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Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
@edgarvlermamd
May 13, 2020 β€’ 12 tweets β€’ 17 min read β€’ Read on X
Scrolly
Association of Opioids and NSAIDs With Outcomes in CKD: Findings From the @CRICStudy ca. 2020 from @AJKDonline #Nephpearls #NephJC
#VisualAbstract by @AliMehdiMD
πŸ‘‰πŸΌ ajkd.org/article/S0272-… ImageImage
Pharmacological management of pain in patients with CKD ca. 2019 from @CJASN #Nephpearls #NephJC
πŸ‘‰πŸΌ cjasn.asnjournals.org/content/clinja… ImageImage
Association of NSAID Prescriptions
With Kidney Disease Among Active Young and Middle-aged Adults ca. 2019 from @JAMA_current @JAMAInternalMed #Nephpearls #NephJC
#VisualAbstract by @Stones__
πŸ‘‰πŸΌ jamanetwork.com/journals/jaman… ImageImage
Patterns of NSAID use & their association w/ other analgesic use in CKD ca. 2017 from @CJASN @CRICStudy #Nephpearls #NephJC
πŸ‘‰πŸΌ cjasn.asnjournals.org/content/clinja… ImageImage
This #NephJC discussion of NSAIDs will not be complete without mentioning Acute Interstitial Nephritis AIN ⚠️

πŸ‘‰πŸΌ Check our these slides from @wkupin

#Nephpearls #NephJC ImageImage
Drug interactions and opioid use
#NephJC #Nephpearls
πŸ‘‰πŸΌ cjasn.asnjournals.org/content/clinja… ImageImage
Opioids and CKD 🚦
#NKFClinicals #Nephpearls #NephJC ImageImageImageImage
Opioids also increase risk of altered mental state, falls and fractures ca. 2018 from @CJASN
#NephJC #Nephpearls
πŸ‘‰πŸΌ cjasn.asnjournals.org/content/clinja… ImageImage
Opioid Risk Tool ca. 2017 from @JASN_News
#Nephpearls #NephJC
πŸ‘‰πŸΌ jasn.asnjournals.org/content/jnephr… ImageImage
Effects of NSAIDs on the Kidneys
#Infographic by @GlomeruLai
#Nephpearls #NephJC
#Nephmadness 2οΈβƒ£πŸ€1️⃣9️⃣
πŸŽ™ thecurbsiders.com/podcast/146-ne… Image
NSAIDs and CKD ca. 2020 from @AJKDonline #Nephpearls
πŸ‘‰πŸΌ ajkd.org/action/showPdf… ImageImageImageImage
Synergistic nephrotoxicity was not observed w/ short-term NSAID + RAAS inhibitor treatment in the absence of concomitant diuretics

πŸ“Œ RAASi treatment may not be a reason to choose opioids in lieu of NSAIDs in this population

πŸ‘‰πŸΌ kidney360.asnjournals.org/content/kidney… ImageImage

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More from @edgarvlermamd

Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Feb 26, 2022
Advancing Evidence-Based Care in Diabetes and CKD
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls

πŸ‘‰ kdigo.org/wp-content/upl…
Holistic approach for improving outcomes in patients with Diabetes and CKD
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
Glucose-lowering agents in Type 2 Diabetes (T2D) and CKD: Indications and dose adjustments
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
Read 9 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Feb 26, 2022
.@goKDIGO Glomerular Diseases Guideline: Reflections on a Decade of Progress with @adrianliew8 @ReichHeather @Dr_KeishaGibson
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls

πŸ‘‰ kdigo.org/wp-content/upl…
IgA Nephropathy: A 1st step is in treating IgA Nephropathy is assessing "prognosis" based on data available at the time of biopsy

@goKDIGO suggest using the "prediction tool" that was derived from the largest & most geographically diverse cohort to date

#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
IgA Nephropathy: The @goKDIGO treatment algorithm recommends consideration of use of corticosteroids in patients with "persistent proteinuria >1g/day" if the risk/benefit profile is favorable

πŸ“Œ A GFR of 30 is considered a threshold for treatment

#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls
Read 13 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Feb 23, 2022
First clinical-grade porcine πŸ– kidney xenotransplant using a human decedent model ca. 2022 from @amjtransplant #NephJC #Nephpearls

#VisualAbstract by @NamrataYParikh

πŸ‘‰πŸΌ pubmed.ncbi.nlm.nih.gov/35049121/ Image
Attitudes to Clinical Pig Kidney Xenotransplantation among Medical Providers and Patients ca. 2020 from @ASNKidney360 #Nephpearls

kidney360.asnjournals.org/content/1/7/657 ImageImage
Paving the Path toward Porcine Organs for Transplantation ca. 2017 from @NEJM #NephJC #Nephpearls

nejm.org/doi/full/10.10… ImageImage
Read 4 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Jan 30, 2022
Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls

Multiple or metabolically active stones (stones that increase in size/ number w/in a year)

Children

Demographic groups not typically prone to stone formation

Stones other than those containing calcium ImageImage
Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja #Nephpearls

sciencedirect.com/science/articl… Image
Neglected analytes in the 24 hour urine: ammonium and sulfate ca. 2021 from @CO_Neph_Hype @ravineja #Nephpearls

πŸ‘‰ pubmed.ncbi.nlm.nih.gov/34798636/ ImageImageImageImage
Read 4 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Jan 26, 2022
PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @drM_sudha

jamanetwork.com/journals/jamap…
Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @md_abdulqader83

link.springer.com/article/10.100…
PREDNOS: Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome ca. 2019 from @bmj_latest #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @jbda19

pubmed.ncbi.nlm.nih.gov/31156083/
Read 5 tweets
Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Nov 17, 2021
Clinical Practice Guideline for the Management of Glomerular Diseases ca. 2021 from @goKDIGO #NephJC #Nephpearls
#VisualGraphics by @michaelturk6

Executive Summary pubmed.ncbi.nlm.nih.gov/34556300/
Full Guideline pubmed.ncbi.nlm.nih.gov/34556256/
The spectrum of glomerular diseases from @neilturn #NephJC #Nephpearls

πŸ‘‰ global.oup.com/academic/produ…
Nephrotic range proteinuria does "not always" mean nephrotic syndrome #NephJC #Nephpearls

πŸ‘‰ pubmed.ncbi.nlm.nih.gov/34556256/
Read 4 tweets

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