1/ This #4ofjuly, have fun, enjoy your family/friends, but please #BeSafe. Express your politics at the ballot box and in your speech. But not wearing masks and flaunting social distancing measures? That makes you a danger to yourself and others, including those you love. #COVID
2/ Cults are dangerous. Leaders who lie are dangerous. Please protect yourself, your family & your community. If you wait to see this with your own eyes, it'll be too late. The US is careening into a long-term nationwide disaster: the loss of lives & damage to the economy. #COVID
3/ If you've had unprotected, high-risk sex, get STD/HIV testing. Many don't have symptoms. ~1/3 of those infected w/ #coronavirus don't have symptoms, but can infect others. If you engage in unsafe pandemic behavior (not wearing masks or social distancing), get #COVID tested.
4/ We're still really bad at predicting who'll get sick with #coronavirus #COVID. Many who are infected will be just fine. But the way the US is heading, many are going to get very sick, and many will die. This is a preventable tragedy.
5/ This #4ofjuly, let's celebrate American strength in the face of crisis. Let's show that we're stronger than the virus, that we can unite against the #coronavirus, that we can defeat #COVID. //

• • •

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More from @celinegounder

Apr 29
1/ H5N1 bird flu candidate vaccine viruses have been identified:
(jump to 1:33)
🔹2 are "well-matched" to H5N1 infecting dairy cattle
🔹but how "well-matched" are they really? this conclusion is based on ferret dataastho.org/education/hpai…Image
2/
🔹Candidate vaccine viruses are used to make antigen (i.e. the target you want the immune system to see) for vaccines.
🔹Adjuvant has also been stockpiled.
🔹Adjuvants help strengthen the immune response to antigen in vaccines. Image
3/
🔹100s of thousands of doses of candidate antigen + adjuvant have been manufactured for use in clinical studies.
🔹2 safety/immunogenicity studies are being conducted.
🔹@ASPRgov is working with @US_FDA & industry to figure out a regulatory pathway for the use of these doses.
Read 4 tweets
Apr 29
1/ There are still lots of unanswered questions re: H5N1 bird flu

🔹How quickly is the virus mutating and evolving?

A PB2 E627K mutation was found in the human case in Texas, but not seen in birds or cows.
(1:04:50)astho.org/education/hpai…
2/ The PB2 E627K mutation has been seen in other human cases of H5N1.

It is one step towards mammalian (but NOT human) adaptation in experimental studies. (h/t @RickABright)
3/ The PB2 E627K mutation may have developed in the human Texas case.

It has not been seen in Texas dairy cattle or birds, nor in wild birds or poultry.
Read 8 tweets
Apr 25
1/ Stemming the spread of H5N1 bird flu
🔹The federal government is ramping up testing of dairy cows
🔹Cows will now have to be tested before being transferred to another state
🔹H5N1 viral fragments detected in grocery store milk
🔹The risk to humans remains low at this time
2/ Remember PCR tests from COVID?

They can be positive even after you’ve recovered because they’re picking up dead virus.

Some PCR tests on pasteurized milk from grocery stores have come back positive for bird flu... but that could just be dead virus.
3/ Pasteurization has worked for over a hundred years to protect consumers from bacteria and viruses.

There’s no reason to think pasteurization won’t also work to kill the bird flu virus, but scientists are confirming that with testing anyway.
Read 16 tweets
Apr 23
1/ H5N1 bird flu has been detected in the milk supply




We currently believe the milk supply to be safe.

Some other key points:washingtonpost.com/health/2024/04…
nytimes.com/2024/04/23/hea…
fda.gov/food/alerts-ad…
2/ The levels of virus fragments being found in milk by PCR are high.

Milk from different cows is combined into big vats.

You wouldn't see such high levels of virus if only a couple cows were infected... it would be diluted down.

This implies many cows have been infected.
3/ I suspect there's been a ton of asymptomatic transmission among cows.

They've only been testing symptomatic cows.
Read 8 tweets
Apr 2
1/ The 2nd human case of H5N1 bird flu was reported in the US yesterday.

This case was in Texas & likely involved transmission from an infected cow🐄 to this individual.

The 1st case was reported in Colorado in 2022.

with @tonydokoupil @GayleKing @nateburleson
2/ The person in Texas became ill with H5N1 bird flu after direct contact with infected dairy cattle🐄.

The patient's primary symptom was conjunctivitis (i.e. pink eye).

The patient is isolating & is being treated with an antiviral for flu... as are their close contacts.
3/ The risk to the general public is believed to be low at this time.

Risk factors for H5N1 bird flu:
🔹Close contact with animals suspected of having H5N1 bird flu
🔹Close contact with someone infected with H5N1 bird fluImage
Read 23 tweets
Mar 18
1/ Health workers fear it's profits before protection as CDC revisits airborne transmission by @KFFHealthNews' @amymaxmen

So incredibly brave of Dr. @sonyastoked to speak out:
nbcnews.com/health/health-…
Image
2/ Image
3/ Image
Read 7 tweets

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