Thread by @StephenVLiu

#ASCO20 Fresh off the @US_FDA approval, abstract 9527 outlines biomarker results from the Japanese substudy of RELAY (phase III trial of first line erlotinib vs erlotinib + ramucirumab in #EGFR mutant #NSCLC). Overall, addition of ram improved PFS (HR 0.59) #OncoAlert #LCSM

#ASCO20 The Japanese biomarker substudy included 131 pts with full results. Baseline EGFR allele frequency did not seem to distinguish outcome (within a treatment arm) but clearance did - those with no detectable circulating EGFR at cycle 4 (and receiving ram) had best outcomes.

#ASCO20 Differences in HER2 and MET copy number also noted over time. Pharmacodynamic studies like this may help identify patients who need modifications to their treatment for better long term control. Trial could be: if ctDNA clear at 4m, continue. If not, add/modify. #LCSM

#ASCO20 Baseline TP53 status also noted but no predictive/prognostic impact in this study. We know from others that TP53 predisposes to #SCLC transformation in #EGFR NSCLC but not sure ram would impact that (awaiting chemo intervention trial by @HelenaYu923) #OncoAlert #LCSM