What’s the difference between colon and lung? Not an easy question when it comes to #KRAS. Our work out today in @CD_AACR today describe a strategy to overcome resistance to KRAS G12C inhibition in CRC. @sloan_kettering @Albert0Bardelli @BardelliLab bit.ly/2ACWd7H👇👇👇
Molecular response to KRAS G12C inhibitors is different in CRC and NSCLC models. CRC models show quick MAPK pathway rebound 
Receptor tyrosine kinases and EGFR dependency is stronger in CRC models
Combinatorial approach using #AMG510 and #Cetuximab induces cell proliferation arrest and #apoptosis
KRAS G12C mutant #organoids and patients-derived xenografts show response to this combination, with complete tumor regression in vivo #CRC #KRAS #sciencetwitter
