My mother, @SandraHBrenner2, wrote this reflection to be read at #seder. Please share this with attribution
2020, The Night Before
Envisioning this life threatening
invisible invasion now as if it were
another terrible plague of Egypt
passing over a too narrow place,
/1
We, together apart, experience
trauma along with our forebears in
this disorienting, dreadful darkness,
meanspirited realms of selfishness
& senseless violence, driven by
magical thinking pharaohs who play
power games disturbing the delicate
balance of universal law & order,
/2
& bring on pestilence & suffering.
We ask our four questions and do our
best to conceive of the inconceivable
in the retelling of our birth story while
waiting for our honored guest, Elijah,
who will herald the early morning light.
Sandra H. Brenner
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today @davidasinclair is telling the world that he has achieved age reversal with chemical cocktails
he submitted the paper on June 30 & it was accepted on July 4 by a journal of which he is coeditor-in-chief
paper was sent to me 3 days ago by a reporter for comment
reporter was told it is a "groundbreaking study" & "the first chemical approach to reprogram cells to a younger state"
reason WSJ didn't cover that paper is that ppl have been reporting chemical compounds that drive conversion of cells to induced pluripotency for the last 10-15 years
all of the compounds in today's paper were previously reported by others, mostly in 2013
there's a peer review failure today doi.org/10.1016/j.cell… in which an individual with 59 collaborators claims to have tested the information theory of aging
he did not test the information theory of aging
the claim is that he induced dsDNA breaks that are easily repaired, don't cause a DNA damage response or mutagenesis or cell death--only an epigenetic change
he knows this is not true because his co-first author & he published this paper in dec '21
there are a few issues being addressed here. let’s start w safety
human placebo controlled trials have never shown adverse events attributable to Niagen. note that LDL-C is raised in humans w Basis & pterostilbene alone
the class of compounds to which NR belongs is vitamin B3
there are decades of human data on these molecules showing human safety. niacin is unique in causing flushing but nicotinamide was tested in large Australian skin cancer and was shown to be cancer-preventative in ppl
there’s a hierarchy of evidence w human RCTs (and meta-analysis of RCTs) on the top. human case reports & good quality rodent studies are lower. cell studies are lower. poorly conducted rodent and/or poorly conducted cell studies are garbage in/garbage out