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ScienceVet Profile picture
@ScienceVet2
Jul 13, 2020 • 6 tweets • 2 min read • Read on X
Need another reason to wear a mask, socially distance, and stay safe?

SARS-CoV-2 gets into cells mostly via the ACE2 receptor. Know what tissue has a lot of ACE2 receptor (besides lungs, gut, heart, etc)?

TESTICLES.
Especially a worry for those young people who "aren't affected as badly" by COVID-19, because you might not be breathing hard, but your dangly bits might be getting permanently toasted.

Don't want your spermatogenesis and steroidogenesis screwed with? Stay home and mask up.
"The main host receptor of the SARS-CoV-2 is angiotensin converting enzyme 2 (ACE2), a major component of the renin-angiotensin-aldosterone system (RAAS). The ACE2 is also involved in testicular male regulation of steroidogenesis and spermatogenesis." ncbi.nlm.nih.gov/pmc/articles/P…
"High level of expression in testis, cardiovascular and gastrointestinal system indicated that SARS-CoV-2 might not only attack the lungs... may severely damage male sexual development for younger males and lead to infertility in an adult male..." ncbi.nlm.nih.gov/pmc/articles/P…
"Testes from COVID-19 patients exhibited significant seminiferous tubular injury, reduced Leydig cells, and mild lymphocytic inflammation." ncbi.nlm.nih.gov/pmc/articles/P…
"... This might indicate that young male patients are at higher risk of testicular damage by COVID-19 than older patients." ncbi.nlm.nih.gov/pmc/articles/P…

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More from @ScienceVet2

ScienceVet Profile picture
Jul 20, 2020
"More people die of the flu every year, you're just fear mongering"

No, more than 140k Americans do NOT die from flu a year. No matter how you calculate them.

2017-18 was the worst recent year and the CALCULATED deaths are still only around 61k tops.
(61k is less than 140k in case you were wondering).

And those are the CALCULATED deaths for a YEAR. That's the number that we come to using the numbers of confirmed deaths, the number of total deaths, and a bunch of math after the season is over.
We figure out how many of those total deaths were almost definitely actually flu. For comparison, the CONFIRMED deaths for flu in an average year is 2-3k. Yes, 2-3 thousand. Again, far less than the 143,000 confirmed COVID-19 deaths in the U.S. in six months.
Read 13 tweets
ScienceVet Profile picture
Jul 14, 2020
So yesterday I talked about testicles and COVID-19. Opinions on ovaries are a little more mixed but...

TLDR: Ovaries probably have enough of the same receptors that if testicles are affected, so can ovaries be. So, if you have any interest in protecting your organs, wear a mask
ACE2 is expressed pretty widely through uterus/ovaries/placenta. ACE2 is the primary access point for the SARS-CoV-2 virus

pubmed.ncbi.nlm.nih.gov/32365180/
ACE2 isn't largely co-expressed with TMPRSS2 in reproductive tissues, which should make them less vulnerable. But this holds true for testicles too, and that doesn't protect them. No reason to think it would protect ovaries or uteri.

pubmed.ncbi.nlm.nih.gov/32622411/
Read 6 tweets
ScienceVet Profile picture
Jul 11, 2020
The "readability survey" on @ravelry is inaccessible as hell, and fails to address many of the primary concerns with the layout.

It's also incredibly ineffectively written if you actually want usable, useful data out. @outcassed and @ravelry , hire an accessibility consultant!
Seriously, 35 pages and nothing on the flickering drop shadows besides a ticky box asking if you use the setting?
"Which do you prefer?"

I prefer not having to lie down after 5 minutes of using @ravelry, or after spending 5 minutes flicking between survey options.
Read 5 tweets
ScienceVet Profile picture
Jul 10, 2020
61,067 new cases of COVID-19 yesterday in the US

State: New Infections (% of new) - (% of tot US Pop)
TX: 11,394 (19%) - (9% of US Pop)
FL: 8,935 (15%) - (6% of US Pop)
CA: 7,248 (12%) - (12% of US Pop)
AZ: 4,057 (7%) - (2% of US Pop)
GA: 2,837 (5%) - (1% of US Pop)
TX Image
FL Image
Read 5 tweets
ScienceVet Profile picture
Jul 10, 2020
So let's say you have pneumonia. It's not looking so hot.

Then you get terminal cancer. You've got a week to live.

Suddenly someone comes in and stabs you in the chest with a knife.

What do you want marked as the cause of death?

That's right: Bleeding from knife wound
Lucky for you, this is how it works! (mostly)

If you're dyING of something, but something else comes in, takes advantage of that, and kills you (you can't fight back against knife guy because of cancer and pneumonia) it's still the knife that killed you.
My dad has heart disease and diabetes. If someone breaks into his house and kneels on his chest until he dies...

The cause of death is lack of air caused by chest compression, even if his conditions make that easier.
Read 10 tweets
ScienceVet Profile picture
Jun 18, 2020
Another vaccine trial. It will be interesting to see where this goes, and I approve of the lead's comment.

theguardian.com/world/2020/jun…
This quote is good context from the lead. "Is that protection against infection? Is it protection against illness? Is it protection against severe disease? It’s quite possible a vaccine that only protects against severe disease would be very useful.”
An ideal vaccine produces sterilizing immunity, and keeps the virus from ever replicating. But less ideal vaccines are still very useful. A vaccine that kills an extant infection, for instance. Or a vaccine that attenuates infection so symptoms are milder.
Read 4 tweets

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