map 🗺 to help you structure your article 📝

Concept maps to assist w/ structure your 📝 & determine key concepts YOU want to bring out in the article and further help you define what has not been addressed in the current literature
Keeps you on 🎯 !
Tip#5️⃣ BE SURE TO ✅JOURNAL REQUIREMENTS PRIOR TO SUBMISSION!

Can be one of the most ⏰ consuming aspects of the review process if not previously reviewed.

👀 into ALL req (figures, tables, word count) for your article prior to submission to ease the writing & review process!
Tip #6️⃣ Clearly distinguish btwn methods results & discussion ☝️

➡️Methods can be written b4 the research is done! Just describes WHAT ur doing in the research, do not change this unless any major revisions were made during the study (ex. include or exclude pts based on ADR)1/2
Tip6️⃣ cont.

Results: just the facts & figures, do not analyze the data quite yet!

Discussion: here is where you can dive 🏄‍♀️ into discussing the 🔑 findings of your study in relation to current literature. Don’t forget to highlight strengths 👍 & limitations 👎🏻 of the study!
Tip #7️⃣ THIS ONE CHANGED OUR LIVES and will save you so much time and effort 😭 !

Use a reference manager 🖥 such as Zotero or Mendeley to ease the citation process!

So much time and effort saved! 💰
Tip #8️⃣ Put on your thickest skin

We have all had those tough reviewers, and that’s ok we only learn from the feedback we receive! When it comes to a “challenging” reviewer- put on your thickest skin and be sure to politely & respectfully respond to all comments!
Just our final thought 💭 Have FUN!

Easier said than done but...Writing manuscripts IS DIFFICULT, but SO worth the effort!!

So each step🚶‍♀️along the way➡️give your self a pat on the back & reflect on what went well? what didn’t? Adjust accordingly!

Best of luck! 👏🏻

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More from @theABofPharmaC

Jan 7, 2022
Time ⏰ for Part #2 of the Tweetorial 🧵 on the DDI btwn PHT & VPA with a focus on drug metabolism 💊🔄

If you haven’t seen it yet - check out Part 1 by @JimmySuhMD on the albumin interaction btwn PHT & VPA
 
However, that’s only half of the story!⚠️
 
1/n First, let’s discuss basics on phases of drug metabolism 🔄
 
Phase I: Oxidation (ex. CYP450 enzymes)
 
Phase II: Conjugation (ex. Glucuronidation)
 
🎯 Goal 👉🏻 covert drug to an active (pro-drug) or inactive metabolite and ⤴️ solubility ➕ ⤴️drug elimination via urine/bile
2/n What are the key 🔑 metabolic pathways for VPA?

There’s 3️⃣ big ones
 
Phase1️⃣ (~10%)
➢ Substrate of CYP2A6, CYP2B6, CYP2C9
➢ *4-ene metabolite▶️ hepatotoxic ⚠️
 
Phase2️⃣ (~30 – 50%)
➢ Conjugation via glucuronosyltransferase
 
Other▶️Mitochondrial β-oxidation (~40%)
Read 12 tweets
Nov 30, 2021
A #MedTwitter🧵on the frequently obtained, but ever mysterious🕵️‍♀️ Procalcitonin (PCT) 🦠

💡 What is it?
💡 Where does it come from?
💡 What factors/comorbid conditions may impact PCT?

#IDTwitter #TwitteRx
1/n First, let’s discuss the normal, physiologic role of PCT 🧬

✨116 chain amino acid
✨Neuroendocrine hormone
✨Produced by thyroid C-cells
✨Enzymatically cleaved to calcitonin
✨ Regulate Ca+2 & PO4- homeostasis

DOI 10.1093/ajhp/zxaa089

@AJHPOfficial @SESmithPharmD Image
2/n Why/How does PCT ⤴️ in bacterial infections?

✨Nonendocrine tissues (adipocytes, spleen, pancreas, etc) produce PCT but LACK 🛑 enzymes to cleave to calcitonin

✨Stimulus for non-thyroid PCT production include
1️⃣LPS/bacterial toxins ⚠️
2️⃣Cytokines (IL6, TNFa, ILb) Image
Read 9 tweets
Sep 21, 2021
Let’s talk CSF 🧠 💦

☝️ What is it & why is it important?
✌️ Key considerations in CSF sampling 🧪 & analysis 🧐 for suspected infection 🦠

A #NeuroTwitter 🧵 inspired by bedside rounds with attending @BuslKatharina & NCC team👏🏻
So to start, what is CSF? 🤔

CSF▶️clear, sterile fluid secreted by choroid plexus 💦 in the ventricles ➡️circulates throughout the subarachnoid space🧠 & spinal canal🦴

⭐️Function▶️ protective barrier 🛡 provides nutrients 🍎& facilitates removal toxins/metabolic byproducts⚠️
Now, let’s discuss🖐key pearls when analyzing CSF🧐for poss infection🦠

1️⃣Consider the source!

Obtained from a…
▶️“Closed”system, ie LP💉?
▶️“Open”system, ie EVD🧠?

⚠️Interpret CSF💦from “open”sys w/caution▶️blood🩸& inflammation🔥from underlying condition are often present
Read 8 tweets
Aug 20, 2021
Now that the salty🧂debate on the TYPE of fluid to use in the ICU has largely been solved, how about the RATE of IVF? 🤔

Back to the BaSICS💦

✅The Balanced Solutions in Intensive Care Study📖 (BaSICS) ▶️compared 333mL/hr vs 999 mL/h

Does IVF rate impact 90-day mortality? 🤔
💡 10, 520 ICU pts randomized 🏥

Fluid volume:

1162 mL in the SLOW infusion group 💦
vs. 1252 mL in the FASTer group

🛑NO difference in☝️ outcome: 90-day mortality (HR 1.03, CI, 0.96-1.11)

🛑No difference in✌️outcomes: RRT, AKI, ventilator free days, ICU/hospital LOS
Notably, when reviewing this study, the baseline characteristics are a key 🔑 consideration

< 5% of the cohort in both groups had sepsis (⬇️ the generalizability in this population) 🦠

Patients with AKI or ESRD were excluded from the trial 💡
Read 5 tweets
May 27, 2021
Alert 🎙Pharmacy Grand Rounds Thread Ahead! 🚨

Last week I had one of my final presentations of the year! With a catchy title😉

Urine for an Update! Updates in the management of metastatic urothelial cancer

Hold your bladders, this is an extensive update! 😂
#oncopharm Image
Bladder cancer can be divided into two ✌️subtypes:
1) Non-muscle invasive: encompasses in-situ and localized disease➡️5-yr OS >70%

2) Muscle invasive: encompasses regional or metastatic disease➡️5-yr OS dismal especially for metastatic disease 😔 Image
Cisplatin=SOC
50% of pts w are ineligible due to older age👵🏻, poor PS, ⬇️ renal function, ⬇️hearing, neuropathy, heart failure 🫀& other comorbities that ⬆️ risk of ⚠️

Carboplatin yields inferior responses➡️NOT 🙅🏻‍♀️ an equal alternative due to ⬇️ OS😢➡️pt left w/minimal tx options Image
Read 12 tweets
Apr 26, 2021
What medications 💊 are should be avoided 🛑 or used with caution ⚠️ in patients with Myasthenia Gravis? 🤔

See 👀 the thread 🧵below⤵️ that summarizes an amazing grand rounds presentation by @UKPharmRes PGY1 @AliW_PharmD on key 🔑 medication considerations in MG
1️⃣Antibiotics to avoid or use w/caution🦠 💊

🛑FQs = FDA BBW for ⤴️ risk of MG crisis ➡️ avoid use if possible
⚠️ Macrolides ⤴️ rate of MG crisis (case reports)
⚠️ AG linked to ⤴️ ICU acquired weakness & exacerbate ‼️ MG crisis
📝Risk⬆️ w/neomycin vs. tobramycin & amikacin
Antibiotics considered to be SAFE alternatives to the above include

✅Beta-lactams
✅Tetracyclines
✅Linezolid
✅Bactrim

Ex. In an MG patient who presents 🏥 w/CAP 🫁 ➡️ choose ceftriaxone + doxycycline✅ OVER ceftriaxone + azithromycin🛑
Read 7 tweets

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