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New study on HCQ for post exposure prophylaxis. TL;DR it didn't work...
...but a well done RCT has many other gems to uncover, here we have good data on the risk of transmission following unprotected exposure...about 14%
But be careful with that number because 100 people were excluded from randomization because they got sick within 24 hours, and we probably shouldn't exclude them in our assessment of the rate of infection. So that comes to 23% That's higher than I would have expected.
Be care out there.
Wear a mask.
Wear eye protection
forgot to leave a link to the study. My bad. Thanks @misterchambo for pointing out the oversight

nejm.org/doi/full/10.10…
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Joel Topf, MD FACP
@kidney_boy
1. Last Wed March 11, the @ASNKidney did a webinar on COVID-19. I highly recommend it.

Link to recording: asn-online.org/ntds/resources…

I am going to do a #Tweetorial covering the high points.
2. Alan Kliger (@AlanKliger) started off discussing the transmissibility of COVID19. Note: Alan will be on Twitter Tuesday night to discuss COVID19 at #NephJC at 9EDT.

Nice pic demoing the R0 of COVID19. Hey, at least it's not small pox! Image
3. Then he showed the relative lethality of COVID19. Hey at least it's not MERS. Image
Read 16 tweets
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Joel Topf, MD FACP
@kidney_boy
1/ This is the 4th #tweetorial #MedThread on contrast nephropathy from my grand rounds. For more information take a look here: pbfluids.com/2019/11/contra…
2/ The 1st #Tweetorial dealt with the lack of evidence tying contrast to AKI. The 2nd looked at the outcomes of patients who develop AKI after contrast. The 3rd looked at cholesterol emboli as an etiology of AKI after cath. Links to all the tweetorials are at the blog post above
3/ This #tweetorial is a response to the concern that “All of that epidemiology information showing contrast is okay is fine and well but I’d rather be safe than sorry so I will avoid contrast in my CKD patients anyways”
Read 8 tweets
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Joel Topf, MD FACP
@kidney_boy
1/ This is the third #tweetorial #MedThread on contrast nephropathy from my grand rounds. For more information take a look here: pbfluids.com/2019/11/contra…
2/ The 1st #Tweetorial looked at the lack of evidence tying contrast to AKI. The 2nd looked at data tying poor clinical outcomes to CIN and if it was causal or not (it’s not).


3/ This #Tweetorial #MedThread deals with the major question, “if it’s not CIN causing AKI, what is it?”
Read 13 tweets

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