So, let's recap why does it matter.
This is not a hypothetical thing. It's happened nine times in our history.
Of those vacancies, four succeeding VPs have gone on to be elected to their own terms. Most of the nine won their party's next nomination.
Bush, Reagan, Ford, + FDR were all nearly killed. Reagan was seriously wounded.
So, yes, while it's understandable to see why folks might think this doesn't matter, it very much does.