Thread by @ElianaRubashkyn

On January 22 at the beginning of this year I had a suspicion about the protective effect of nicotine on the coronavirus.

I have several colleagues in China, I speak Mandarin, so it is easy to speak with them on WeChat, and many colleagues commented anecdotally on this particularity.
And today what was a suspicion is materializing.

In my comment on Twitter, I initially commented that nicotine seems to have a spherical impeding effect on the angiotensin II converting enzyme.

however after seeing how in New York a Hasidic Jewish community where many of its members who are heavy smokers and have ages around 70 years ended up having a mortality close to that of a 20-year-old person led other scientists to take this theory more seriously.

And after analyzing more than 54 articles where forecasts, virality and other related aspects were evaluated, it was established that my suspicion should be evaluated.

Nicotine has an interaction on nAChrs receptors, this interaction produces conformational changes in ACE2, which seem to be connected with the ACE arm and ANG II + AT1R, since nicotine is likely to generate an increase in expression and / or activity of renin

ACE and AT1R and the compensating arm ACE2 and ANG1-7 Mas R.
Nicotine probably regulates the expression or activity of ACE2-AT2R, in this way we can see how the possible contribution of acetylcholine receptors affects the regulation of ACE2.

Anecdotal evidence is getting much stronger, and that is why several scientists in France are recommending that their health personnel use nicotine patches.

Nicotine must be provided to patients in a vaping device, using a nicotine salt, the product needs and must be flavorless. And other details about concentrations and particular composition of the nicotine salts can't be shared as is part of my research.