Discover and read the best of Twitter Threads about #CRC

Most recents (24)

@TumorBoardTues @shafiarahman_ @RischZack @MPishvaian @ColonCancerCoal @colontown @coloncancermike @GlobalCRC 2/6 #TumorBoardTuesday
Thurs Case🎀

#mCRC & #EGFR tx:
✅Anti-EGFR useful in RAS/RAF WT; debate re: timing vs anti-VEGF
✅Pt centered discussion including SEs 🗝️
✅Emerging data: EGFR re-tx, using ctDNA to guide

📚@shafiarahman_ @RischZack’s thread:…
@TumorBoardTues @shafiarahman_ @RischZack @MPishvaian @ColonCancerCoal @colontown @coloncancermike @GlobalCRC 3/6 #TumorBoardTuesday
🎥 TBT in a vid- Part 1:

@shafiarahman_ 's approach: pt eligible for EGFR-directed tx in #metastatic #CRC
🔹RAS/RAF WT- more important than side
🔹Bev or pan 1L? Trend toward pan, but is 🗝️actually that pt gets anti-EGFR in tx, 🚫necessarily 1L?
@TumorBoardTues @shafiarahman_ @RischZack @MPishvaian @ColonCancerCoal @colontown @coloncancermike @GlobalCRC 4/6 #TumorBoardTuesday
🎥 TBT in a vid- Part 2:

@shafiarahman_ gives us a preview of what might be coming in #EGFR directed tx in #mCRC
🔹Re-challenge based on ctDNA clearance of resistant clones; pts w resistance to EGFRi benefit later as the tumor evolves again
🔹New combos!
Read 12 tweets
@TumorBoardTues @MPishvaian @JohnEbbenMDPhD @CCAlliance 1/22 #TumorBoardTuesday #ColonCancerAwarenessMonth #OncTwitter @shafiarahman_

62 yo 👨🏼‍🦳 asymptomatic
🔦 Screening colonoscopy - sigmoid mass
🔬Biopsy + for pMMR/MSS adenocarcinoma
🩻Staging CT + for unresectable liver mets

🤨What first line systemic treatment would you choose?
@TumorBoardTues @MPishvaian @JohnEbbenMDPhD @CCAlliance @shafiarahman_ 2/22 #TumorBoardTuesday @MPishvaian @JohnEbbenMDPhD #CRCAwarenessMonth

👨🏼‍🦳started on first line FOLFOX
🧪NGS testing
TMB low
ERBB2 negative
ATM mutation
@TumorBoardTues @MPishvaian @JohnEbbenMDPhD @CCAlliance @shafiarahman_ 3/22 #TumorBoardTuesday #GI23 #CRCAwareness
👩🏻‍🏫Mini tweetorial 1👨🏻‍🏫

↩️Left side tumors more common:
HER2 amp

↪️Right side tumors enriched for
BRAF V600E mutation
Read 29 tweets
@TumorBoardTues @brian_rini @JVentoMD @MPishvaian @Uromigos @JoshLangMD @renalandurology @UroDocAsh 2/5 #TumorBoardTuesday
Thurs Case🎀

✅ Pembro ONLY approved adj IO in RCC
✅ 3 recent trials w IO failure: nivo/ipi, atezo & periop nivo
✅ Must balance risks vs benefits- shared decision-making 🗝️

📚@brian_rini @JVentoMD’s thread:…
@TumorBoardTues @brian_rini @JVentoMD @MPishvaian @Uromigos @JoshLangMD @renalandurology @UroDocAsh 3/5 #TumorBoardTuesday
Thurs Case🎀

🎥 TBT in a video
High risk #RCC, pembro= DFS advantage, but w cost- Grade 3 AEs= 32%. High risk #RCC defined by:
🔹Stage II w sarcomatoid features
🔹Stage III+
🔹Regional LN+/M1 disease

Quick overview of adj IO decision making:
@TumorBoardTues @brian_rini @JVentoMD @MPishvaian @Uromigos @JoshLangMD @renalandurology @UroDocAsh 4/5 #TumorBoardTuesday
Thursday Case🎀

📷 TBT in an image
Nomograms, including ASSURE from @FoxChaseCancer can provide addtl context re: risk of recurrence–but remember:

⭐️Every patient is an individual!

Our guide to help lead discussions w pts re: risks/benefits of adj IO:
Read 9 tweets
#FIFAWorldCup Here are today's four fixtures:

#HRV vs #BEL (1500 GMT)
#CAN vs #MAR (1500 GMT)
#JPN vs #ESP (1900 GMT)
#CRC vs #GER (1900 GMT)

Follow our #Qatar2022 coverage here:👇
#FifaWorldCup full-time score:

#CRO 0 - 0 #BEL

#Qatar2022 ImageImageImageImage
#FIFAWorldCup full-time score:

#CAN 1 - 2 #MAR

CAN: (OG) Aguerd
MAR: Ziyech, en-Nesyri

#Qatar2022 ImageImageImageImage
Read 5 tweets
Going into the last match, here's what each team in Group E needs. #FIFAWorldCup #ESP #JPN #CRC #GER #GroupE

A win by ESP, JPN, CRC sees respective team through to the knockout.

GER must win, and need some help.

ESP can lose and still go through. Others are out if they lose.
ESP 🇪🇸
1. win or draw vs JPN
2. loss => probably OK, it can be complicated

We'll get to the complications below.
JPN 🇯🇵
1. win
2. draw + CRC-GER draw or GER victory by exactly 1 goal. GER gets the tiebreaker (GD) by winning by 2 or more goals.
Read 7 tweets
Post-Match Report 🧵📊

Spain 🇪🇸 7-0 🇨🇷 Costa Rica

#ESPCRC #Qatar2022 #FIFAWorldCup #ESP #CRC
Spain's starting XI passing sonars
Costa Rica's starting XI passing sonars
Read 11 tweets
¡El último boleto a #Qatar2022!
Costa Rica #CRC 🇨🇷 y Nueva Zelanda #NZL 🇳🇿 se enfrentan en Doha 🇶🇦 por un lugar en el mundial.
Costa Rica #CRC 🇨🇷 🆚 Nueva Zelanda #NZL 🇳🇿
Costa Rica #CRC 🇨🇷

Debutó en una #FIFAWC en #Italy1990 🇮🇹, donde compartió el Grupo C con Escocia #SCO 🏴󠁧󠁢󠁳󠁣󠁴󠁿 (V), Brasil #BRA 🇧🇷 (D) y Suecia #SWE 🇸🇪 (V). Sumó 4 puntos y clasificó a los Octavos de Final, donde cayó ante Checoslovaquia #TCH.
Participaciones en #FIFAWC: 5️⃣

Su primera participación en un mundial: #Italy1990 🇮🇹.
Su última participación en un mundial: #Russia2018 🇷🇺.
Mejor Participación: Cuartos de Final en #Brazil2014 🇧🇷.
Read 13 tweets
Selecciones de CONMEBOL en Repechajes para la Copa del Mundo #FIFAWC.
Hasta el día de hoy, se han jugado 10 repechajes para una Copa del Mundo en los que haya participado una selección de CONMEBOL.
¿Qué selecciones ya jugaron un repechaje? ¿Cómo les fue? ¿Rivales? ¿Cuándo?
Repechaje Intercontinental para #Chile1962 🇨🇱.
Paraguay #PAR 🇵🇾 🆚 México #MEX 🇲🇽
Ida: #MEX 1 - #PAR 0
Vuelta: #PAR 0 - #MEX 0
Clasificado al Mundial: México #MEX 🇲🇽
Repechaje Intercontinental para #WM1974 🇩🇪.
Chile #CHI 🇨🇱 🆚 Unión Soviética #URS
Ida: #URS 0 - #CHI 0
Vuelta: #CHI 2 - #URS 0 (W.O.)
Clasificado al Mundial: Chile #CHI 🇨🇱
Read 13 tweets
¡La última ronda de las #Eliminatorias al Mundial de #Qatar2022 arrancó el día de hoy!
La lucha de los últimos 3 cupos al mundial. 🔥
• 1 Boleto CONMEBOL 🆚 AFC
• 1 Boleto CONCACAF 🆚 OFC
• 1 Boleto Europeo. Image
En un emotivo regreso, Ucrania #UKR 🇺🇦 dejó fuera a Escocia #SCO 🏴󠁧󠁢󠁳󠁣󠁴󠁿 y se enfrentará a Gales #WAL 🏴󠁧󠁢󠁷󠁬󠁳󠁿 en la final por el último boleto europeo a #Qatar2022.

#SCO 🏴󠁧󠁢󠁳󠁣󠁴󠁿 no juega un mundial desde #France1998.

☑️ #UKR 🇺🇦 (2006) y #WAL 🏴󠁧󠁢󠁷󠁬󠁳󠁿 (1958) buscan jugar su segundo mundial. ImageImage
¡Las #EuropeanQualifiers camino a #Qatar2022 llegaron a su final y el último boleto fue para Gales 🏴󠁧󠁢󠁷󠁬󠁳󠁿!
☑️ Jugará su segunda Copa del Mundo.
¡Bienvenidos a #Qatar2022, @FAWales! ImageImage
Read 8 tweets
1/12 #TumorBoardTuesday

🔬🧬Discussion on #ColonCancer and BRAFv600E disease w dMMR led by @FlavioRochaMD
➡️Here is this week's Thurs Case🎀

👉👉 Don’t forget to pick up🆓 #CME credit by answering 2 quick ❓
Now…we’re off to the races!
2/11 #TumorBoardTuesday
Thurs Case🎀

#CRC 🚫one disease!
✅Diff 🧬subtypes that define tx sensitivity
✅BRAFv600E is bad–but may be ⬆️sensitive to IO w MLH1 meth
✅Neoadj tx: 🦊FOXTROT= poss benefit, depends on subgroup
✅Keynote177: IO= way to go in dMMR!
3/12 #TumorBoardTuesday
Thurs Case🎀

Take🏠messages (cont’d):

✅ATOMIC will help answer ❓chemo/IO combo upfront is best in dMMR and BRAFv600E
✅POLEM trial also looking at adjuv IO in dMMR @shafiarahman_

📚We captured the discussion in this moment:…
Read 18 tweets
😳🤯The hour flew by & none of us noticed!!

🙏🏽 @FogacciJoao for bringing the 🇧🇷 flair to #TumorBoardTuesday & #GastricCancer!!

🏆Remember your🆓CME

Look for Case Wrap Up🎀 04/28/22

📅Mark your calendar for 05/10/22 8pm ET when @FlavioRochaMD joins our #VirtualTumorBoard!!
Remember #TumorBoardTuesday education goes beyond Twitter - we offer 🆓 CME!!

Pick up your🏆#CME & NOW #MOC(‼️) by answering quick questions regarding a case similar to @FogacciJoao’s‼️


🔗 post rationale:

#PostTest Q1️⃣ #CME #TumorBoardTuesday @MPishvaian

🤔Now that @FogacciJoao schooled us through updates on immunotherapy for #GastricCancer, how would you answer these 2 quick ❓

🧬 Which are potentially useful immunotherapy biomarkers in gastric cancer?
Read 21 tweets
#TBTWebinar is back ‼️
🥼 @MPishvaian @BreastCancerMD1 @Latinamd @BenWestphalen

Pretest 👉
Claim credit 👉

Supported by AstraZeneca Pharmaceuticals & Daiichi Sankyo, Inc…
#TumorBoardTuesday HER2 #TBTWebinar 🔑

➡️HER2 activity requires receptor dimerization

➡️HER2 is frequently overexpressed in multiple cancers
✅Protein⬆️due to gene🧬 amplification
✅Constitutive activation due to activating🧬mutation Slide 3 of #TBTWebinar
#TumorBoardTuesday HER2 #TBTWebinar 🔑

➡️HER2 (ERBB2) alterations occur in multiple cancer types
✅Breast Ca 25%
✅Gastric Ca 22%
✅GE jxn Ca 32%
✅CRC 5%
✅Lung Ca 6 to 30%
✅Biliary Ca 5 to 20%

🤔There is some disease specificity re: overexpression vs activating🧬mutation Slide 4 of #TBTwebinar
Read 14 tweets
@rebelliousgut @MondayNightIBD @southasianIBD @ibdesis @Empoweringpts9 @DCharabaty @crohnsbabble @LivingWithUmeed @vkckiranpullela @TheMaveilousGut @dunung_ruchita 1/ I'm Tina from 🇺🇸 co-founder of Team @ibdesis. We are proud to lead #PatientExperience on @MondayNightIBD to discuss specific aspects of #SouthAsianIBD experience. We hope to improve care & reduce disparities in our community around the 🌍 thru @southasianIBD. #MondayNightIBD
@rebelliousgut @MondayNightIBD @southasianIBD @ibdesis @Empoweringpts9 @DCharabaty @crohnsbabble @LivingWithUmeed @vkckiranpullela @TheMaveilousGut @dunung_ruchita 2/ Even though my dad suffered from #Crohns, when I presented with #IBS #constipation, #GERD, joint pains & eye issues as a child, no one made the connection or escalated it to a gastroenterologist. #MondayNightIBD #SouthAsianIBD
@rebelliousgut @MondayNightIBD @southasianIBD @ibdesis @Empoweringpts9 @DCharabaty @crohnsbabble @LivingWithUmeed @vkckiranpullela @TheMaveilousGut @dunung_ruchita 3/ When my dad passed from #CRC, my family went into poverty & couldn't afford health insurance. Though I was symptomatic as a child, I didn't have a #colonoscopy until 22 when I got my 1st job. That's when I received my very delayed #IBD diagnosis. #MondayNightIBD #SouthAsianIBD
Read 11 tweets
Good Morning #GImedTwitter

🌅🌄🌇Whether you are waking up in San Francisco…..or not (Curse you COVID-19😡)

🧑‍🏫Get ready for 3 packed days of presentations at #GI22

And to get the🧠started, we are going to share our
Top 10 Targeted Therapy Abstracts🎯


Once again HER2🎯💊is everywhere #GI22

👉The DESTINY trials have been👍4⃣T-DXd

➡️T Yoshino, et al "RAPID" Abs 119
⏩53 "Group A" HER2+ RASWT CRC pts
⏩ORR 45%, mOS 15.5 mos
👍Even with prior HER2 Tx
😨But GR>=3 AEs in 65% of pts, 9% ILD
#TumorBoardTuesday #GI22

✅DESTINY-Gastric 01
➡️K Yamaguchi, et al "RAPID" Abs 242
⏩Randomized Ph II trial of >=2nd line💊
👉T-DXd vs. Physician’s choice (PC) which was Iri or Paclitaxel
⏩mOS 12.5 v 8.9 mos
⏩ORR 51% vs 14%
😨But Grade >= 3 AEs were 86% vs 57%
Read 11 tweets
Pls join us in welcoming @JohnEbbenMDPhD to #TumorBoardTuesday!! 🎊

Dr Ebben is an onc fellow from WI, interested in🧬med & immunotherapy. He’ll also debate🧀curds & the best🍦custard in WI! He’ll be assisting with case wrap up🎀

We’re excited to have him!! #TBTFellow 1/17 White male with short brown...
2/17 #TumorBoardTuesday Thursday Case🎀(08/24/21)

Bringing #ctDNA to bear to improve pts🙌🏽 @pashtoonkasi shows us how we can♻️ 🎯therapies to extend survival.

We go deep -🔬molecular biology➡️clinical trials➡️pt case.

👉🏽Don’t forget🆓#CME credit:
3/17 #TumorBoardTuesday Thursday Case🎀(08/24/21)

📚We captured as much of @pashtoonkasi's discussion as we could in this moment:
#ColorectalCancer #CRC #OncTwitter…
Read 19 tweets
El día de ayer durante la final de #bmxfreestyle los atletas Daniel Dhers (#VEN) y Kenneth Esquivel (#CRC) compitieron con una cinta adhesiva blanca en la parte derecha de sus cascos, la cinta sólo estuvo en la final no en días previos, explicó la razón de esto (hilo)
El casco integral al ser el elemento de mayor importancia tanto en seguridad como fotografía para un ciclista es fabricado a medida por su principal patrocinante donde aprovechan la oportunidad de ocupar el mayor espacio para publicitar su marca, tanto Dhers como Tencio...
Son riders de la reconocida marca Austriaca de bebidas energéticas @redbull, pese a que el reglamento olímpico prohíbe publicitar y nombrar patrocinantes durante el evento, la marca supo hacerla esta vez, metiendo implícitamente su marca en el nombre del país de sus riders...
Read 6 tweets

A partir das 08h, ao vivo na Globo, SporTV e BandSports!
#Tokyo2020 #JogosOlímpicos
20 MINUTOS! Bruno e Ketleyn já estão no preparo!

📸 Christian Dawes/COB
Read 101 tweets

THANK YOU to @KristenCiombor for leading us through a🗣️on pMMR CRC w/ dMMR liver mets

AND thank you for @fireflyann for leading our #PatientExperience 🗣️as well

👉Don’t forget your🆓#CME credit-answer 3 quick❓
Here's the postest🔗
Thursday Case🎀(Reverse jet-lag edition✈️)
(07/06 and 07/07/21)

We🗣️ #ColorectalCancer and:
✅1st line Tx for dMMR met CRC
✅✔️ing MMR status EVEN in patients with Lynch Syndrome
✅Tumor heterogeneity

We captured the🗣️in this moment:…
Thursday Case🎀
(From 07/06 and 07/07/21)

In the #PatientExperience 🗣️we added:
✅Defining the "lingo", e.g.
👉dMMR = MSI-high
👉pMMR = MS-stable
✅Ensuring tumor testing - and🗣️results w/ docs

Also captured in this moment:…
Read 18 tweets
Gather around with a snack and ☕️!! We’ll begin with @fireflyann in ≈ 30mins!!

Please share and invite other members of the cancer community!

#TumorBoardTuesday #PatientExperience #ColorectalCancer @MPishvaian @KristenCiombor @Empoweringpts9
A couple of reminders.
If you need medical advice, or questions about your treatment or your personal care, please speak with your in-person care team.

#TumorBoardTuesday #PatientExperience #ColorectalCancer #CRC 1/3 @fireflyann reminders.  If you need medical advice, or questions about y
Everyone responds to treatment different, please be mindful of other’s experiences.

#TumorBoardTuesday #PatientExperience #ColorectalCancer @fireflyann 2/3 Reminder:  Everyone responds to treatment different, please
Read 6 tweets
A short thread about our recent publication on the incorporation of the Convention on the Rights of the Child into national law with @ProfLauraLundy @BronaghByrneQUB @LawUCC @childlawucc @ChildRightsQUB 1/7
States around the world are taking action to give further effect to the Convention on the Rights of the Child in national law, including full incorporation of the #CRC and harmonising law and policy. Our book subjects this trend to international and comparative analysis. 2/7
Writing from national perspectives, from Australia to China, Mexico to Scotland, South Africa to Norway, authors explain the diverse and creative ways in which states have implemented and incorporated the #CRC giving children's rights real force and meaning at national level 3/7
Read 8 tweets

🙏for joining &⚖️in on a robust🗣️ with A LOT of deep🔬on NRG-1 fusion+ #CRC led by @benweinbergmd

➡️Here is this week's Thursday Case🎀

👉👉Don't forget to pick up your🆓#CME credit by answering 2 quick❓

Here is the post-test🔗
Thursday Case🎀
(Case from 04/06/21)

We discussed #colorectalcancer and:
✅ChemoTx choices and sequencing
✅5FU cardiotox
✅KRAS and other🧬alterations
✅And of course all about NRG-1

We captured as much as we could in this moment:…
Thursday Case🎀
(Case from 04/06/21)

@benweinbergmd presented a case of a patient with met #CRC

➡️What chemo after metastasectomy
➡️💪evidence for FOLFOXIRI+mAb for metCRC
Read 13 tweets
#JPM2021 $GH #GuardantHealth my highlights:… #LiquidBiopsy they are at the forefront of #Epigenomic profiling (Methylation+Fragmentomics) Image
#LUNAR1 #CRC bringing #Epigenomic profiling to recurrence testing with #Methylation profiling (no fragmentomics?) Image
Read 5 tweets
Folks! We return for #HOTrainees with the exciting #Day2 @myESMO #ESMO20 and some more #practice relevant studies in #breastcancer #ProstateCancer #lungcancer #GI, so sit back, relax and lets go through some data (#HO #trainee-style!) Shout out to @peters_solange @OncoAlert
1. #BreastCancer: We have #monarchE and #IMPassion031 hoping to hear from experts @ErikaHamilton9 @NicoleKuderer @DrSGraff @matteolambe @tmprowell @GeorgeSledge51 @VukovicPetra for more insights- please link to your discussions here for #trainees:
1. A) #monarchE: use of #abemiciclib in HR+, HER2-,high risk #EBC in addition to endocrine therapy.
Current #SOC: adjuvant ET (5-10 years)
#monarchE: #Abemaciclib + ET iDFS HR 0.747, here's a great summary by @ErikaHamilton9 for @OncoAlert :
Read 11 tweets
So excited for the #NtlMtg20 to kick-off!!!

Ready to hear from @NASPADavid, Aimee, Courtney & so many other amazing people in our field!
Really awesome that @hecaod has Closed Captioning & an ASL interpreter on screen! #NtlMtg20 Image
And it's a GREAT time to say Happy 5th Year Anniversary to @hecaod!!! #NtlMtg20
Read 75 tweets

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