1)Gilead's Truvada
Used in HIV for treatment of adults & children in combination with other drugs
2019 sales $2.64bn
Off patent Sep 30,2020
2)Novartis Afinitor
immunosuppressant in transplant,renal &other cancers
2019 sales - $1bn
Generic Dec10,2019
Use Stoppage of Smoking,treat nicotine addiction,decreases craving
2019 sales $899mn
Off patent Nov 20
2)Merck Nuvaring
Birth control vaginal ring,contraceptive
2019 sales $742mn
Generic launched Dec 2019ĺ
Treatment of severe osteoporosis,builds bone
2019 sales $645mn
Biosimilar launch Dec 2020
6)Gileads Atripla
Use treatment of HIV in adults & children,alone or in combination
2019 Sales $501mn
Generic expected Sep 2020
Treat middle & outer ear infections in children & adults
2019 sales $470mn
Generic expected 2020
8)Biomarin Kuvan
Only FDA approved medication for phenylketonuria to reduce phenylalanine levels
2019 sales $463mn
Generic expected Oct 2020
Antipsychotics used in schizophrenia,bipolar & autism
2019 sales $314 mn
Patent expiry Nov25 2020
10)Tevas Proair HFA
Inhaler used in asthma & COPD to dilate the airways
2019 sales $274mn
Generic launched Feb 2020
Above are some top drugs losing patent