A lioness of the Iowa City community emailed this morning to what would have been her seder invitation list:
"With Passover just around the corner, I turned to one of my most trusted doctors, Dr. Seuss. The good doctor (of blessed memory) gave me these words to share /1
on social distancing during Passover.
'I do not want you in my house.
I do not want you or your spouse.
I do not wish to eat with you
At Seder one or Seder two!
Don't get me wrong,
I think you're nice.
Doctor Fauci
Gave out this advice, /2
"Ten Plagues are enough,
You don't need one more.
Turn away Elijah, the prophet,
If he shows up at your front door."
This year's only guests:
Father, mother, son, neighbor.
NEXT YEAR in Jerusalem,
We will say to each other. /3
From now on at each seder,
This story we'll tell,
Of how God saved his people
With a squirt of Purell!' /4
The email closed with her saying, "I am making gefilte fish and chopped liver and I would love to share it with you if you would like some. Just let me know. You can pick it up at ...' /end
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today @davidasinclair is telling the world that he has achieved age reversal with chemical cocktails
he submitted the paper on June 30 & it was accepted on July 4 by a journal of which he is coeditor-in-chief
paper was sent to me 3 days ago by a reporter for comment
reporter was told it is a "groundbreaking study" & "the first chemical approach to reprogram cells to a younger state"
reason WSJ didn't cover that paper is that ppl have been reporting chemical compounds that drive conversion of cells to induced pluripotency for the last 10-15 years
all of the compounds in today's paper were previously reported by others, mostly in 2013
there's a peer review failure today doi.org/10.1016/j.cell… in which an individual with 59 collaborators claims to have tested the information theory of aging
he did not test the information theory of aging
the claim is that he induced dsDNA breaks that are easily repaired, don't cause a DNA damage response or mutagenesis or cell death--only an epigenetic change
he knows this is not true because his co-first author & he published this paper in dec '21
there are a few issues being addressed here. let’s start w safety
human placebo controlled trials have never shown adverse events attributable to Niagen. note that LDL-C is raised in humans w Basis & pterostilbene alone
the class of compounds to which NR belongs is vitamin B3
there are decades of human data on these molecules showing human safety. niacin is unique in causing flushing but nicotinamide was tested in large Australian skin cancer and was shown to be cancer-preventative in ppl
there’s a hierarchy of evidence w human RCTs (and meta-analysis of RCTs) on the top. human case reports & good quality rodent studies are lower. cell studies are lower. poorly conducted rodent and/or poorly conducted cell studies are garbage in/garbage out