Just read 2012 review @NatureRevGenetpubmed.ncbi.nlm.nih.gov/22641018/
DNA methylation has instructive role in initiating or reinforcing silencing ?? Open question !! #NotDNAmExpert, my take, DNAm reinforces silencing. Please share your thoughts.
#DNAm of the Hprt gene on the inactive X chromosome occurred after the chromosome had been inactivated. In other words, #DNAm appeared to serve as a ‘lock’ to reinforce a previously silenced state of X-linked genes. @CellCellPresspubmed.ncbi.nlm.nih.gov/3791414/