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1) STUDY: two mutations in SARS-2 are correlated with higher fatality: analysis of 12K SARS-2 genomes identified mutation in ORF1ab protein (aids in RNA replication) and mutation in Spike protein (needed for cell entry) correlate with fatality in nations they've taken hold in...
2) S protein mutation is the famous D614G variant that appeared in Europe and took over and previously thought to increase infectivity (bit.ly/3fUTHcJ) The new study found that the correlation between mutations and fatality holds even in sub-regions of the US...
3) Fatality rates in eastern US (hit by European variant) are higher than western US. Still, correlation isn't causation so more studies needed. If relationship holds, would be one of number of factors, e.g. age distribution, public health measures, etc...
nature.com/articles/s1003…
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Dr. Ali Nouri
@AliNouriPhD
1)TWO CDC REPORTS: There are 10X more infections than reported. That means current ~4 Million reported cases is a huge undercount.1st study did random testing in Indiana. Random is key because 1) we undertest and 2) we bias tests toward symptomatics & their contacts...
2) but we know asymptomatics are also spreaders. Study found 44% of infected had no symptoms in past 2 wks. They estimate infection-fatality rate ~0.6% (six times more than flu.) High prevalence among minorities—likely ones working essential services...
cdc.gov/mmwr/volumes/6…
3) 2nd study looked at antibodies in individuals across 10 cities. Again, 10X as many people had antibodies than reported cases. This has consequences for re-opening. With so much virus circulating, social distancing & masks more important than ever
jamanetwork.com/journals/jamai…
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Dr. Ali Nouri
@AliNouriPhD
More evidence that low-dose exposure results in asymptomatic disease. Study follows two cohorts of Swiss soldiers. One cohort was infected prior to social distancing when there was lots of mingling. The second cohort got infected after going into social distancing...1/2
...while 30% of the first group developed symptomatic disease, none in social distancing cohort developed symptoms, even though 13 tested positive for SARS-2. Importantly, the asymptomatic cases still had antibodies..2/2

TY for flagging @MonicaGandhi9
academic.oup.com/cid/article/do…
And here's more evidence...
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Dr. Ali Nouri
@AliNouriPhD
HVAC professionals: viruses like SARS-2 stay airborne and can travel long distances in rooms & air ducts of ventilation systems. The Assoc. of European HVAC professionals proposes, esp. in ‘hot spots’ to take a set of measures that help to control the airborne route...1/3
...these include increasing fresh air supply and avoiding recirculation of air; increasing exhaust ventilation; staying away from poorly ventilated spaces, among other measures. @REHVAHVAC guidance: bit.ly/39htG4V ...2/3
...US HVAC experts statement:

Transmission of SARS-CoV-2 through the air is sufficiently likely that airborne exposure to the virus should be controlled. Changes to building operations, including the operation of HVAC systems can reduce airborne exposure

Good to see action! 3/3
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