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1) For the 'it is just the flu' crowed. Without drastic countermeasures, deaths from seasonal influenza in the US between 2010 and 2019 varied between 12,000 and 61,000. cdc.gov/flu/about/burd… SARS-CoV-2 has within a very short period of time......
2)....and despite drastic countermeasures killed 80,000 individuals in the US as of today. The 2009 H1N1 pandemic, according to estimate (not official counts) killed approximately 280,000 people globally within the time frame of about 1.5 years......
3)....Today, we have reached this number as official case count with SARS-CoV-2 globally. After five months and drastic countermeasures. This is not seasonal flu. Even if some electric car producers want you to think that.
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Florian Krammer
@florian_krammer
1) I wanted share some data from a manuscript that just wen online at medrxiv.org/content/10.110…. This was spearheaded by the fantastic Dr. Ania Wajnberg in collaboration with many parts of the Mount Sinai Hospital and Icahn School of Medicine.
2) The data describes PCR and serology findings in the first 1343 plasma donors screened at Mount Sinai. Initially, there were two groups of donors: people who at some point had PCR confirmed COVID19 and people who had suspected COVID19 (but were never PCR confirmed).
3) The majority of these donors were mild cases. Now, almost all PCR-confirmed donors had antibodies, while the majority of the suspected COVID19 individuals did not. This tells us two things: a) the assay works and b) many people who think they had COVID19 might not have had it.
Read 10 tweets
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Florian Krammer
@florian_krammer
1) So, this is the first 'serious' preclinical data I have seen for an actual vaccine candidate. This one is an inactivated SARS-CoV-2 vaccine made by Sinovac. Seems to work in NHPs. biorxiv.org/content/10.110…
2) Their vaccine is in Phase I trials in China already. The company was also the only company that made a SARS-classic vaccine back then and pushed it into Phase I trials (NIAID had one as well, but they are not a company). Looked good back then too: intmedpress.com/serveFile.cfm?…
3) Here is the link to their Phase I/II trial registration: clinicaltrials.gov/ct2/show/NCT04… This is old-fashioned technology but that would make it easy to do it in other plants that manufacture inactivated vaccines too. I am a fan.
Read 4 tweets
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Florian Krammer
@florian_krammer
1) Here is my personal take on masks (and there are much more knowledgeable experts on this, who might disagree - follow up with @bencowling88 and @Don_Milton). Mask as part of the strategy to mitigate COVID19. They are PART, they are not a magic bullet.....
2).....However, they are efficient to stop spread to a certain extend. We currently don't have enough, therefore the message was, we should limit them to healthcare workers. However, they can be used strategically. People who interact a lot with other people....
3)....like supermarket personnel, hospital receptionists, security staff, police offers etc. should absolutely wear them. These people have a high likelihood to get the virus and transmit it to many others. If you already have them, it is good to wear them in places.....
Read 6 tweets

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