Ppl have asked me how do mitochondria fit into the CoV infection-NAD story. The 1st connection is that when cells detect dsRNA, MDA5 protein interacts with MAVS, which is in the mito membrane. This is required for interferon expression, which turns on the PARP induction program/1
Note that IFN is secreted, which means PARPs are induced in neighboring cells that haven't seen virus yet. This will disturb cytoplasmic NAD, which controls mito NAD, where most of the ATP is made /2
Virus needs ATP, GTP to make more virus but host cells need ATP, GTP, NAD, etc for their defense against virus. Good way of thinking about this is that the antiviral PARPs are the soldiers on a battlefield--these enzymes need NAD to stop the virus /3
Work done to date suggests that cytoplasmic NAD-boosting will give the PARPs more ammunition for the battle, while also supporting the mitochondrial functions needed for the function of our cells and tissues. More work needed, more work is in progress #staysafe
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today @davidasinclair is telling the world that he has achieved age reversal with chemical cocktails
he submitted the paper on June 30 & it was accepted on July 4 by a journal of which he is coeditor-in-chief
paper was sent to me 3 days ago by a reporter for comment
reporter was told it is a "groundbreaking study" & "the first chemical approach to reprogram cells to a younger state"
reason WSJ didn't cover that paper is that ppl have been reporting chemical compounds that drive conversion of cells to induced pluripotency for the last 10-15 years
all of the compounds in today's paper were previously reported by others, mostly in 2013
there's a peer review failure today doi.org/10.1016/j.cell… in which an individual with 59 collaborators claims to have tested the information theory of aging
he did not test the information theory of aging
the claim is that he induced dsDNA breaks that are easily repaired, don't cause a DNA damage response or mutagenesis or cell death--only an epigenetic change
he knows this is not true because his co-first author & he published this paper in dec '21
there are a few issues being addressed here. let’s start w safety
human placebo controlled trials have never shown adverse events attributable to Niagen. note that LDL-C is raised in humans w Basis & pterostilbene alone
the class of compounds to which NR belongs is vitamin B3
there are decades of human data on these molecules showing human safety. niacin is unique in causing flushing but nicotinamide was tested in large Australian skin cancer and was shown to be cancer-preventative in ppl
there’s a hierarchy of evidence w human RCTs (and meta-analysis of RCTs) on the top. human case reports & good quality rodent studies are lower. cell studies are lower. poorly conducted rodent and/or poorly conducted cell studies are garbage in/garbage out