Thread by @CyrilPedia

'A recent report found that ACE2 is expressed in neurons, astrocytes, and oligodendrocytes. Expression of ACE2 was also highly concentrated in the substantia nigra, ventricles, middle temporal gyrus, posterior cingulate cortex, and olfactory bulb'

jamanetwork.com/journals/jaman…

Here's the recent report

'Here we investigated the ACE2 expression in the brain by analyzing data from publicly available brain transcriptome databases'

biorxiv.org/content/10.110…

'There is increasing evidence that human and nonhuman CoV invade peripheral nerve terminals, spread retrograde along nerve synapses, and gain access to the CNS'

Which goes to this 2018 ref on OC43

jvi.asm.org/content/92/17/…

'Direct entry along the olfactory nerve is another potential mechanism for SARS-CoV-2 entry to the CNS. In a transgenic mouse model that expresses ACE2, mice inoculated with SARS-CoV-1 intranasally showed that virus invaded the CNS via a transcribrial route.'

However

'Emerging reports suggest that sustentacular and stem cells in the olfactory epithelium express ACE2 and are vulnerable to SARS-CoV-2 infection, while olfactory sensory neurons do not express ACE2, suggesting SARS-CoV-2 cannot gain access to nerve cells.'

People really need to stop saying this based on a single paper (with a single figure) using pseudovirus infection of MT-2 and A3.01 cell lines and some very unconvincing FACS data

"It has been demonstrated that T lymphocytes allow SARS-CoV-2 infection"