Many new studies suggest that one of the fundamental assumptions about COVID that ๐๐ซ๐๐ง๐ฎ๐ค๐ฃ๐ is susceptible, may be wrong.
CAUTION: However, this doesnโt mean that we relax any precautions, coz the % of population susceptible is very high, & COVID is deadly.
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CAUTION: However, this doesnโt mean that we relax any precautions, coz the % of population susceptible is very high, & COVID is deadly.
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Study in @CellPressNews found 70-100% of people recovering from COVID have good T cell immune responses targeting the spike protein & other viral proteins. But they also found 40โ60% of people who never had COVID also had T cells reactive to SARS-CoV2. cell.com/cell/fulltext/โฆ
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For the group they considered unexposed to COVID they used cells collected in 2015-2018. So no chance of exposure to COVID.
These findings suggest that immune responses we generate to common corona viruses (~20% of common cold) may be cross reactive & protect against COVID.
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These findings suggest that immune responses we generate to common corona viruses (~20% of common cold) may be cross reactive & protect against COVID.
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I heard from a person present at a meeting yesterday, that Dr. Fauci acknowledged that this finding of cross immunity from T cell mediated responses to prior corona virus infections is indeed possible. Which brings hope, but we need to learn a lot more.
@ASlavitt
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@ASlavitt
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We donโt know if the T cell mediated responses against COVID in the Cell paper in unexposed people is protective. But based on SARS animal studies & data that in H1N1 presence of cross reactive cells led to less severe infections, the authors hope that this can be protective.
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There are other pieces of supportive data. Here is one.
6/ immunology.sciencemag.org/content/5/48/eโฆ
6/ immunology.sciencemag.org/content/5/48/eโฆ
Iโve pointed out earlier reasons to think this is the case based on what happened in Wuhan, Lombardy, and NY.
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But a great thread explaining susceptibility is one that was posted by @Rfonsi1 yesterday.
Check it out.
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Check it out.
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This is quite amazing. @vmontori @Rfonsi1 @DrSidMukherjee
@vmontori had previously hinted that overall Peru has major drop in COVID despite no change in behavior.
@vmontori had previously hinted that overall Peru has major drop in COVID despite no change in behavior.
Link to earlier thread on how the natural history in hotspots may shed some light on susceptibility.
