All of the other RCTs (SOLIDARITY, RECOVERY, etc) were in very sick patients and are borderline worthless because they just support what we've been saying since March—HCQ is for early disease, not late.
This means that a positive diagnosis was made based on only SYMPTOMS for the vast majority of participants.
This isn’t great, but it gets worse.
So the quality of the diagnosis was essentially equivalent to someone typing symptoms into WebMD.
It would diminish the observed therapeutic effect of hydroxychloroquine (HCQ probably isn’t going to help allergies or the common cold).
If the researchers had kept their original end point (hospitalization/death), the study would've actually shown a strong trend toward benefit for HCQ.
Instead, the researchers changed the end point mid-study from hospitalizations/death to symptoms at 14 days.
This did not reach significance, but would have been strong encouragement to proceed with additional higher powered RCTs.
Yet, with their vast resources, neither the WHO nor NIH conducted a trial on this.
Instead Dr. Fauci's evidence for the inefficacy of HCQ comes from an online survey under the guise of an RCT.