Noubar Afeyan Profile picture
Apr 26, 2020 7 tweets 3 min read Read on X
(1/7) Some experts are questioning whether vaccines will work to prevent #COVID19 - whether they should be tested in humans without more proof in animals first, whether they will increase viral activity rather than reducing it,..
.. (2/7) whether antibodies will be neutralizing, whether we need T Cell response instead, whether immune response will prevent the virus, whether the immunity will last, whether we can manufacture enough or distribute it appropriately, whether a vaccine can be ready in 12, ..
.. (3/7) 18, 24, 36, 60 months if ever? Other experts question whether anti-virals will work or whether monoclonal antibodies are enough to fight the virus, etc. Did I miss any expert concerns?....
... (4/7) Questions like these fill the media coverage today and raise doubts about the efforts underway to develop treatments, vaccines and better tests. They also make those working on such approaches have to defend their work even before they have obtained the data to do so...
... (5/7) We are in a pandemic and we need many scientific and clinical teams pursuing their well-formed hypotheses with rigorous and well controlled experiments to discover and develop the solutions we so desperately need...
... (6/7) Such expert speculation of what might not work is slightly more useful than often criticized, non-expert assertions of what definitely will work ...
...(7/7) Let us all just keep working on our different solutions and hope the effective ones will emerge and create new experts on what actually did work! @JNJNews @pfizer @GileadSciences @BioNTech_Group @Vir_Biotech @CureVacAG @Regeneron @moderna_tx @FlagshipPioneer

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More from @NoubarAfeyan

Jan 12, 2021
Permission to leap: Welcoming biotech’s moment - A thread 👇 #JPM2021 #biotechmoment

flagshippioneering.com/stories/permis…
Nearly 40 years after the first biotechnology companies began applying primitive genetic engineering techniques to bacteria and producing human proteins as therapeutics, the power of modern biotechnology is now on full display.
Once defined by endless experimentation and expensive and low probability-of-success drug development, biotech is at the leading edge, fusing rapidly advancing molecular science with a deterministic path to products and impact.
Read 8 tweets

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