Thread by @ChiragNepal

Our new work showing "Ancestrally duplicated conserved noncoding element suggests dual regulatory roles of HOTAIR in cis and trans" is out in @iScience_CP cc @UCPHAndersenLab @ferencmueller @BorisLenhard @pundhir_sachin @GroupLenhard @LabMueller 1/N

cell.com/iscience/fullt…

Two conserved noncoding elements (CNEs) overlap HOTAIR and its paralog on HOXD cluster. 2/N

Paralogous CNEs are embedded in mature noncoding transcripts. #ENCODE #GTEx #FANTOM5

Transcribed CNEs with co-evolved complementarity suggest hybridization-based function

Bidirectional transcriptional around HOTAIR CNE 5/N

CNEs are positively coregulated with cis HOX genes but negatively with trans cluster. #GTEx #FANTOM5 #TCGA 6/N

The paper was on @biorxivpreprint
for a while. biorxiv.org/content/10.110… Additional experiments/analysis were added. I hope you will find it interesting. 7/7

Let's try @threadreaderapp "unroll"