Interestingly 16/25 highlighted genes are in fact the closest gene to the lead SNP.
64%, very similar to eQTLs, pQTLs and metabolite QTLs.
I looked across all the loci at all genes involved in "rare cardiac diseases"
orpha.net/consor/cgi-bin…
PLN encodes phospholamban, a regulator of SR Ca2+ release.
en.wikipedia.org/wiki/Phosphola…
Did you know the Drosophila homolog of FGFR1 is called "heartless"? I didn't. But it looks like 3 FGF genes and 2 FGFR genes are implicated in this PR GWAS.
en.wikipedia.org/wiki/Heartless…
![](https://pbs.twimg.com/media/EY0I32kXgAICCaU.jpg)
pubmed.ncbi.nlm.nih.gov/11994297/