Thread by @BadgleyLaurence

“ENDOMETRIOSIS ITCH”?
@medical_express. “Hope for millions of #IrritableBowelSyndrome sufferers as research identifies cause of #pain as 'gut itch'”. (1/5/20). ncbi.nlm.nih.gov/pmc/articles/P..

MY RESPONSE:
Primary physiologic mast cell receptor/activator found, & it has a higher density in IBS sufferers. Perhaps this is clue to cause of IBS. IBS is commonly associated with Hypermobility Spectrum Disorder

Physiologists know that mast cells and nerves touch & communicate, & that stretched tissues elicit mast cell activation. Because of estrogens, women have more elastic soft tissues than men.

Primary tissue stretch elicits neural stretch, which has been recently shown to evoke mast cell degranulation & itching.

Perhaps itch is nature’s way to alarm organism of threatening abuse of tissue regions, e.g., ant bite toxin needed to be cleared by blood drawn to itch-aroused dermatographism by the mechanical itch.

Most effective way to arouse intestine pain is to stretch gut with gas/fluids held back by kinks (think adhesions). No intestinal pain occurs with tissue cuts/burn. When female abdomen/pelvis invaded (surgery/laparoscopy) 100% time intestinal adhesions develop (Med literature).

Perhaps location/characteristics of Endometriosis pain same as IBS pain. During female menses secreted hormone Relaxin loosens connective tissues ➡️ pelvic tendons stretched/pained. Stretched intestinal walls ➡️ IBS pain. Is Endometriosis an illusion?

Certainly the presence & density of “endometrioma” spots of supposed “Endometriosis” are commonly found in women absent pain. As laparoscopies accrue, so do adhesions. Is Endometriosis an iatrogenic disease?

CONCLUSION: Mother Nature has not given up all her secrets. Hypermobile connective tissues are highly conserved in the population. They must provide an evolutionary advantage. Was the slinky bendy snake which gave Eve the shiny apple messaging her something?

POSTSCRIPT:
@cheryl_quist. Wait... are you saying that the digestive tract stretchy tissue issue (slow motility) is the culprit triggering MCAD/S?

ANSWER: The way intestinal muscle functions is that stretch of the muscle induces spasm. That is the genesis of peristalsis. Food goes in, intestinal muscle is stretched, spasms ensue to move things along.

I am theorizing that the intestinal connective tissues of hypermobile persons responds differently to a bolus of food than in non-hypermobile people. This could explain both IBS-d & IBS-c variations in hypermobile persons.

If mast cells are activated by excessive tissue stretch (Wang et al, 2010), then the “intestinal itch” theorized in the study that initiated this discussion (see above) might be explained by neural-mast cell activations related to excessive intestinal connective tissue stretch.

SEVERAL PERTINENT RECENT ENDOMETRIOSIS STUDIES:

A. Multifactorial Contributors to the Severity of Chronic Pelvic Pain in Women - PubMed; pubmed.ncbi.nim.nih.gov

B. Re: Surgical removal of superficial peritoneal endometriosis for managing women with chronic pelvic pain: time for a rethink? - Leonardi - 2020 - BJOG: An International Journal of Obstetrics & Gynaecology - Wiley Online Library; obgyn.onlinelibrary.wiley.com

C. “Ehlers-Danlos syndrome hypermobility type is associated with rheumatic diseases” ncbi.nim.gov/pmc/articles/p... (see my comments in an @threadreaderapp unroll) of 4/5/2020

The insights and clinical impressions herein are of my own inventions and gained via an iterative evidence based method of medical discovery. They are not intended for medical advice.

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