Renal bx from a woman in her late 50s, with a renal mass and metastasis. This biopsy is from the kidney. This was a highly infiltrative, high grade tumor with a desmoplastic background. Continued π #GUpath 
The referring institute reported + PAX8, CK7, - GATA3, CK20, TTF1. O/S diagnosis was collecting duct carcinoma.
Upon review by us, we realized that the pt was AA and ordered an INI-1 which was negative.
Diagnosis: Renal medullary carcinoma (confirmed by Hb electophoresis) π
Upon review by us, we realized that the pt was AA and ordered an INI-1 which was negative.
Diagnosis: Renal medullary carcinoma (confirmed by Hb electophoresis) π
True CDC of the kidney is extremely rare and is a diagnosis of exclusion. All tumors that look like a high grade adenoca, automatically get an INI-1. (I always exclude Uca and mets.)
RMC is usually a disease in younger pts, but can present at any age. #GUpath @PavlosMsaouel π
RMC is usually a disease in younger pts, but can present at any age. #GUpath @PavlosMsaouel π
To underscore the rarity of true collecting duct carcinoma, we see several cases of RMC here at MDA a year (I would guess about 20?) and less than 1 case a year that we call CDC. #GUpath @PavlosMsaouel
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