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Thread on Fluorine (F) containing APIs (F-APIs):

Around 30% of Modern drugs & about half of the blockbuster drugs contain fluorine atoms.

F-applications are on a continuous surge. It took more time to understand and develop the Chemistry of Fluorine (1/1)
due to complexities associated with it. Lately, Medicinal Chemist discovered importance of the Fluorine in drugs and now this tiny atom has become indispensable in the drug discovery field. Fluorine gives superb properties to Drug molecules (2/2)
The presence of Fluorine is evenly distributed in all modern drugs and agrochemicals. Early applications and household usage of Fluorochemicals were as refrigerant gases. #GujaratFluorochem & #NavinFluorine were early players (3/3)
#NavinFluorine continued this legacy and has become a dominant player in Fluorochemicals, F-APIs and F-KSM. They recently bought Manchester Organics in the UK, offering F-based solutions to API industry (4/4)
Another dominant player is #SRF, which has a presence in segments like refrigerants, Pharma, and Industrial chemicals. SRF is rightly positioned to tap the potential of F-KSM & commodities (5/5)
A small Birla group company #Tanfac is engaged in producing Aluminium Fluoride (which have application in Aluminium smelters) and other basic fluorochemicals.
#AluFluoride is engaged in making Aluminium fluoride by recycling waste hydrogen fluoride gas (6/6)
Fluorine Chemistry is very challenging because of its highly corrosive nature hence requires special manufacturing set up. This and talent pool is the entry barrier for new players. Hence above a handful of players will find it easier in capturing the F-API market. (7/7)
FDA approvals in recent past show F-dominance. After a couple of years when these drugs start getting off-patent, there will be a real boom in F-API & F-KSM.

Right now, #NavinFluorine is the only player who has F-API expertise in India (8/8)
Bye the way, coined these new terms 'F-API' & 'F-KSM' while writing this thread. Hope it becomes routine (9/9)
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