Chirag Nepal Profile picture
#Father #Husband #Freeletics #ComputationalBiologist #RNA #Transcription #CancerOmics #OpinionsAreOwn #RTnotanEndorsement #AssistantProfessor
May 13, 2021 7 tweets 5 min read
Just read 2012 review @NatureRevGenet pubmed.ncbi.nlm.nih.gov/22641018/
DNA methylation has instructive role in initiating or reinforcing silencing ?? Open question !!
#NotDNAmExpert, my take, DNAm reinforces silencing. Please share your thoughts. #DNAm of the Hprt gene on the inactive X chromosome occurred after the chromosome had been inactivated. In other words, #DNAm appeared to serve as a ‘lock’ to reinforce a previously silenced state of X-linked genes. @CellCellPress pubmed.ncbi.nlm.nih.gov/3791414/
Mar 27, 2020 8 tweets 6 min read
Our new work showing "Ancestrally duplicated conserved noncoding element suggests dual regulatory roles of HOTAIR in cis and trans" is out in @iScience_CP cc @UCPHAndersenLab @ferencmueller @BorisLenhard @pundhir_sachin @GroupLenhard @LabMueller 1/N

cell.com/iscience/fullt… Two conserved noncoding elements (CNEs) overlap HOTAIR and its paralog on HOXD cluster. 2/N Image